Clinical Trials
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Lessons Learned from Sepsis Microlearning Intervention
Improving early recognition and treatment of sepsis is key to decreasing patient mortality. A large academic health system implemented several quality improvement initiatives, yet monthly compliance with sepsis best practices remained low.Develop and evaluate an electronic health record (EHR)-embedded microlearning intervention to address suboptimal adherence to sepsis care best practices.We conducted a randomized stepped-wedge trial…
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Efficacy and safety of ultrasonic bone scalpel in posterior cervical expansive open-door laminoplasty for cervical degenerative diseases: A prospective randomized controlled trial
BackgroundKey instruments used in posterior cervical expansive open-door laminoplasty (CEOL), such as the high-speed drill (HSD) and the ultrasonic bone scalpel (UBS), are selected based on surgeon preference. However, skepticism remains among some surgeons regarding the superiority of the HSD over the widely used UBS, necessitating a scientific evaluation of its practical utility.ObjectiveTo evaluate the…
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Vonoprazan-containing Dual and Triple Therapies are Non-inferior to Bismuth-quadruple Therapy for Helicobacter pylori Eradication: A Single-center, Prospective, Open-label, Real-World Study
CONCLUSIONS: Efficacy of the two Vo-containing regimens was comparable and non-inferior to the BQT in this region, and could serve as the first-line regimen for H. pylori eradication, and reduced use of one antibiotic per each patient treatment in real-world clinical application.
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Five-year radiographic and clinical outcomes after arthroscopic synovectomy of the ankle in rheumatoid arthritis: A clinical trial
CONCLUSIONS: Arthroscopic synovectomy improves symptoms for ankle RA and appears to slow-but not halt-radiographic deterioration over 5 years. Serial PRP injections and reduction in BMI from baseline could be associated with better clinical outcomes and slower joint degeneration, which needs to be verified by randomized controlled trials.
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Traditional healers can help facilitate HIV serostatus disclosure: results from a qualitative study in rural Uganda
CONCLUSIONS: THs provide a culturally sensitive and trusted avenue for HIV status disclosure in rural Uganda. Their unique position within the community allows them to address stigma, build trust and facilitate safe disclosure practices. Integrating healers into HIV care through training and collaboration with formal healthcare systems could enhance linkage, adherence, retention and overall care…
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The effectiveness of physical activity intervention on mobile phone addiction in college students: the chain mediating role of emotion regulation strategies and positive coping style
CONCLUSION: Compared with single-form exercise, combined PA is more effective in alleviating mobile phone addiction among college students, primarily through the chain mediating effects of improved emotion regulation strategies and enhanced positive coping styles. It is recommended that universities and relevant institutions promote combined physical activities to help college students reduce mobile phone addiction and…
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Swallowing prehabilitation for people with head and neck cancer: a pilot cluster-randomised feasibility trial of the SIP SMART intervention
CONCLUSIONS: It is feasible to deliver the SIP SMART intervention embedded within the NHS cancer care pathway using a cluster-randomised design. A future trial will be optimised for efficiency in set-up and follow-up data collection based on these findings and learnings from the accompanying process evaluation study.
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Secondary Distribution of Dual HIV/Syphilis Self-Testing Among Men Who Have Sex With Men: Pragmatic Randomized Controlled Trial in China
CONCLUSIONS: Our data demonstrate that the secondary distribution strategy of HIV/syphilis self-testing proves to be an effective means of expanding HIV testing coverage by encouraging the distribution of testing kits within the social networks of MSM.
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Photodynamic Therapy for Peripheral Lung Cancer
Photodynamic therapy (PDT) utilizes a tumor-specific photosensitizer with low-power laser irradiation and this treatment has been established for centrally located lung cancers. However, its application to peripheral type lung cancers remains investigational. Recently, there has been interest in minimally invasive ablative therapies are needed for peripheral type lung cancer and several bronchoscopic ablative modalities are…
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Effects of Phenytoin on the Retinal Ganglion Cell-Inner Plexiform Layer in Acute Optic Neuritis: Analysis of a Phase II Randomized Trial
BACKGROUND AND OBJECTIVES: Acute demyelinating optic neuritis (AON) can lead to irreversible neuroaxonal loss. We investigated the neuroprotective effects of phenytoin on macular ganglion cell-inner plexiform layer (mGCIPL) thickness.