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  • Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review

    27 апреля, 2024

    Antonio D’Amato April 27, 2024 Medicina (Kaunas). 2024 Apr 6;60(4):608. doi: 10.3390/medicina60040608. ABSTRACT Background and Objectives: Despite advancements in detection and treatment, cervical cancer remains a significant health concern, particularly among young women of reproductive age. Limited data exists in the literature regarding fertility-sparing treatment (FST) of cervical cancers with tumor sizes greater than 2… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • GNB1 Encephalopathy: Clinical Case Report and Literature Review

    27 апреля, 2024

    Matas Nasvytis April 27, 2024 Medicina (Kaunas). 2024 Apr 1;60(4):589. doi: 10.3390/medicina60040589. ABSTRACT GNB1 encephalopathy is a rare genetic disease caused by pathogenic variants in the G Protein Subunit Beta 1 (GNB1) gene, with only around 68 cases documented worldwide. Although most cases had been caused by de novo germline mutations, in this case, the… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • Transitioning to a Personalized Approach in Molecularly Subtyped Small-Cell Lung Cancer (SCLC)

    27 апреля, 2024

    Anna Grenda April 27, 2024 Int J Mol Sci. 2024 Apr 10;25(8):4208. doi: 10.3390/ijms25084208. ABSTRACT Lung cancer has become a major public health concern, standing as the leading cause of cancer-related deaths worldwide. Among its subtypes, small-cell lung cancer (SCLC) is characterized by aggressive and rapid growth, poor differentiation, and neuroendocrine features. Typically, SCLC is… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • Potential Benefits of Photon-Counting CT in Dental Imaging: A Narrative Review

    27 апреля, 2024

    Chiara Zanon April 27, 2024 J Clin Med. 2024 Apr 22;13(8):2436. doi: 10.3390/jcm13082436. ABSTRACT Background/Objectives: Advancements in oral imaging technology are continually shaping the landscape of dental diagnosis and treatment planning. Among these, photon-counting computed tomography (PCCT), introduced in 2021, has emerged as a promising, high-quality oral technology. Dental imaging typically requires a resolution beyond… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • Fluorescence-Guided Laparoscopy after Oral Hypericin Administration for Staging of Locally Advanced Gastric Cancer-A Pilot Study

    27 апреля, 2024

    Can Yurttas April 27, 2024 J Clin Med. 2024 Apr 21;13(8):2422. doi: 10.3390/jcm13082422. ABSTRACT (1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This prospective, single-arm, open-label clinical trial aimed to assess… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • Exploring the Link between Anticoagulation, Cognitive Impairment and Dementia in Atrial Fibrillation: A Systematic Review

    27 апреля, 2024

    Abhimanyu Agarwal April 27, 2024 J Clin Med. 2024 Apr 21;13(8):2418. doi: 10.3390/jcm13082418. ABSTRACT Background: The impact of oral anticoagulants (OACs) on cognitive impairment and dementia in patients with atrial fibrillation (AF) is not well characterized. This systematic review aims to address this knowledge gap. Methods: SCOPUS and PubMed searches were conducted to identify articles… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • Neutrophil Extracellular Traps and Respiratory Disease

    27 апреля, 2024

    Paul T King April 27, 2024 J Clin Med. 2024 Apr 19;13(8):2390. doi: 10.3390/jcm13082390. ABSTRACT Extracellular traps made by neutrophils (NETs) and other leukocytes such as macrophages and eosinophils have a key role in the initial immune response to infection but are highly inflammatory and may contribute to tissue damage. They are particularly relevant to… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • Sonography as a Diagnostic Tool in Midurethral Sling Complications: A Narrative Review

    27 апреля, 2024

    Aneta Zwierzchowska April 27, 2024 J Clin Med. 2024 Apr 18;13(8):2336. doi: 10.3390/jcm13082336. ABSTRACT Despite the established safety and efficacy of midurethral slings (MUS), which are the current gold standard treatment for stress urinary incontinence (SUI), the potential for postoperative complications remains a significant concern for both healthcare professionals and patients. Meanwhile, sonography has emerged… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • Insights on the Choice and Preparation of the Donor Nerve in Corneal Neurotization for Neurotrophic Keratopathy: A Narrative Review

    27 апреля, 2024

    Pietro Luciano Serra April 27, 2024 J Clin Med. 2024 Apr 14;13(8):2268. doi: 10.3390/jcm13082268. ABSTRACT The article introduces neurotrophic keratopathy (NK), a condition resulting from corneal denervation due to various causes of trigeminal nerve dysfunctions. Surgical techniques for corneal neurotization (CN) have evolved, aiming to restore corneal sensitivity. Initially proposed in 1972, modern approaches offer… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
  • The Natural History of Retinal Sensitivity Loss in Diabetic Macular Ischemia over One Year Evaluated by Microperimetry

    27 апреля, 2024

    Wei-Shan Tsai April 27, 2024 J Clin Med. 2024 Apr 11;13(8):2219. doi: 10.3390/jcm13082219. ABSTRACT Background/Objectives: This one-year prospective observational study, conducted at two centers, aimed to report the natural history of retinal sensitivity (RS) loss in diabetic macular ischemia (DMI). Methods: Patients with stable-treated proliferative diabetic retinopathy (PDR) were recruited if there was evidence of… →

    Clinical Trials
    Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
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