CONCLUSIONS: The combination of sintilimab and chemotherapy as a neoadjuvant regimen was tolerable and associated with favorable responses for ESCC patients. Given these favorable results, this regimen could serve as a viable alternative in the neoadjuvant treatment landscape for ESCC, with particular applicability to Chinese patient populations. →

CONCLUSION: This study showed little effect of winter electricity vouchers on exacerbations of COPD. However, such vouchers increased energy use and may have reduced overall mortality. A larger study, particularly with susceptible subpopulations, is recommended to examine this mortality impact further. →

CONCLUSIONS: Dexmedetomidine enhances postoperative sleep quality in older patients undergoing intestinal surgery by reducing cortisol levels, increasing melatonin production and effectively alleviating pain, thereby supporting better recovery outcomes. →

CONCLUSIONS: This cohort study showed that a higher Aβ42 ratio was associated with an increased delirium risk and severity, and the association was linear. The plasma Aβ42 ratio might be a mini-invasive biomarker to identify postoperative delirium. →

CONCLUSIONS: QLAsomes showed up to 32% higher expression inhibition of key skin sensitization-related factors than individual components, and based on this, improved pruritus by 67% more than placebo. As nanovesicles with skin-soothing properties, they are effective for drug encapsulation and managing skin sensitivity in pharmaceutical and cosmetic industries. →

Physical inactivity depresses glycemic control, an impairment that can be prevented with exercise. We investigated whether electrical muscle stimulation (EMS) with blood flow restriction (BFR) could similarly prevent the impairments in glycemic control associated with physical inactivity and whether this was effective for attenuating the loss of physical function after inactivity. Thirty-two participants underwent 1… →

CONCLUSIONS: Sixteen weeks of HIIT and vitamin D consumption showed greater benefits for BMD levels in women with osteoporosis than either vitamin D consumption or HIIT training alone. Therefore, HIIT plus vitamin D consumption may be a strategic option to prevent BMD reduction with aging or to slow demineralization. →

CONCLUSION: In conclusion, the current study revealed that regular walking exercise of light to moderate intensity significantly contributes to improvements in pain, walking speed, balance, lower extremity dynamic balance, and activities of daily living in postmenopausal women with osteopenia compared to inactive individuals. →