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Clinical and radiographic evaluation of premixed bioceramic putty as an apical plug in nonvital immature anterior permanent teeth
Achieving an apical seal is critical for apexification treatment of nonvital immature teeth. While this is commonly accomplished using biocompatible mineral trioxide aggregate (MTA), its limitations, such as prolonged setting time, discoloration, and challenging handling, have driven the search for alternative materials. This study aimed to compare the clinical and radiographic success of bioceramic putty… →
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‘A post-test experimental study on the effects of message framing and the use of a patient testimonial on intentions of osteoarthritis patients to adhere to treatment advice’
CONCLUSION: This study suggests that describing the disadvantages of nonadherence to pain medication resulted in more positive beliefs about pain medication than stating the advantages of adherence. The use of a patient testimonial within this loss-frame strengthened the effect. Our findings indicate that the use of framing and testimonials in OA care can matter and… →
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Comparison of gadobutrol and meglumine gadoterate for dynamic contrast-enhanced MRI of pituitary macroadenomas
In this study, we compared the performance of gadobutrol and meglumine gadoterate, two macrocyclic non-ionic and ionic contrast agents, for evaluating quantitative perfusion parameters of pituitary macroadenomas using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Patients with pituitary macroadenomas were prospectively enrolled and randomly assigned to be administered gadobutrol or meglumine gadoterate for MRI. Perfusion parameters… →
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Exploratory phase II trial of an anti-PD-1 antibody camrelizumab combined with a VEGFR-2 inhibitor apatinib and chemotherapy as a neoadjuvant therapy for triple-negative breast cancer (NeoPanDa03): efficacy, safety and biomarker analysis
Chemotherapy serves as the primary therapeutic approach for triple-negative breast cancer (TNBC), yet its efficacy remains unsatisfactory. This study was a single-arm, open-label, single-center clinical trial (NCT05447702) involving patients with newly diagnosed stage II-III TNBC at West China Hospital. The treatment regimen consisted of camrelizumab (200 mg intravenously every 2 weeks, 12 cycles), apatinib (250… →
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Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial
Leveraging adaptive tumour immunity to control mesothelioma via immune checkpoint blockade is now a standard therapeutic approach. However, the determinants of sensitivity remain elusive. Low non-synonymous mutation burden and programmed death-ligand 1 expression, an abundance of immunosuppressive immune cell infiltration, and 9p21 deletion should all mitigate responses to therapy. To address this knowledge gap, we… →
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Top 15+ Most Affordable Proxy Providers 2025
«`html Top 15+ Most Affordable Proxy Providers 2025 The global proxy market is experiencing rapid expansion in 2025, with the industry estimated to be valued at $2.5 billion and exhibiting a robust growth rate of 18% compound annual growth rate (CAGR). This growth is driven by the booming demand for residential proxies, real-time data collection… →
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The Ultimate Guide to Vibe Coding: Benefits, Tools, and Future Trends
«`html The Ultimate Guide to Vibe Coding: Benefits, Tools, and Future Trends Introduction Vibe Coding is redefining the software landscape by harnessing artificial intelligence to make code creation faster, more intuitive, and accessible to virtually anyone. In 2025, this trend has moved from buzzword to mainstream, ushering in a new era where software projects ride… →
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A Strategy-First Approach to Talent Systems and Decisions
Commercial digitalized talent management (DTM) systems promise to streamline talent decisions by providing best-practice frameworks for objectively identifying talent. But when we rely too heavily on these systems, we risk outsourcing critical strategic decisions to algorithms that don’t account for the nuances of your culture or strategic goals. So how can executives effectively design fit-for-purpose… →
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How I Built a Personal Board of Directors With GenAI
Leadership experts have long championed the concept of a personal board of directors as a way for executives to surround themselves with a circle of trusted mentors, sponsors, and advisers. I’ve advocated for and practiced this model myself during the past several years. But here’s the twist: What if your board members didn’t have to… →