Clinical Trials
Category Added in a WPeMatico Campaign
-
Blunted anterior midcingulate response to reward in opioid users is normalized by prefrontal transcranial magnetic stimulation
Abnormalities in goal-directed behavior, mediated by mesocorticolimbic reward system, contribute to worse clinical outcomes including higher risk of treatment dropout and drug relapse in opioid users (OU). Despite efforts to counteract such neural alterations, brain-based interventions for this disorder remain ineffective. In this sham-controlled randomized study, we report the initial results on the efficacy of…
-
Early childhood caries intervention in Aboriginal Australian children: Follow-up at child age 9 years
CONCLUSION: The present study suggests that, within this cohort, initiating an early childhood caries intervention during pregnancy and infancy may be associated with lower caries experience in the primary dentition by age 9 years compared to a later start. Low maternal education level was associated with caries severity in both primary and permanent dentitions. Sugar…
-
Efficacy of N-acetylcysteine vs dexamethasone in preventing postembolization syndrome post-transarterial chemoembolization in hepatocellular carcinoma: A randomized controlled trial
CONCLUSION: Compared with DEXA, NAC significantly reduces the incidence of PES, regardless of its impact on liver function recovery. Therefore, NAC is a preferable option for reducing PES in Barcelona Clinic Liver Cancer-B stage HCC patients with preserved liver function.
-
Efficacy of a Multimodal Ayurveda Regimen in the Management of Primary Knee Osteoarthritis: Protocol for an Open-Label Randomized Controlled Trial
CONCLUSIONS: This randomized controlled trial will be the first study to explore the potential benefits of a multimodal Ayurveda regimen (based on Ayurveda principles and scientific evidence) in the long-term management of osteoarthritis of the knee through validated subjective, laboratory, and imaging parameters. The outcomes of this study may address the needs and challenges associated…
-
AI-driven early detection of severe influenza in Jiangsu, China: a deep learning model validated through the design of multi-center clinical trials and prospective real-world deployment
BACKGROUND: Influenza-related global deaths reach 650,000 annually. The current highly lethal clinical subtype of influenza is severe influenza.
-
A prospective controlled study on degenerative lumbar spondylolisthesis treated with three steps and nine methods combined with physiotherapy
CONCLUSION: The Three-Step Nine-Method Lumbar Correction combined with physical therapy has a definite efficacy in the treatment of DLS. It can significantly relieve pain symptoms, improve physical function and patients’ quality of life. Its effect is better than that of pelvic traction combined with physical therapy, and it has high safety. However, its improvement on…
-
Functional Connectivity Predicting Transdiagnostic Treatment Outcomes in Internalizing Psychopathologies
CONCLUSIONS AND RELEVANCE: In this prognostic study assessing predictive models of 181 patients with IPs, whole-brain FC reliably predicted multidimensional treatment outcomes across diagnoses and treatment modalities. These results suggest an association between neural connectivity patterns within specific neural networks and clinical improvements induced by varying treatment modalities, thereby advancing efforts toward personalized treatment approaches…
-
Evaluation of the therapeutic effects of Er:YAG laser with different parameters on peri-implantitis
This study evaluates the therapeutic effects of erbium-doped yttrium aluminum garnet (Er:YAG) laser treatment at different energy settings on peri-implantitis in a randomized clinical setting. Forty patients diagnosed with permanent molar fissure caries were randomly assigned to 5 treatment groups, each receiving a distinct treatment protocol. The effectiveness of these interventions was evaluated by comparing…
-
The effect of psychological intervention combined with standard pharmacological therapy in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): A randomized controlled trial
CONCLUSION: The combination of PI and conventional antibiotics is effective for CP/CPPS patients with longer disease course and more severe symptoms. Early PI is recommended to achieve better therapeutic results.
-
Evaluation of the effects of delayed cord clamping in neonates with intrauterine growth restriction
To assess the effects of delayed cord clamping (DCC) at birth on newborns diagnosed with intrauterine growth restriction (IUGR). This prospective, randomized, controlled study included newborns diagnosed with IUGR during pregnancy follow-up and born at a gestational age of ≥28 weeks. Early cord clamping (ECC) was performed immediately after birth, whereas DCC was performed 60…