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Evaluation of the Efficacy and Safety of a 3D Navigation-Guided Transcatheter Aortic Valve Implantation Technique in Patients With Severe Aortic Stenosis and a High Risk of Atrioventricular Conduction Disorders: Results of a Pilot Randomized Study
Aim To evaluate the efficacy and safety of a new 3D navigation-guided technique for transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS) and a high risk of atrioventricular (AV) conduction disorder.Material and methods The study presents the results of a single-center prospective randomized pilot study. Sixty patients meeting inclusion and exclusion… →
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Behavioral and electrophysiological evidence of reward processing deficits in repetitive negative thinking: Implications for depression
CONCLUSIONS: RNT may transiently disrupt behavioral and neural indicators of reward functioning. These findings suggest that cognitive states such as RNT can exacerbate or reveal the latent reward-processing deficits typically observed in individuals with anhedonia. This state-dependent sensitivity highlights the potential utility of targeting RNT to restore reward processing in depression. →
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The Effects of a Health Literacy Promotion Program on Health Behaviors and Blood Pressure Levels Among Uncontrolled Hypertensive Patients: A Quasi-Experimental Study
CONCLUSIONS: The health literacy promotion program significantly improved health behaviors and reduced systolic blood pressure, suggesting its feasibility for implementation in primary care settings. Future research should employ larger sample sizes and extended follow-up periods to thoroughly examine the program’s long-term effectiveness across diverse populations. →
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White light imaging versus artificial intelligence-assisted white light imaging for colorectal neoplasia detection: a randomised trial
CONCLUSIONS: AI-assisted colonoscopy demonstrated high ADR and NDR. While without statistical relevance overall, marginal significance was observed for screening patients. →
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Evaluation of safety and efficacy of the combination of mebeverine and sulpiride in treatment of patients with functional gastrointestinal disorders: A prospective cohort
ObjectiveIn this study, we aimed to evaluate the safety and efficacy of a combination of 100 mg mebeverine and 25 mg sulpiride (Colona®) in patients with functional gastrointestinal disorders.MethodsThis multicenter, cohort study was conducted in Egypt, comprising 253 patients diagnosed with functional gastrointestinal disorders. The treatment duration was 2 weeks. The primary endpoint was the… →
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Effects of Artificial Intelligence Recognition-Based Telerehabilitation on Exercise Capacity in Patients With Hypertension: Randomized Controlled Trial
CONCLUSIONS: Compared with conventional exercise rehabilitation, AI-assisted remote rehabilitation was found to improve exercise capacity, boost regular physical activity and exercise self-efficacy, and aid in systolic BP control among patients with hypertension. This study positioned AI-assisted rehabilitation as a scalable and effective strategy for real-world hypertension management. It further contributes actionable guidance for developing effective… →
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Therapeutical efficacy of immunobiotics in patients with newly diagnosed rheumatoid arthritis
CONCLUSIONS: Adjunctive probiotic supplementation with specific strains may enhance clinical outcomes, reduce inflammation, and increase remission rates in early RA, supporting probiotics as a safe, accessible adjunctive therapy. →
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The CEO’s Playbook for Difficult Board Directors
Carolyn Geason-Beissel/MIT SMR | Getty Images Ideally, board meetings feature thoughtful and challenging engagement between the board and CEO as they execute a fundamental responsibility: to lead their company toward sustained value creation. However, board and CEO dynamics often fall short of this ideal. Frequently, the human element in the boardroom is the key issue.… →
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Impact of secukinumab with modified nourishing blood and moisturising decoction on superficial fungal infections in patients with psoriasis with blood-dryness pattern
CONCLUSION: In this study, combining secukinumab with a modified nourishing and moisturising TCM regimen yielded superior clinical outcomes, including greater symptom relief, improved quality of life, and a reduced risk of superficial fungal infections compared with biologic monotherapy. →
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A BOPPPS-based micro-lecture teaching intervention for orthopaedic postgraduates in China
BACKGROUND: Orthopaedics is a highly specialized discipline characterized by complex theoretical frameworks and extensive knowledge, posing challenges for postgraduate teaching. With the advancement of educational technology, micro-lectures have been increasingly adopted in medical education. However, their isolated use may be insufficient to sustain student engagement or ensure effective learning. The bridge-in, learning objective, pre-test, participatory… →