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Fight Versus Flight: When a Leader’s Fears Turn Into Anger
Carolyn Geason-Beissel/MIT SMR | Getty Images You probably understand that the typical responses to fear are fight or flight. Two other options are freeze and fawn, which, like flight, are used by people trying to avoid or minimize a scary situation. In the context of leadership advice, we’ve tended to focus on the flight response… →
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Podcast: Managing Layoffs without Compromising Your Morals
Like it or not, making layoffs is a skill. “ They are just a predictable part of business and they are an important part of building business literacy,” says Brooke Vuckovic, a clinical professor of management and organizations at Kellogg. But middle managers, especially those early in their careers, are still caught off guard when it… →
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Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine
CONCLUSIONS: In healthy U.K. adults who were challenged with S. Paratyphi A in a controlled human infection model, a two-dose series of CVD 1902 led to protection against S. Paratyphi A infection without safety concerns. (Funded by the Medical Research Council; VASP ISRCTN Registry number, 15485902.). →
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European Study of Prostate Cancer Screening — 23-Year Follow-up
CONCLUSIONS: Long-term follow-up confirms a sustained reduction in deaths from prostate cancer with PSA testing, alongside an improved harm-benefit ratio. Future screening strategies should adopt risk-based approaches to minimize overdiagnosis while maintaining clinical benefits. (Funded by the Dutch Cancer Society and others; ERSPC ISRCTN registry number, ISRCTN49127736.). →
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Intended isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight
Time-restricted eating (TRE) is a promising strategy to improve metabolic outcomes. However, it remains unclear whether TRE has cardiometabolic benefits in an isocaloric setting and whether its effects depend on the eating timing. We conducted a randomized crossover trial in 31 women with overweight or obesity to directly compare the effects of a 2-week early… →
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Association between intraoperative hypotension during brain tumor resection and postoperative delirium: A secondary analysis of a randomized controlled trial
CONCLUSIONS: The current results could not indicate intraoperative hypotension of mean arterial pressure lower than 65 mmHg associated with delirium after frontotemporal brain tumor resection. →
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Microsoft Releases Agent Lightning: A New AI Framework that Enables Reinforcement Learning (RL)-based Training of LLMs for Any AI Agent
Microsoft Releases Agent Lightning: A New AI Framework that Enables Reinforcement Learning (RL)-based Training of LLMs for Any AI Agent Understanding the Target Audience The target audience for Microsoft’s Agent Lightning comprises AI developers, product managers, and business executives in tech sectors focusing on AI applications. These individuals are primarily concerned with integrating AI solutions… →
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Brief Video Intervention to Increase Treatment-Seeking Intentions Among Young Adults With Psychiatric Symptoms: A Randomized Controlled Trial
Objective: Brief social contact-based video interventions are effective in decreasing self-stigma and increasing treatment-seeking intentions. The present study is the first to target essential workers with self-reported anxiety, depression, and posttraumatic stress disorder (PTSD) symptoms during the COVID-19 pandemic. We hypothesized that viewers of the intervention would show greater increases in treatment-seeking intentions than nonviewers… →
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Multi-wave locked system laser therapy in chronic non-specific neck pain: a double-blind placebo randomized-controlled trial
CONCLUSIONS: Both MLS Laser and Sham Laser therapies resulted in statistically significant improvements in pain, disability, and movement velocity. However, these changes were not clinically meaningful. MLS Laser therapy provided more pronounced and sustained pain relief and improved range of motion in head movements. →
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Cost-utility analysis of a polylactic acid matrix versus a collagen dressing for the closure of diabetic foot ulcers
CONCLUSION: PLA dermal matrices provide a cost-effective alternative to collagen dressings, promoting faster wound closure, improved quality of life, and reduced healthcare costs. These results support the adoption of PLA as a preferred treatment for DFUs. →
