Clinical Trials
Category Added in a WPeMatico Campaign
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The effectiveness of radial extracorporeal shock wave therapy (rESWT) in plantar fasciitis: a 12 months randomised controlled trial in a Tunisian rehabilitation department
CONCLUSION: Both protocols (rESWT and physiotherapy combined to ultrasound) were effective for improving morning pain at short term and midterm follow-up periods. Foot disorders should be initially evaluated and considered while treating.
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Enhanced external counter pulsation as a novel therapy to maintain cardiac output during hemodialysis: a preliminary randomized controlled study
Intradialytic cardiac output (CO) decline normally occurs during hemodialysis (HD) and results in short-term intradialytic hypotension to longer-term increased cardiovascular morbidity and mortality in chronic HD patients. Enhanced external counter pulsation (EECP) is a novel non-invasive device that has been demonstrated to improve coronary blood flow and maintain systemic hemodynamics in patients without kidney dysfunction.…
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Effect of prophylactic fibrinogen concentrate in scoliosis surgery (EFISS): a randomised pilot trial
CONCLUSIONS: This study demonstrates that the prophylactic administration of fibrinogen during scoliosis surgery in children is feasible and appears to be safe. Due to the limited sample size, no conclusions can be drawn regarding the efficacy of pre-emptive fibrinogen administration on clinical outcomes. However, the results provide valuable data to inform sample size calculation for…
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Cost analysis of integrating depression treatment into chronic care in Malawi: evidence from a cluster randomised controlled trial
CONCLUSIONS: These findings indicate that integrating depression care services into the Malawian health system is financially feasible and successfully reached many individuals with major depressive disorder.
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Dipsticks and point-of-care Microscopy in Urinary Tract Infections in primary care: Results of the MicUTI pilot cluster randomised controlled trial
CONCLUSION: The POCT-guided management approach for suspected uUTIs is feasible but presents implementation and methodological challenges. Recruitment varied across sites and was lower in the control group practices, highlighting the risk of differential recruitment. Retention was below the expected 80%, indicating the need for efficient follow-up strategies in future trials. Explorative analyses suggest that simply…
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Effect of a digital tool on breast cancer specific health-related quality of life and psychological distress: secondary results from the ADAPT study
CONCLUSION: The breast cancer digital tool did not have a significant effect on breast cancer-specific HRQoL and psychological distress over time. The results are consistent with the findings of the primary ADAPT paper, which demonstrated that the digital tool did not have a significant effect on patient activation, HRQoL, and health status. There is a…
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Efficacy of Stapled Haemorrhoidopexy vs. Ferguson Haemorrhoidectomy in the Treatment of Haemorrhoidal Disease: A Prospective, Randomised, Single-Blind Comparison
CONCLUSION: SH was equally effective as FH in controlling symptoms associated with HD in the postoperative period and may be recommended as a minimally invasive treatment option for patients.
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Can isokinetic muscle strength training with hip abduction and adduction improve muscle strength, balance, and gait in patients with functional ankle instability? A randomized controlled trial
CONCLUSIONS: Isokinetic strength training through the peri-ankle muscles combined with the hip adductor and abductor muscles was more effective than peri-ankle strength training alone in improving muscle strength, balance, plantar pressure, gait, and self-reported scores in FAI patients.
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Effect of caregiver training on knowledge and confidence of at-home clinical and anthropometric surveillance of children with uncomplicated severe acute malnutrition: analysis of a cross-over cluster randomised trial in Sokoto, Nigeria
INTRODUCTION: Patient-centred task-shifting models may be a promising strategy in the community-based management of severe acute malnutrition (SAM) to alleviate pressure on health systems and increase access to treatment in low-resource settings. The engagement of caregivers in clinical and anthropometric surveillance has not been evaluated.
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Are measures of voice hearing distinct from measures of emotional states, recovery and well-being? A factor analysis study
CONCLUSION: Findings show that measures of voice hearing are distinct from broad outcome measures and therefore are measuring separate concepts. This confirms the psychometric properties of the voice hearing measures and provides some clarity around outcomes and their measurement.