Henning Zelba April 27, 2024 Vaccines (Basel). 2024 Apr 9;12(4):397. doi: 10.3390/vaccines12040397. ABSTRACT Ovarian cancer is one of the most common cancers among women and the most lethal malignancy of all gynecological cancers. Surgery is promising in the early stages; however, most patients are first diagnosed in the advanced stages, where treatment options are limited.… →
Ricardo Corona-Torres April 27, 2024 Vaccines (Basel). 2024 Apr 9;12(4):395. doi: 10.3390/vaccines12040395. ABSTRACT Campylobacter is a major cause of acute gastroenteritis in humans, and infections can be followed by inflammatory neuropathies and other sequelae. Handling or consumption of poultry meat is the primary risk factor for human campylobacteriosis, and C. jejuni remains highly prevalent in… →
Angelo Michele Inchingolo April 27, 2024 Pharmaceuticals (Basel). 2024 Apr 22;17(4):542. doi: 10.3390/ph17040542. ABSTRACT The goal of this review is to shed light on the management of orofacial discomfort after a cancer diagnosis in the head and neck region. A search was conducted on PubMed, Scopus, and Web of Science to identify studies on postoperative… →
Ralph Brattsand April 27, 2024 Pharmaceuticals (Basel). 2024 Apr 15;17(4):503. doi: 10.3390/ph17040503. ABSTRACT The introduction of inhaled corticosteroids (ICSs) changed over a few decades the treatment focus of mild-to-moderate asthma from bronchodilation to reduction in inflammation. This was achieved by inhaling a suitable corticosteroid (CS), giving a high, protracted airway concentration at a low total… →
Tiffany W Chow April 27, 2024 Pharmaceuticals (Basel). 2024 Mar 22;17(4):408. doi: 10.3390/ph17040408. ABSTRACT Brain somatic gene recombination (SGR) and the endogenous reverse transcriptases (RTs) that produce it have been implicated in the etiology of Alzheimer’s disease (AD), suggesting RT inhibitors as novel prophylactics or therapeutics. This retrospective, proof-of-concept study evaluated the incidence of AD… →
Diana Trujillo-Benítez April 27, 2024 Pharmaceutics. 2024 Apr 12;16(4):532. doi: 10.3390/pharmaceutics16040532. ABSTRACT Recently, we reported a new fibroblast activation protein (FAP) inhibitor radiopharmaceutical based on the 99mTc-((R)-1-((6-hydrazinylnicotinoyl)-D-alanyl) pyrrolidin-2-yl) boronic acid (99mTc-HYNIC-D-Alanine-BoroPro)(99mTc-HYNIC-iFAP) structure for tumor microenvironment SPECT imaging. This research aimed to synthesize 68Ga-[2,2′,2″,2‴-(2-(4-(2-(5-(((S)-1-((S)-2-boronopyrrolidin-1-yl)-1-oxopropan-2-yl)carbamoyl)pyridin-2-yl)hydrazine-1-carbothioamido)benzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid] (68Ga-DOTA-D-Alanine-BoroPro)(68Ga-iFAP) as a novel radiotracer for PET imaging and evaluate its… →
Yasuhiko Komatsu April 27, 2024 Nutrients. 2024 Apr 20;16(8):1230. doi: 10.3390/nu16081230. ABSTRACT A randomized, placebo-controlled, double-blind, parallel-group clinical study was conducted to examine the effects of ingesting a heat-killed lactic acid bacterium, Lactobacillus johnsonii No. 1088 (LJ88) on temporal gastroesophageal reflux-related symptoms in healthy volunteers. A total of 120 healthy Japanese volunteers of both sexes,… →
Ilona Korzonek-Szlacheta April 27, 2024 Nutrients. 2024 Apr 20;16(8):1227. doi: 10.3390/nu16081227. ABSTRACT The burden of cardiovascular disease and the percentage of frail patients in the aging population will increase. This study aims to assess the circulating levels of several cytokines in frail patients. This is an ancillary analysis of the FRAPICA trial. The ratio of… →
Yun-Ah Lee April 27, 2024 Nutrients. 2024 Apr 13;16(8):1155. doi: 10.3390/nu16081155. ABSTRACT An increased homocysteine level is a risk factor for cardiovascular disease, venous thromboembolism, cerebrovascular disease, and chronic kidney disease. In addition, vitamin D deficiency is associated with coronary artery disease and metabolic disorders. The present study included data from 1375 adults (895 men… →
Domingos Roda April 27, 2024 Genes (Basel). 2024 Apr 17;15(4):501. doi: 10.3390/genes15040501. ABSTRACT Glioblastoma, the most aggressive and common malignant primary brain tumour, is characterized by infiltrative growth, abundant vascularization, and aggressive clinical evolution. Patients with glioblastoma often face poor prognoses, with a median survival of approximately 15 months. Technological progress and the subsequent improvement… →