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Automated Oxygen Delivery in Home Setting for Patients with COPD on Long-Term Oxygen Therapy — A Randomized Crossover Feasibility Trial
CONCLUSION: Automated oxygen titration is feasible in the home setting, achieving more time with normoxia, but it required a wide flow range and continuous SpO2 monitoring. The patients reported a clinically relevant reductions in COPD symptoms measured with CCQ. The clinical importance of controlling SpO(2) needs to be examined in a larger study. →
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Comparative analysis of postoperative results of various methods of treatment of inguinal hernias
To assess and compare the long-term postoperative complications, postoperative pain incidences, and hernia recurrence rates following surgery for inguinal hernias using different surgical approaches, namely transabdominal preperitoneal (TAPP), TAPP with the internal ring suturing (TAPP-IRS), Liechtenstein technique, and Shouldice technique. This study is a multicentre clinical trial that involves 302 patients ranging from 18 to… →
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Effectiveness of transcranial direct current stimulation on emotional instability and impulsivity in atypical depression and bipolar II disorder
Atypical depressive disorder and bipolar disorder often present with symptoms like emotional instability and impulsive behaviors. Various treatments, both pharmaceutical and non-pharmacological, are employed to manage these conditions. Transcranial direct current stimulation (tDCS) is a modern treatment option that has shown promise with minimal side effects. This study aims to compare the effectiveness of tDCS… →
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Comparison of Oral Desensitization with Heated Cow’s Milk Products with Conventional Desensitization Method in Children with Cow’s Milk Allergy
Cow’s milk allergy (CMA) is one of the most prevalent Immunoglobulin E (IgE)-dependent food allergies in children. Currently, the only accepted treatment for food allergy is avoiding the relevant allergen. The purpose of this study is to investigate the immunological changes following the consumption of heated cow’s milk products compared to the usual method of… →
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How Grocery Retail Innovations Change Customer Behavior
Nick Lowndes/Ikon Images Grocery retailers are racing to reinvent the customer experience. As omnichannel shopping becomes the norm — with 90% of consumers now purchasing food through both online and offline channels — grocers are deploying new tactics to attract shoppers, build loyalty, and drive profitability. But do these customer experience investments actually pay off?… →
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Scaling GenAI: Get Big Value From Smaller Efforts
Related Reading M. Webster and G. Westerman, «Generate Value From GenAI With ‘Small t’ Transformations,» MIT Sloan Management Review, Jan. 22, 2025. Despite two years of broad experimentation, most companies aren’t seeing the large-scale GenAI transformations they initially envisioned. The challenge isn’t the technology’s potential — it’s understanding how to generate real value at three… →
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The Economic Price We Pay for War
The consequences of war are devastating. While it’s often the most-visually striking results that grab our attention, in examining the costs of war, it is crucial to understand how it affects the economy. “Of course, economic consequences do not encompass all of the misery that war inflicts on people,” says Efraim Benmelech, a Kellogg professor… →
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Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study
Endurance exercise may be associated with acute damage to intestinal epithelial cells. The effect of caffeine supplementation, and whether this is influenced by common genetic polymorphisms (ADORA2A: rs5751876 and CYP1A2: rs762551), is not currently known. Participants (n = 18 men and women) ingested caffeine (3 mg/kg body mass) or placebo 45 min before cycling (20… →
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TRPM8 Agonist (Cryosim-1) Cream for Chronic Prurigo: A Randomized, Vehicle-controlled Trial
Chronic prurigo (CP) is a distressing dermatological condition lacking effective topical therapies. This randomized, double-blind, vehicle-controlled trial evaluated the efficacy and safety of Cryosim-1, a TRPM8 agonist cream, in 30 adults with CP. Participants were assigned to apply Cryosim-1 0.1%, 0.5%, or vehicle cream 3 times daily for 4 weeks. Both active formulations significantly reduced… →
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Effects of psycho-cardiology care on psychological and clinical outcomes among primary aldosteronism patients undergoing adrenal vein sampling: A randomized controlled study
Adrenal vein sampling (AVS) is considered the gold standard for the subtyping diagnosis of primary aldosteronism (PA), which is essential for preventing adverse cardiovascular outcomes. Nevertheless, the AVS procedure might induce anxiety in patients with PA because of discomfort and the uncertainty of the outcome. Therefore, this study aimed to assess the effectiveness of psycho-cardiology… →
