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Microbiological Analysis of Lower Airway Samples: Does It Influence the Outcome in Patients With Community-Acquired Pneumonia?
This prospective randomized trial examined the impact of extensive lower respiratory tract sampling and microbial analysis on treatment decisions and patient outcomes in community-acquired pneumonia (CAP). One hundred and eighteen patients were randomized to rigorous sampling (intervention group, n = 64) or standard care (control group, n = 54). The primary outcome was antibiotic therapy… →
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components
CONCLUSIONS: With the population THRIVE involved, at a stage of pregnancy when a lot of support is offered (with many parenting interventions being offered without rigorous evaluation), we do not have evidence to recommend the rollout of Enhanced Triple P for Baby or Mellow Bumps. →
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Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial
CONCLUSIONS: As well as being more cost-effective, quetiapine may be a more clinically effective augmentation option for treatment-resistant depression. →
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Upadacitinib as monotherapy in patients with rheumatoid arthritis and prior inadequate response to methotrexate: results at 260 weeks from the SELECT-MONOTHERAPY randomised study
CONCLUSION: No new safety risks were identified with long-term UPA treatment. UPA monotherapy was efficacious in treating rheumatoid arthritis through week 260. →
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Tightly Coupled Range Inertial Odometry and Mapping with Exact Point Cloud Downsampling
This paper introduces a SLAM framework that achieves real-time CPU-only performance in dense, registration-error-minimization-based odometry and mapping by leveraging exact point cloud downsampling via coreset extraction, eliminating the need for GPU acceleration. Key Highlights Exact Point Cloud Downsampling via Coresets – Selects a minimal subset of residuals that exactly preserve the quadratic registration error function for a given pose,… →
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NVIDIA AI Introduces Audio-SDS: A Unified Diffusion-Based Framework for Prompt-Guided Audio Synthesis and Source Separation without Specialized Datasets
Audio diffusion models have achieved high-quality speech, music, and Foley sound synthesis, yet they predominantly excel at sample generation rather than parameter optimization. Tasks like physically informed impact sound generation or prompt-driven source separation require models that can adjust explicit, interpretable parameters under structural constraints. Score Distillation Sampling (SDS)—which has powered text-to-3D and image editing… →
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Reliability and usability of a portable spirometer compared to a laboratory spirometer
CONCLUSIONS: The portable spirometer exhibited a strong correlation and agreement with a high-quality laboratory spirometer, as well as concordance in spirometric abnormality diagnosis and severity classification. Non-specialist can obtain acceptable results using this portable spirometer. →
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The Reliability of a Novel Structured Testing Device for Single-breath Lung Carbon Monoxide Uptake: A Randomized Comparison Crossover Study
CONCLUSION: The MeHow MeAir 9000 spirometer provides high accuracy measurements of lung diffusing capacity and reliable assessment of the severity of diffusing capacity impairment, making it suitable for clinical use. →
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Long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis: an interim analysis of the phase 3 U-ACTIVATE long-term extension study
BACKGROUND: The U-ACTIVATE long-term extension study aims to evaluate the long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis. Here, we report interim results after 3 years of total treatment. →
