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Efficacy of Power Training on Sarcopenic Obesity in Community-Dwelling Older Women: A 32-Week Randomized Clinical Trial
Background/Objectives: Exercise is a key nonpharmacological strategy for the management of sarcopenic obesity (SO), characterized by low muscle mass and excess fat. However, long-term interventions and specific modalities, such as power training (PT), remain unexplored in this population. Methods: In this 32-week randomized controlled trial, 40 community-dwelling women (mean age: 77.0 ± 6.8 years) with… →
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Build a Secure AI Code Execution Workflow Using Daytona SDK
Build a Secure AI Code Execution Workflow Using Daytona SDK Build a Secure AI Code Execution Workflow Using Daytona SDK Understanding the Target Audience The target audience for the Daytona SDK tutorial includes software developers, data scientists, and machine learning engineers who are interested in securely executing AI-generated code. Their primary goals are to: Ensure… →
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Apple Researchers Reveal Structural Failures in Large Reasoning Models Using Puzzle-Based Evaluation
«`html Apple Researchers Reveal Structural Failures in Large Reasoning Models Using Puzzle-Based Evaluation Artificial intelligence has evolved from basic language models to advanced systems known as Large Reasoning Models (LRMs). These tools aim to simulate human-like thinking by generating intermediate reasoning steps before arriving at conclusions. This transition has raised critical questions about how these… →
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Google AI Unveils a Hybrid AI-Physics Model for Accurate Regional Climate Risk Forecasts with Better Uncertainty Assessment
«`html Google AI Unveils a Hybrid AI-Physics Model for Accurate Regional Climate Risk Forecasts with Better Uncertainty Assessment Understanding the Target Audience The target audience for this article includes climate scientists, business leaders in agriculture and water resource management, policymakers, and technology enthusiasts interested in AI applications. Their pain points revolve around the limitations of… →
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AI Explainability: How to Avoid Rubber-Stamping Recommendations
For the fourth year in a row, MIT Sloan Management Review and Boston Consulting Group (BCG) have assembled an international panel of AI experts that includes academics and practitioners to help us understand how responsible artificial intelligence (RAI) is being implemented across organizations worldwide. In the spring of 2025, we also fielded a global executive… →
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Implementation of a Quality Improvement and Clinical Decision Support Tool for Cancer Diagnosis in Primary Care: Process Evaluation
CONCLUSIONS: While some components of the intervention, such as the CDS tool, were considered to be acceptable and useful, this process evaluation highlighted barriers such as time and resources, practice differences, and considerations around the optimal amount of support needed when delivering the intervention. Addressing these in future studies may optimize the implementation process. Further… →
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This AI Paper Introduces VLM-R³: A Multimodal Framework for Region Recognition, Reasoning, and Refinement in Visual-Linguistic Tasks
This AI Paper Introduces VLM-R³: A Multimodal Framework for Region Recognition, Reasoning, and Refinement in Visual-Linguistic Tasks Understanding the Target Audience The target audience for this paper primarily consists of AI researchers, data scientists, and business leaders in technology sectors focused on AI and machine learning applications. Their pain points include: Difficulty in achieving high… →
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Pegylated liposomal doxorubicin + cyclophosphamide followed by taxane as adjuvant therapy for early-stage breast cancer: a randomized controlled trial
CONCLUSION: The PLD-based regimen for early-stage BC showed significantly lower rates of elevated hs-cTnT and grade 3-4 AEs with comparable efficacy to the doxorubicin-based regimen. (ClinicalTrials.gov Identifier: NCT03949634; IRB Approved: Ethics committee institutional review board of Shanghai Cancer Hospital, Fudan University’s (No. 1706173-19-1904B) and other center). →
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Netarsudil v/s Ripasudil: The battle of supremacy between two ROCKS-I (rho kinase inhibitors)
CONCLUSION: Topical netarsudil 0.02% once daily was well tolerated with fewer side effects and in reducing IOP than topical ripasudil 0.4% twice daily dosing in POAG patients. Netarsudil 0.02% once daily may be considered an important option for the IOP control in POAG. →
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Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity Profiles of a Single-Dose JYB1904 in Healthy Chinese Participants: A Phase Ia, Randomized, Double-Blind, Placebo-Controlled Study
Allergic asthma, characterized by airborne allergen sensitivity and Th2 immune responses, is a common and increasing global health concern. Omalizumab, while effective, has limitations such as weight- and IgE-dependent dosing regimens. JYB1904, a recombinant anti-IgE humanized monoclonal antibody (IgG1 subtype), showed superior preclinical properties. We performed a single-center, randomized, double-blind, placebo-controlled, single ascending-dose phase Ia… →
