Clinical Trials
Category Added in a WPeMatico Campaign
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The effect of different obturation techniques on post-obturation pain and sealer extrusion in single-visit root canal treatment: a prospective clinical randomized study
CONCLUSION: The postoperative pain score after Single-Visit RCT for patient diagnosed as asymptomatic irreversible pulpitis was low to moderate pain score, presence of sealer extrusion increased the postoperative pain intensity. Regardless the type of sealer, different obturation techniques did not associated with postoperative pain intensity, while regardless the obturation technique, AH Plus sealer was associated…
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5-Year Outcomes With a Novel Coronary Sirolimus-Eluting Bioresorbable Scaffold: The NeoVas Randomized Trial
CONCLUSIONS: At 5-year follow-up, target lesion failure and stent thrombosis rates were comparable after NeoVas BRS and CoCr EES implantation in noncomplex lesions. However, comparability or the potential signs of harm of NeoVas BRS should be investigated in appropriately sized randomized trials in the future. (NeoVas Bioresorbable Coronary Scaffold Randomized Controlled Trial; NCT02305485).
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Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease
CONCLUSIONS: Patients with chronic coronary disease and angina experienced diverse symptom trajectories, ranging from rapid resolution to severe or persistent angina. A greater proportion of conservatively managed patients experienced unfavorable angina patterns over 2 years compared with those treated invasively. When health status is monitored over time, such patterns may help identify patients with persistent…
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Investigating Learning Effects Through the Implementation of Teledermatology Consultations Among General Practitioners in Germany: Mixed Methods Process Evaluation
CONCLUSIONS: TCs have been shown to be an effective method of education for GPs in terms of «learning on the job» in daily practice. The telemedicine approach seems to be an easily implementable and effective tool to support continuing medical education in the field of dermatology. Strategies could be developed to train GPs and medical…
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Maintaining independence at home after a fall: a process evaluation of the MAINTAIN multicomponent intervention for people living with dementia
CONCLUSIONS: MAINTAIN was both feasible and acceptable. Future studies should consider standardising multidisciplinary support, incorporating targeted falls-related anxiety support and establishing sustainable post-intervention maintenance strategies. Protocol adaptations, such as video consultations, showed promise in addressing workforce constraints.
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Cerebellar Stimulation Modulates Reward Processing: A High-definition Transcranial Direct Current Stimulation Study
Reward processing involves several components, including reward anticipation, cost-effort computation, reward consumption, reward sensitivity, and reward learning. Recent research has highlighted the cerebellum’s role in reward processing. This study aimed to investigate the effects of cerebellar stimulation on reward processing using high-definition transcranial direct current stimulation (HD-tDCS). In this single-blind, randomized, sham-controlled study, 63 healthy…
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Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Living-Donor Nephrectomy
CONCLUSIONS: Although erector spinae plane blocks applied under bilateral ultrasonographic guidance did not have any efficacy for pain relief in the first 24 hours postoperation, a decrease was found in analgesic consumption compared with the nonblock group.
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Randomized Clinical Trial on the Efficacy of Oral Tranexamic Acid Versus Topical Tranexamic Acid in Treatment of Melasma
CONCLUSION: Both forms of TXA are effective with low side effects. The choice between oral and topical TXA can depend on patient preference and convenience.
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Digital Psychological Intervention for Inflammatory Rheumatic Diseases: A Pilot Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This pilot randomized clinical trial supports the effectiveness and safety of a digital psychological intervention in individuals with IRDs. These findings suggest that such digital interventions could be a valuable, scalable approach to addressing mental health needs in rheumatology.
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In-the-Bag Behavior of a New Aspheric Hydrophobic Acrylic Toric Intraocular Lens
CONCLUSIONS: Tilt and decentration of the Clareon TIOL were generally low and a strong correlation was found between crystalline lens tilt and TIOL tilt at 6 months.