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Central-boost Ablative Radiation Therapy for Solid Tumors: Study Protocol of a Single-arm, Phase II Trial (CBART)
BackgroundThough stereotactic body radiation therapy (SBRT) has been widely used in advanced tumors, ablative doses may not be appropriate in the case of large tumors or those abutting to the gastrointestinal tracts, resulting in unfavorable outcomes. Therefore, partial irradiation with high doses to tumors have been investigated. In order to achieve a larger high dose… →
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Systematic evaluation of the effectiveness of Xuesaitong combined with nutraceutical drugs in the treatment of diabetic peripheral neuropathy
This study aims to evaluate the effectiveness of combining Xuesaitong with nutraceutical drugs, including alpha-lipoic acid, B vitamins, and coenzyme Q10, in the treatment of diabetic peripheral neuropathy (DPN). A 12-week randomized controlled trial was conducted with 140 clinically diagnosed DPN patients, who were randomly assigned into two groups. The intervention group received Xuesaitong along… →
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An auxiliary role of deep neural network ophthalmic disease identification models in choosing medication treatment strategy
To evaluated a Deep Neural Network (DNN)-based ophthalmic disease diagnosis framework in facilitating personalized medication treatment plans using a prospective, single-center, randomized controlled clinical trial design. 500 patients were randomly assigned to either a DNN-aided experimental group or a control group receiving standard physician-based treatment plans. The primary outcomes were medication selection accuracy, clinical efficacy… →
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Application and efficacy analysis of empowerment theory-based Pharmacological intervention in the rehabilitation of children with autism
To explore the application and efficacy of a combined pharmacological and behavioral intervention in the rehabilitation of children with autism, emphasizing individualized treatment approaches. Ninety-six hospitalized children diagnosed with autism, aged 3-8 years, were randomly assigned to an experimental group or a control group. The control group received conventional interventions, including systematic language training, behavioral… →
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Herbal fumigation combined with vessels acupoint improves the prognosis and reduces inflammation in patients with dry eye disease: A retrospective study
Dry eye disease (DED) is a prevalent condition often associated with inflammation and tear film dysfunction. Complementary treatments such as herbal fumigation and acupoint applications have shown promise in handling EDE. This study evaluates the combined efficacy of herbal fumigation and vessels acupoint in treating DED. A total of 123 DED patients were randomly assigned… →
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Meta AI Releases V-JEPA 2: Open-Source Self-Supervised World Models for Understanding, Prediction, and Planning
«`html Meta AI Releases V-JEPA 2: Open-Source Self-Supervised World Models for Understanding, Prediction, and Planning Meta AI has introduced V-JEPA 2, a scalable open-source world model designed to learn from video at internet scale and enable robust visual understanding, future state prediction, and zero-shot planning. Building upon the joint-embedding predictive architecture (JEPA), V-JEPA 2 effectively… →
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Validity and usability for digital cognitive assessment tools to screen for mild cognitive impairment: a randomized crossover trial
CONCLUSIONS: Digital cognitive tests are valid and feasible in PHC settings but face implementation challenges, especially in usability and adaptability among individuals with lower education levels. →
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A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing
Considering the complexity of serotonergic influence on emotions, we conducted a comprehensive investigation of the interplay between emotion processing and the serotonergic system using simultaneous functional and molecular neuroimaging during pharmacological challenge while disentangling the effects of serotonin transporter (SERT) binding, genotype, and diagnosis of major depressive disorder (MDD). Herein, 153 subjects (44 with MDD)… →
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Awareness of baseline functioning and sensitivity to improvement in older people with and without mild cognitive impairment receiving a computerized functional skills training program
CONCLUSIONS: Participants with MCI underestimated their performance deficits at baseline. Self-reports of changes in everyday functioning do not track the substantial objective changes. Previous studies have reported a lack of sensitivity to training gains in several different conditions. Strategies to increase awareness of training gains may be required to sustain treatment benefits. →
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Systemic indocyanine green administration to detect bile leakage after liver surgery: a prospective clinical trial, using historical controls
CONCLUSIONS: Intraoperative ICG administration and assessment effectively lower bilirubin levels in drainage fluid during hepatectomy, potentially reducing the incidence of BL. →
