Clinical Trials
Category Added in a WPeMatico Campaign
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Factors associated with distress over time in women with breast cancer undergoing radiotherapy: insights from a pilot study assessing a digital information tool
CONCLUSION: The results indicate no statistically significant effect on distress; however, there is a potential indication of a reduction in distress, suggesting that the digital information tool may offer some benefits. Further research is required to confirm this relationship.
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Association of Intraoperative Hypotension with Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery: A Secondary Analysis of a Randomized Trial
CONCLUSIONS: Intraoperative hypotension was not associated with PONV in patients at high risk of PONV who underwent laparoscopic gastrointestinal surgery.
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Two is Better Than One: Potentiating Cognitive Remediation With Aerobic Exercise to Improve Cognition in Schizophrenia With a Randomized Controlled Trial
CONCLUSIONS: While preliminary, these findings suggest that a combined intervention of CR+AE allows greater improvements across core cognitive domains. In a wider perspective, this study also underscores the potential value of implementing aerobic exercise in rehabilitative approaches aimed at addressing cognitive dysfunction in schizophrenia.
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Spinal Anaesthesia Versus General Anaesthesia for Patients With Tibia Shaft Fractures-A Randomized Controlled Study
CONCLUSION: Spinal anaesthesia was not associated with higher compartment pressures compared to general anaesthesia. These findings suggest that prevailing concerns and recommendations about spinal anaesthesia for tibia shaft fracture surgery may need reconsideration and challenge recommendations favouring general anaesthesia as the primary method.
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Reducing blood pressure variability-results from a single-arm proof of concept prospective trial
Increased variability in systolic blood pressure, expressed as the coefficient of variation (BPCoV), is associated with poor cardiovascular outcomes. Variability could be due to episodic non-adherence to medical recommendations in some patients. Reports of targeted attempts to mitigate such variation are lacking. A behavioral intervention targeted at patients with initially high BPCoV may decrease variability.…
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Assessing participants’ experiences with the COVID-19 symptom diary in a clinical trial
During a phase 2/3 study of twice-daily nirmatrelvir 300 mg coadministered with ritonavir 100 mg versus placebo for 5 days (NCT05011513), participants reported presence and severity of COVID-19 symptoms using a COVID-19 symptom diary in accordance with FDA guidance. Here, we aimed to evaluate the content validity of the COVID-19 symptom diary and global impression…
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Clinical efficacy of endocrinotherapy combined with Shenqi Pills on patients with hormone-sensitive prostate cancer
CONCLUSION: Endocrinotherapy combined with Shenqi Pills is safe and effective in HSPC and can reduce the risk of death in HSPC patients, and the earlier the intervention, the longer the overall survival of the patients. In addition, this treatment regimen can increase the PSA response rate, improve patients’ quality of life, and reduce the renal-yang…
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Study on the treatment of chronic nonbacterial prostatitis caused by dampness-heat stasis with Oxalis Formula combined with transacupuncture
CONCLUSION: The combination of Oxalicao Formula and transacupuncture for treating CNP characterized by dampness-heat stasis demonstrates significant therapeutic benefits, which has considerable clinical application value.
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Psychological intervention based on the extension and expansion of positive psychology model improves psychosexual resilience and erectile function in patients with psychogenic ED
CONCLUSION: For the treatment of pED, PERMA-based psychological intervention in addition to active medication contributes to elevating the psychological resilience and improving the erectile function of the patients.
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Sertraline hydrochloride combined with compound chamomile lidocaine gel for the treatment of premature ejaculation
CONCLUSION: Sertraline hydrochloride combined with compound chamomile lidocaine gel is definitely effective in the treatment of PE, which can significantly improve the patients’ quality of sexual life, with a high safety and low incidence of adverse reactions.