Clinical Trials
Category Added in a WPeMatico Campaign
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Cost-Effectiveness of Ultra-Early Tranexamic Acid as Add-On to Standard Care After Subarachnoid Hemorrhage (ULTRA Trial)
CONCLUSIONS: Ultra-early and short-term administration of TXA to patients with SAH is not cost-effective. Therefore, we recommend against using TXA for this patient group.
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Clinical Study of Hydromorphone Combined with Dexmedetomidine via Patient Controlled Analgesia for the Treatment of Acute Herpes Zoster Neuralgia
CONCLUSION: Hydromorphone combined with dexmedetomidine PCIA is effective in relieving HZ-related pain, and reducing the occurrence of postherpetic neuralgia (PHN). It shows a good therapeutic effect, a high safety profile, and an easy clinical application.
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Effects of docosahexaenoic acid supplementation on aggressive behavior among people with dementia: Secondary data analysis of a randomized clinical trial
We tested the efficacy of docosahexaenoic acid (DHA) supplementation on aggressive behavior among people with dementia. We used secondary data from a randomized, double-blind, placebo-controlled trial. Analyses included 402 individuals with dementia. We compared group differences in mean aggressive behavior change at baseline vs six (primary), 12, and 18 months (secondary outcome). We used independent…
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Peak Alpha Frequency Is Not Significantly Altered by Five Days of Experimental Pain and Repetitive Transcranial Stimulation of the Left Dorsolateral Prefrontal Cortex
Repetitive transcranial magnetic stimulation (rTMS) holds promise as a noninvasive pain treatment. Given the link between individual peak alpha frequency (PAF) of resting-state electroencephalographic recordings and pain sensitivity, and the potential for rTMS to modulate PAF, we investigated these relationships through a secondary analysis of established rTMS-induced analgesia in an experimental model of sustained muscle…
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Telerehabilitation versus face-to-face physical therapy for middle-aged patients with degenerative meniscal tear in China: a non-inferiority randomized controlled trial
CONCLUSION: Telerehabilitation was found to be clinically non-inferior to face-to-face physical therapy for improving knee function, pain, and quality of life in patients with degenerative meniscal tears. It offered significant cost savings, making it a cost-effective alternative to traditional in-person rehabilitation.
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Association of serum potassium time in target range with cardiovascular outcomes in patients with HFpEF
CONCLUSION: Maintaining sK levels within the range of 4.3-4.9 mmol/L most of the time in patients with HFpEF is associated with a lower risk of CV events or all-cause mortality.
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The effect of telerehabilitation on activity performance and participation in daily life in children with developmental coordination disorder: A randomized controlled trial
CONCLUSIONS: Telerehabilitation is an effective intervention for improving motor and cognitive functions, sensory processing, and daily life participation in children with DCD. The findings support the integration of telerehabilitation into sensory-based approaches as part of a holistic model of care in occupational therapy practice.
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The Effect of Breast Cancer Risk Reduction Program Applied to Women With High Breast Cancer Risk on Participation in Screening, Health Beliefs, and Behavior: A Randomized Controlled Trial
CONCLUSIONS: Breast Cancer Risk Reduction Program increased participation in screening in women and positively affected their health beliefs and behaviors.
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Metabolic Health and Heterogenous Outcomes of Prenatal Interventions: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this preplanned secondary analysis of a randomized clinical trial of an IBT on GWG among pregnant individuals, those with MUO experienced less GWG, had a higher incidence of gestational diabetes, and had infants with a higher proportion of adiposity compared with those who MHO. Data supported that the maternal obesity metabolic…
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Comparing the Costs of Surveillance of Early-Stage Breast Cancer by Digital or Traditional Follow-Up Methods: Randomized Crossover Study
CONCLUSIONS: We did not find any statistically significant differences in the total cost of follow-up of EBC by digital solution or phone calls. The number of visits and costs were higher during the latter follow-up period, probably due to the scheduled routine 1-year visit. There were more visits and higher costs in the digital solution…