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An Integrated Nonclinical and Clinical Risk Assessment of the Effects of Investigational ATRi Tuvusertib on QTc Interval in Patients With Solid Tumors
Tuvusertib is an investigational, orally administered inhibitor of ATR protein kinase, currently in Phase II clinical development. Here, we present an integrated nonclinical and clinical assessment of the effect of tuvusertib on QTc interval. In vitro inhibition by tuvusertib of the hERG potassium channel was evaluated, and in vivo ECG assessments evaluated the effect on… →
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Standard chemoradiotherapy with concurrent and adjuvant camrelizumab in patients with high risk nasopharyngeal carcinoma: multicentre, randomised, open label, phase 3 trial
CONCLUSION: The addition of camrelizumab to concurrent chemoradiotherapy and as a maintenance treatment improved progression-free survival among patients with high risk nasopharyngeal carcinoma after induction chemotherapy. →
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Effect of pirfenidone on plasma markers of collagen turnover in patients with heart failure, preserved left ventricular ejection fraction and myocardial fibrosis
CONCLUSIONS: In patients with stable heart failure with preserved ejection fraction, pirfenidone treatment had no sustained effect on plasma levels of PICP and CITP at 52 weeks. Changes in ECV during treatment with pirfenidone are associated with changes in plasma PICP and CITP, suggesting a weak association between changes in collagen volume/mass and plasma markers… →
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Feasibility of the MAINTAIN intervention to support independence after a fall for people with dementia: a pilot cluster randomised controlled trial in participants’ own homes
CONCLUSIONS: The pilot c-RCT demonstrated that recruitment, retention and intervention delivery were feasible and well accepted. Findings support progression to a definitive trial to evaluate the effectiveness and cost-effectiveness of the MAINTAIN intervention. →
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How to Profit From Retro-Innovation
Kirsten Ulve/theispot.com As the phrase “brain rot” has exploded in usage over the last couple of years, evolving from a humorous jab at wasting time online into a genuine descriptor for the mental fatigue brought on by endless scrolling, many have resorted to a solution that is surprisingly retro. From 2021 to 2024, feature phone… →
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Take 5: We Can Work It Out
Conflicts crop up all the time in the workplace, regardless of the job or industry. So it’s critical for business leaders and workers at all levels to know how to respond when conflicts occur, either within or between organizations. Below, faculty at the Kellogg School offer strategies for handling different types of work conflict, based… →
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Therapeutic Impact of Systemic Probiotics Combined with Mechanical Debridement in Peri-Implant Disease: A Clinical and Microbiological Evaluation
CONCLUSION: Systemic probiotics, when used as an adjunct to mechanical debridement, significantly improve clinical and microbiological outcomes in peri-implantitis management. This combination may offer a synergistic approach for enhanced therapeutic efficacy. →
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Incidence, Risk Factors, and Outcomes in Stressor-Associated Atrial Fibrillation: Insights From the VITAL-AF Trial
CONCLUSIONS: Among >30 000 primary care patients with adjudicated AF events, nearly one-third of incident AF cases were stressor associated. Despite similar risk factor profiles and comparably high rates of adverse outcomes, oral anticoagulant initiation is lower when AF is stressor associated. Future work is needed to define optimal approaches to prevention, surveillance, and management… →
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What the UN Treaty on Cybercrime May Mean for You
Carolyn Geason-Beissel/MIT SMR | Getty Images In crimes such as robberies or kidnappings, both the criminals and victims must directly interact in person, so it is obvious that they must both be in the same country for the crime to be committed. Local and/or federal authorities address such crimes. But cybercrimes involving data theft and… →
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Podcast: How Do Those Valentine’s Day Roses End Up in Your Bouquet? It’s Complicated.
Valentine’s Day is a day of love. But for those who sell roses, it’s probably a day full of something else. “Probably a lot of stress, right? This is the chance to make money for everybody that’s concerned, right? This is the opportunity where you can clean up for the year,” says Martin Lariviere, a… →