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Development of an intervention theory for a mobile mammography unit research project for breast cancer screening
SETTING: In France, participation rates in breast cancer screening have been decreasing, along with socio-territorial inequalities. To enhance women’s access to breast cancer screening, an interventional research project was implemented to assess the effectiveness, efficiency, and optimal modalities of a mobile mammography unit for women living remotely in Normandy. →
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In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug-Metabolizing Enzymes
Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan-genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time-dependent inhibitor of CYP3A4. These results prompted further evaluation in… →
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A Phase 1, Open-Label, Single Ascending (Two Levels) Dose Study to Evaluate the Pharmacokinetics of Vorasidenib in Healthy Japanese and Non-Asian Participants
Vorasidenib was first approved in 2024 for the treatment of Grade 2 gliomas with isocitrate dehydrogenase 1 and 2 mutations and is now approved in over 40 countries, including Japan. During early development, vorasidenib pharmacokinetics (PK) was estimated in populations without Japanese participants. In 2019, this Phase 1 single ascending (two levels) dose study (NCT04145128)… →
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Dermatologic outcomes associated with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a large-scale target trial emulation
CONCLUSION: In a large, real-world study designed to emulate a clinical trial, GLP-1 RAs were linked to increased psoriasis and decreased autoimmune blistering diseases compared with DPP-4is over up to 4 years’ follow-up. These results provide a dermatologic safety context to guide incretin therapy selection and highlight the importance of ongoing skin monitoring. →
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Diagnostic Accuracy for Breathing Sounds in Using an AI-Assisted Stethoscope Versus a Conventional Stethoscope
Purpose: This study compares the accuracy of dental students in diagnosing different breathing sounds using traditional versus artificial intelligence-assisted precordial stethoscopes (AIPS). Methods: The study involved 45 3rd- and 4th-year dental students who completed a pre-test to assess their baseline knowledge of breathing sounds. After watching a learning video, participants were randomized into 3 groups:… →
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Safety and Efficacy of SOX Therapy After Preoperative Chemoradiotherapy for Advanced Lower Rectal Cancer: A Phase I Study
CONCLUSION: SOX therapy as consolidation chemotherapy after CRT was safe and well tolerated as part of the TNT for lower rectal cancer. To our knowledge, this is the first study to report the use of SOX in TNT. Further trials are warranted to evaluate the efficacy of SOX as consolidation therapy after CRT in larger… →
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The real risk of AI is not job loss — it is a failure of imagination
The most important economic question in the AI era is not how many jobs will be replaced. It is whether AI is expanding human capacity: what we can imagine, do, and want. Youngjin Yoo argues that the demand frontier of human capacity — the outer limit of what people want, attempt, and are willing to… →
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What Global Turmoil Means for Company Structure
Chris Gash/theispot.com The international order is undergoing structural transformation. War in the Middle East, the prolonged conflict in Ukraine, and major shifts in U.S. trade and foreign policy that have altered the country’s traditional alliances are manifestations of a broader reconfiguration of power. Tariffs, export controls, sanctions, and the vulnerability of strategic choke points as… →
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Pain sensitivity following a standardized two-hour cycling session: a randomized controlled crossover Study
CONCLUSION: Findings suggest that long duration exercise of a standardized moderate intensity may not be effective to induce EIH in trained male cyclists, while also no hyperalgesia is observed. These results are not different between loaded and unloaded body parts. →
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Exploring Participant Perspectives on Implementation and Sustainment of Taking It to the Pews: A Faith-Based HIV Intervention With African American Churches
African American faith institutions can play a key role in increasing HIV education and testing in communities disproportionately burdened by HIV. This focus group study explored church participant perspectives of a religiously tailored HIV education and testing intervention implemented through a clustered, randomized controlled trial with 14 African American churches in Kansas City. Focus group… →