Clinical Trials
Category Added in a WPeMatico Campaign
-
Statin Use in Patients With Advanced Prostate Cancer in the TITAN and SPARTAN Trials
CONCLUSIONS AND RELEVANCE: In this cohort study, statin exposure was associated with longer OS in patients treated with apalutamide. Statin-exposed patients had a higher risk of grade 3 or greater cardiac AEs, which may reflect their preexisting cardiovascular comorbidity.
-
Dynamics of the EZ/RPE Loss Ratio on OCT Over Time During Geographic Atrophy Progression and Treatment With Pegcetacoplan
CONCLUSIONS: The change in EZ/RPE loss ratios at month 12 remained to be predictive for disease activity and therapeutic response, providing insights into disease mechanisms and relevant guidance for GA management in clinical practice. The EZ/RPE loss ratio decreased either due to advanced GA or induced by therapy in treated patients versus sham.
-
Yoga as a pre-treatment of EMDR to treat childhood abuse-related PTSD: feasibility and pilot study
Background: Yoga, a mind-body practice that enhances emotional regulation and self-awareness, may be an effective stabilisation tool for trauma-focused therapy, particularly for patients with childhood abuse-related posttraumatic stress disorder (CA-PTSD), who exhibit strong avoidance strategies.Objective: This study aimed to test the efficacy of group yoga sessions followed by individual EMDR sessions on PTSD symptoms. Secondary…
-
A post-market, cluster randomised controlled trial of the effect of the TENA SmartCare Change Indicator on continence care efficiency and skin health in nursing homes
BACKGROUND: Urinary Incontinence (UI) is highly prevalent in older residents of nursing homes. For many, management consists of using appropriate products (pads) maintained by a check and change regimen; this is often poorly managed. Digital health technology devices, like urine saturation sensors, may aid ensure timely change of pads. This study examined the efficacy and…
-
Evaluating relapse prophylaxis in addition to interdisciplinary multimodal pain therapy for back pain: a randomised controlled trial
CONCLUSION: Findings of this study show improvements in the secondary outcomes. The results indicate that further studies are needed to determine how to sustainably reduce days off work due to back pain.
-
Physical fitness and clinically assessed disease burden in long-term childhood cancer survivors-The SURfit study
CONCLUSION: CCS participating in an exercise intervention trial experienced a high burden of adverse health outcomes. Increased physical fitness was associated with reduced disease burden for all survivors, emphasizing the importance of encouraging fitness improvements, regardless of cancer history.
-
Efficacy and safety of upadacitinib as monotherapy or combined with elsubrutinib for the treatment of systemic lupus erythematosus: results through 104 weeks in a long-term extension study
CONCLUSIONS: In this LTE study, upadacitinib monotherapy and upadacitinib/elsubrutinib combined were well tolerated and continued to demonstrate beneficial effects on SLE disease activity, glucocorticoid dose and flares through 104 weeks.
-
Oestrogen replacement combined with resistance exercise in older women with knee osteoarthritis: a randomised, double-blind, placebo-controlled clinical trial
CONCLUSIONS: ERT did not confer significant additive benefits to resistance exercise overall but may improve outcomes in early-stage KOA and mental health domains. These exploratory findings warrant further investigation.
-
Minimal vs Specialized Exercise Equipment for Pulmonary Rehabilitation: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This randomized clinical trial found that PR-min demonstrated noninferiority to PR-gym for exercise capacity, dyspnea, and health-related quality of life. PR-min can expand the number of settings where PR can be provided, thus improving patient accessibility.
-
Effects of occupational therapy on hand function in patients with systemic sclerosis: a randomized controlled trial
Hand involvement is one of the most disabling features of systemic sclerosis (SSc). Although occupational therapy is frequently employed in rheumatic conditions, its particular effects in SSc have not been studied in detail yet. This study aimed to evaluate the impact of a structured three-week occupational therapy program on hand function in SSc. This randomized…