CONCLUSIONS AND RELEVANCE: This economic evaluation found that for remission, both PPOIT and OIT were cost-effective and good value compared with no treatment, with OIT associated with a larger effect size but no clinically meaningful difference. When QALYs are prioritized, PPOIT offers the best value. Key factors associated with cost-effectiveness were treatment product pricing and… →

CONCLUSION: Inhaled NO therapy in complex therapy of PE demonstrated safety and efficacy in relation to clinical, functional and laboratory parameters. →

CONCLUSION: Cipepofol exhibited no clinically relevant effects on the QTc interval or other ECG parameters, and was safe and well tolerated in healthy subjects. →

CONCLUSION: The one-step 75 g OGTT increases diagnostic labeling without improving short-term clinical outcomes. Post-load OGTT values-particularly 2-hour glucose levels-provide the most clinically meaningful prognostic information and may support a risk-stratified approach to GDM management rather than expansion of diagnostic thresholds alone. →

BACKGROUND: This study aimed to test whether the Meaning-Making intervention (MMi) increases the sense of meaning in life in people newly diagnosed with any type of advanced cancer. →

CONCLUSION: pTDM is very likely a cost-effective treatment strategy for patients with immune-mediated inflammatory diseases on infliximab maintenance therapy. →

CONCLUSIONS: The home-based DEP following Achilles tendon repair provided comparable clinical outcomes to traditional physiotherapy while significantly improving cost-effectiveness. These findings support the broader adoption of tele-supervised digital rehabilitation as a safe and effective alternative. →

CONCLUSIONS: The innovative patient education model integrating AI voice cloning and ChatGPT is distinct from previous studies primarily relying on standard text-to-speech or professionally recorded content. Using patients’ own cloned voices for health education delivery leveraged the self-reference effect to enhance learning outcomes. Compared with research using clinician-narrated content, this study highlights that self-voice education… →

CONCLUSION: The VISCIPH B pilot trial confirmed the feasibility, safety, and acceptance of supervised exercise for upper-extremity PNP in cancer patients. Significant improvements in patient-reported and functional outcomes indicate that combined sensorimotor and vibration exercise can meaningfully reduce PNP symptoms and should be evaluated in larger trials. →