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Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes trial (TC4): a Bayesian pragmatic cluster randomized controlled trial
BACKGROUND: Dual antiplatelet therapy is the standard of care for acute coronary syndrome, but uncertainty exists regarding the optimal regimen for patients in North America. We sought to compare the effectiveness and safety of acetylsalicylic acid (ASA) and ticagrelor or clopidogrel in patients with acute coronary syndrome from a single tertiary academic centre in Montréal,… →
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User Stickiness – Липкость пользователей. Когда пользователи возвращаются к продукту снова и снова, значит, продукт действительн…
User Stickiness – Липкость пользователей. Когда пользователи возвращаются к продукту снова и снова, значит, продукт действительно нужен. Как улучшить «липкость» и сделать продукт более привлекательным для долгосрочного использования. #Менеджмент #Продукт #ИИ #Продуктовыймененджмент #ИИМенеджмент →
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Meet ReSearch: A Novel AI Framework that Trains LLMs to Reason with Search via Reinforcement Learning without Using Any Supervis…
Meet ReSearch: A Novel AI Framework that Trains LLMs to Reason with Search via Reinforcement Learning without Using Any Supervised Data on Reasoning Steps Large language models (LLMs) have demonstrated significant progress across various tasks, particularly in reasoning capabilities. However, effectively integrating reasoning processes with external search operations remains challenging, especially for multi-hop questions requiring… →
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Videoconference-Delivered Acceptance and Commitment Therapy for Family Caregivers of People With Dementia: Pilot Randomized Controlled Trial
CONCLUSIONS: The videoconference-delivered ACT program showed promise in improving mental health outcomes and ACT processes among family caregivers with depression who give care to individuals with dementia. Future studies should aim to replicate these findings with larger, more diverse caregiver populations and explore the long-term efficacy of videoconference-delivered ACT programs. →
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Evaluating reliable and clinically significant changes in health outcomes of a mindfulness-based cognitive defusion training program among older adults with mild cognitive impairment: a randomized controlled trial
CONCLUSIONS: The M-bCCDT program positively impacted perceived stress and mindfulness awareness in older adults with MCI, facilitating the improvements in memory and psychomotor speed, with these benefits sustained for 20 weeks. It offers a systematic approach for community healthcare providers in MCI stress management. →
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Effectiveness of Massage Gun Versus Myofascial Release Technique for Releasing Latent Trigger Points of the Calf Muscle: A Protocol for Randomized Clinical Trial
BACKGROUND AND PURPOSE: Trigger points can disrupt muscle activity patterns and cause cramping, fatigue, and weakening. Massage guns and myofascial release are widely employed for such circumstances, but their isolated outcomes are unknown. This study aimed to compare the effectiveness of a massage gun versus myofascial release technique on subjective pain, pain pressure threshold and… →
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Group Interpersonal Psychotherapy for Adolescents With Non-suicidal Self-injury: A Randomized Controlled Study
Non-suicidal self-injury (NSSI) is a significant clinical concern in adolescents. The goal of this study was to evaluate the efficacy of group interpersonal psychotherapy (G-IPT) combined with treatment as usual (TAU) compared with TAU alone in treating adolescents with NSSI. A randomized controlled trial was conducted in a psychiatric outpatient clinic in Hubei Province, China,… →
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A group psychological intervention for postnatal depression in British mothers of South Asian origin — the ROSHNI-2 RCT
CONCLUSIONS: The results of this study provide robust evidence that the culturally adapted psychological intervention for postnatal depression in South Asian women is effective at the primary end point and acceptable to women. →
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Implementation of Site-Specific Hepatitis C Virus Treatment Workflows for Vulnerable, High-Risk Populations: A Prospective Single-Arm Trial
CONCLUSIONS: We identified gaps along the HCV care cascade between: (1) enrolled to prescribed treatment and (2) completed treatment to assessed for cure. Site-specific HCV treatment workflows were insufficient to engage participants in care and avoid treatment delays. Novel approaches are needed and these may include patient outreach, patient navigation, test-and-treat protocols, and removing financial… →
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Electrocardiometry for the Management of Pediatric Septic Shock: A Pilot Randomized Controlled Trial
CONCLUSIONS: Advanced hemodynamic monitoring with electrocardiometry along with clinical assessment led to a restrictive fluid strategy in addition to minimizing the risk of fluid overload. →
