Clinical Trials
Category Added in a WPeMatico Campaign
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Brexpiprazole for the Treatment of Co-occurring Schizophrenia and Substance Use Disorder: A Multisite, Randomized, Controlled Trial
Objective: This proof-of-concept study examined the effects of brexpiprazole treatment on substance use, psychiatric symptoms, and quality of life in patients with co-occurring schizophrenia and substance use disorder.
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Safety and efficacy of ranibizumab combined with dexamethasone intravitreal implant versus ranibizumab monotherapy for macular edema secondary to retinal vein occlusion: a 12-month prospective, randomized study
CONCLUSION: Combination therapy with ranibizumab and a dexamethasone implant provides superior visual outcomes and reduces the treatment burden compared to ranibizumab monotherapy for RVO-ME over 12 months. The safety profile was favorable, though monitoring for ocular hypertension is necessary. These benefits are particularly significant for patients with BRVO-ME.
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Oxycodone versus Sufentanil for Postoperative Recovery in Obese Patients Undergoing Laparoscopic Bariatric Surgery: A Randomized Controlled Trial
CONCLUSION: Oxycodone significantly enhanced postoperative recovery quality compared with sufentanil in obese patients undergoing laparoscopic bariatric surgery, providing superior analgesia and reducing opioid-related side effects.
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Effects of melatonin on advanced glycation end products, inflammation, and oxidative stress in peritoneal dialysis patients: a randomized controlled trial
Advanced glycation end products, systemic and vascular inflammation, and oxidative stress are risk factors for cardiovascular disease in peritoneal dialysis (PD) patients. No studies have examined the effects of melatonin on these risk factors in PD patients. This study was a randomized clinical trial. Forty-four PD patients were randomly assigned to either the melatonin or…
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Effect of orally administered L. crispatus M247 in favoring HR-HPV clearance and CST shift: results from a randomized, multi-center, placebo-controlled trial
Epidemiological evidence support the idea that CST I, L. crispatus-dominated vaginal microbiota, could protect women form cervical HPV infection also favoring the HPV clearance. Our prospective, multi-center, randomized, placebo-controlled trial on 62 women newly diagnosed of HPV infection without visible cervical lesions at colposcopy, was mainly aimed at evaluating the role exerted by the oral…
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Proactive Identification and Digital Mental Health Intervention for the Treatment of Depression Among Individuals With Likely Incurable Cancer: A Pilot Randomized Clinical Trial
CONCLUSIONS: A proactive ID + DMHI approach to identifying and treating depression among ILLIC is feasible, acceptable, and potentially efficacious. These promising data support conducting a large efficacy trial evaluating this approach.
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Changes in frailty based on minimally important difference and the impact of spironolactone on frailty in heart failure with preserved ejection fraction: insights from the TOPCAT trial
CONCLUSIONS: Frailty improvement exceeding the 0.03 FI threshold predicts better prognosis in HFpEF, underscoring the value of routine assessment. Spironolactone use was associated with neutral effects on frailty progression in our analysis, suggesting potential safety in this vulnerable population.
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Sustained resolution of enthesitis and peripheral arthritis over 104 weeks with bimekizumab in axial spondyloarthritis
CONCLUSION: BKZ resulted in sustained improvements in peripheral manifestations to 2 years across the full disease spectrum of axSpA.
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Reduced Chronic Obstructive Pulmonary Disease-Related Utilization of Health Care Services and Increased Social Activities by Patients Offered a 24/7 Accessible Telehealth Service Based on the Epital Care Model: Pragmatic Modified Stepped Wedge Randomized Controlled Trial
CONCLUSIONS: These results contribute to a new perspective on how health care services can be organized to reduce health care usage and increase social activity and mobility based on an ECTHS manned with nonprofessional certified staff.
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Implementing a single-person virtual Trier social stress test via zoom: validation and outcomes
The Trier Social Stress Test (TSST) reliably induces psychosocial stress, but its high resource demands limit its applicability in many research contexts. We evaluated a single-person videoconference TSST (vcTSST) delivered via Zoom using pre-recorded «jury» members. Forty-one healthy, German-speaking students were randomized to vcTSST (n = 21) or a structurally matched control (n = 20).…