Clinical Trials
Category Added in a WPeMatico Campaign
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Effectiveness and Safety of Omidenepag Isopropyl 0.002% Ophthalmic Solution in Treatment-Naive Patients With Primary Open Angle Glaucoma: A Prospective Multicenter Phase IV Study
CONCLUSION: Omidenepag isopropyl 0.002% ophthalmic solution is suitable for first-line use at first diagnosis of POAG, including in patients with NTG.
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Community engagement in early childhood development intervention trials: lessons learnt from a stepping stones program in rural India
CONCLUSION: Structured, participatory community engagement was critical to the successful implementation and impact of the Stepping Stones Program. The program evolved from a top-down intervention to a community-driven platform for nurturing care. Findings support the utility of an adaptive engagement framework in building equitable, sustainable, and scalable ECD interventions in low-resource settings.
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Artificial intelligence-enhanced mapping of the international classification of functioning, disability and health via a mobile app: a randomized controlled trial
CONCLUSION: The MedQuest mobile application significantly improved workflow efficiency and demonstrated strong concordance between AI- and clinician-assigned ICF mappings. These findings support the feasibility of integrating AI-assisted tools into routine clinical documentation. A hybrid model, combining AI automation with clinician oversight, may enhance accuracy and reduce documentation burden in time-constrained healthcare environments.
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The efficacy of lactobacillus reuteri in conjunction with racecadotril in managing pediatric rotavirus enteritis and its impact on intestinal mucosa and immune function
CONCLUSIONS: Combining Lactobacillus reuteri and racecadotril in treating pediatric rotavirus enteritis demonstrated efficacy in regulating intestinal microbiota, alleviating mucosal barrier dysfunction, improving immune function, and enhancing treatment effectiveness.
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Reduced opioids after total joint replacement surgery (REPAIRS): a pilot randomized controlled trial
CONCLUSIONS: This pilot trial indicated that a full-scale trial would be feasible and acceptable. Such a trial could provide evidence of comparative effectiveness for the reduced opioid regimen in this population.
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Long COVID Optimal Health Programme to Enhance Mental and Physical Health: A Feasibility Randomised Controlled Trial
CONCLUSION: Findings support the feasibility of delivering the LC-OHP to people with LC. Further, initial data demonstrate potential for the programme to improve most outcomes at three and 6 months. Data from this feasibility trial will be used as an evidence base to support a fully powered RCT of the LC-OHP on patients with LC.
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Evaluating the effect of a smartphone-based self-help intervention on the quality of life of patients with acute coronary syndrome
CONCLUSION: The results of this study indicated that a smartphone-based self-help intervention effectively improved the quality of life of patients with ACS. Nurse managers and clinical nurses can utilize these findings to increase the quality of life of patients.
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Long-Term Outcomes After Fractional Flow Reserve vs Intravascular Ultrasound to Guide PCI: The FLAVOUR Trial Extended Follow-Up
CONCLUSIONS: FFR-guided and IVUS-guided treatment strategies resulted in comparable long-term outcomes, with no significant difference in patient-oriented composite outcomes. Although FFR-guided treatment was associated with a higher incidence of late target vessel revascularization, the overall target vessel PCI rate, accounting for both the index procedure and revascularization during follow-up, remained significantly lower in the FFR-guided…
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Statin Use in Patients With Advanced Prostate Cancer in the TITAN and SPARTAN Trials
CONCLUSIONS AND RELEVANCE: In this cohort study, statin exposure was associated with longer OS in patients treated with apalutamide. Statin-exposed patients had a higher risk of grade 3 or greater cardiac AEs, which may reflect their preexisting cardiovascular comorbidity.
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Dynamics of the EZ/RPE Loss Ratio on OCT Over Time During Geographic Atrophy Progression and Treatment With Pegcetacoplan
CONCLUSIONS: The change in EZ/RPE loss ratios at month 12 remained to be predictive for disease activity and therapeutic response, providing insights into disease mechanisms and relevant guidance for GA management in clinical practice. The EZ/RPE loss ratio decreased either due to advanced GA or induced by therapy in treated patients versus sham.