CONCLUSIONS: Aspirin led to a significantly lower incidence of colorectal cancer recurrence than placebo among patients with PIK3CA hotspot mutations in exon 9 or 20 and appeared to have a similar benefit among those with other somatic alterations in PI3K pathway genes. (Funded by the Swedish Research Council and others; ALASCCA ClinicalTrials.gov number, NCT02647099; EudraCT… →

CONCLUSION: In patients with PCa otherwise suitable for management with focal therapy, a high GC score (≥0.45) was independently associated with treatment failure. A GC score derived from diagnostic biopsy can be used to help predict focal therapy outcomes. →

CONCLUSION: Our study found that PZ biopsies offer no additional benefit for TZ lesion tumors, and increasing the number of cores in the TZ region can compensate for the current limitations of TZ biopsies. These findings provide potential avenues for optimizing biopsy strategies for TZ lesions. →

Attention-Deficit/Hyperactivity Disorder (ADHD) is defined by impairing levels of inattention and/or hyperactivity-impulsivity. It occurs in at least 5% of school age children and 2.5% of adults worldwide, and is associated with multiple negative outcomes throughout life. There is good evidence to support the efficacy of pharmacological treatment of individuals affected, and also of behavioural training… →

The learning curve for endoscopic diagnosis varies, and an optimal educational strategy is not available. Working memory (WM) refers to an individual’s ability to store and process information quickly and simultaneously. This study aimed to determine whether educational methods, optimized by individual WM, facilitate learning about endoscopic diagnoses. In the development phase, the standard WM… →

CONCLUSION: The findings of this study confirm PRP as a viable treatment option for AGA. Both injection and microneedling methods provided therapeutic benefits. Additionally, microneedling appeared to enhance patient satisfaction and treatment tolerance. →