CONCLUSION: Severity-graded exercise rehabilitation effectively improves diaphragmatic function and enhances endogenous antioxidant capacity in hospitalized AECOPD patients. The improvement in diaphragmatic excursion was significantly correlated with favorable changes in oxidative stress biomarkers, suggesting a potential physiological association. These findings support the efficacy of severity-graded rehabilitation but warrant further mechanistic studies. →

CONCLUSIONS: The topical formulation appeared to be an effective and well-tolerated emollient; however, the absence of a vehicle control precludes attribution of effects specifically to the active ingredients. Patient-reported outcomes should be interpreted with caution due to the unblinded design. →

Stress and anxiety are prevalent mental health conditions that often coexist with cardiovascular comorbidities, resulting in a complex interplay between psychological and physiological processes, partly mediated through activation of the hypothalamic-pituitary-adrenal (HPA) axis. Ashwagen®, a standardized extract of Withania somnifera (Ashwagandha), has demonstrated adaptogenic and anxiolytic properties in preclinical and clinical studies. This study aimed… →

CONCLUSIONS: Mirikizumab induction and maintenance is efficacious in moderately-to-severely active ulcerative colitis with or without prior failure of advanced therapy, including difficult-to-treat disease. →

CONCLUSIONS: Negative pressure wound therapy is not clinically or cost-effective in augmenting healing in patients with surgical wounds healing by secondary intention, particularly those with comorbidities. →

Objective: To evaluate the efficacy and safety of low-dose compound tropicamide eye drops for pupillary dilation in premature infants undergoing the fundus examination. Methods: A non-inferiority, randomized, controlled, crossover trial was conducted. Preterm infants hospitalized in the Department of Neonatology, the First Affiliated Hospital of Zhengzhou University scheduled for retinopathy of prematurity screening between October… →

CONCLUSIONS: E-Fit is a feasible intervention suggesting EF and social responsiveness improvements in children with cCHD. Motivational strategies to improve adherence to computerised training should be refined before a full-scale efficacy trial. →

CONCLUSIONS: The majority of individuals identified by the instrument also met the diagnostic criteria for an anxiety disorder. Generalised anxiety disorder and panic disorder were the most prevalent subtypes. Anxiety was common across the cardiac population, underscoring the need for routine assessment and targeted intervention in clinical practice. →

CONCLUSIONS AND RELEVANCE: IOT+GOT was more cost-effective than GOT alone over 2 yr, supporting its wider adoption as an economically sound rehabilitation strategy for clients with schizophrenia. Given the extent of missing cost data, the results should be interpreted with appropriate caution. These findings offer long-term economic evidence to inform mental health policies and resource… →