-
Lending a hand: supportive exercise therapy for cancer treatment-induced polyneuropathy of the upper extremity-VISCIPH A
CONCLUSION: While prior research has mainly focused on lower extremities, this study demonstrates the feasibility and potential protective effects of a combined vibration and sensorimotor training protocol for the upper limbs during neurotoxic cancer therapy. Given the limited efficacy of current pharmacological approaches, further research is warranted to explore the therapeutic potential of structured exercise… →
-
Cell-Based Ciliary Neurotrophic Factor Therapy for Macular Telangiectasia Type 2
CONCLUSIONS: NT-501 for MacTel resulted in statistically significantly reduced EZA loss compared with sham procedures. (Funded by Neurotech Pharmaceuticals; ClinicalTrials.gov numbers, NCT03316300 and NCT03319849.). →
-
AI Guardrails and Trustworthy LLM Evaluation: Building Responsible AI Systems
«`html AI Guardrails and Trustworthy LLM Evaluation: Building Responsible AI Systems Introduction: The Rising Need for AI Guardrails As large language models (LLMs) grow in capability and deployment scale, the risk of unintended behavior, hallucinations, and harmful outputs increases. The recent surge in real-world AI integrations across healthcare, finance, education, and defense sectors amplifies the… →
-
Qwen Releases Qwen3-Coder-480B-A35B-Instruct: Its Most Powerful Open Agentic Code Model Yet
«`html Qwen Releases Qwen3-Coder-480B-A35B-Instruct: Its Most Powerful Open Agentic Code Model Yet Introduction Qwen has unveiled Qwen3-Coder-480B-A35B-Instruct, their most powerful open agentic code model released to date. With a distinctive Mixture-of-Experts (MoE) architecture and comprehensive agentic coding capabilities, Qwen3-Coder sets a new standard for open-source coding models and redefines what’s possible for large-scale, autonomous developer… →
-
Eight Essential MIT SMR Reads on Culture
Amid great change and great demands, a strong workplace culture has never been more vital. Many people have endured negative work experiences: the monotony of uninspiring tasks, the absence of genuine camaraderie, or unclear, disjointed expectations that leave employees feeling unmoored. At the other end of the spectrum, the most powerful endorsement a workplace can… →
-
Are We Ready for Production-Grade Apps With Vibe Coding? A Look at the Replit Fiasco
«`html Are We Ready for Production-Grade Apps With Vibe Coding? A Look at the Replit Fiasco The Allure and The Hype Vibe coding—constructing applications through conversational AI rather than writing traditional code—has surged in popularity, with platforms like Replit promoting themselves as safe havens for this trend. The promise: democratized software creation, fast development cycles,… →
-
Building a Versatile Multi‑Tool AI Agent Using Lightweight Hugging Face Models
«`html Building a Versatile Multi-Tool AI Agent Using Lightweight Hugging Face Models In this tutorial, we will set up a compact yet capable AI agent that runs smoothly, leveraging Hugging Face transformers. We will integrate dialog generation, question-answering, sentiment analysis, web search stubs, weather look-ups, and a safe calculator into a single Python class. Throughout… →
-
Context Engineering for AI Agents: Key Lessons from Manus
«`html Context Engineering for AI Agents: Key Lessons from Manus Building effective AI agents involves more than selecting a powerful language model. The Manus project highlights that the design and management of the “context” – the information the AI processes to make decisions – is crucial. This “context engineering” significantly impacts an agent’s speed, cost,… →
-
Exploratory analyses of meal-induced heartburn identify distinct clinical phenotypes of gastroesophageal reflux disease
Symptoms in symptomatic GERD patients result from esophageal acid exposure and are treated with agents that inhibit gastric acid secretion. We analyzed data from a clinical trial evaluating the effect of ranitidine plus antacid on heartburn severity in GERD patients. After 26 subjects ingested a standard meal and received either placebo or ranitidine-antacid, heartburn severity… →
-
Long-term dosage effects of psychodynamic and schema therapy in depressed patients with personality disorders: 18 and 24 months follow-up of a randomized controlled trial
CONCLUSIONS: Higher psychotherapy dosage led to faster initial improvements, but long-term outcomes were not superior to those achieved with a lower dosage. These results should be interpreted with caution, as unregulated treatment during follow-up reduced the power to detect significant dosage effects. Both SPSP and ST provide viable alternatives to treatments focused solely on depression. →
