Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of hydrotherapy kinetic chain exercises on muscle coactivation, pain management, and quality of life in men with chronic low back pain. Randomized clinical trial
CONCLUSION: The findings of this study underscore the importance of addressing the impaired coactivation of the transverse abdominal and multifidus muscles in men suffering from chronic non-specific low back pain. By implementing water kinetic chain exercises, we can effectively enhance muscle coactivation, which may lead to significant reductions in pain and improvements in overall quality…
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Acute effects of an aerobic dual task on processing speed and attention in Parkinson’s disease: a randomised controlled trial study
CONCLUSIONS: The DT developed on the MOTOmed cycling device is a safe intervention for people diagnosed with PD (stage 2-3) with or without mild or moderate cognitive impairment. This intervention, associated with a cognitive intervention, seems to show improvements in the speed of information processing.
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A composite endpoint for systemic sclerosis-associated interstitial lung disease: association with mortality in two clinical trial cohorts
CONCLUSION: The results of this post-hoc analysis provide further evidence that a composite endpoint comprised of physiological, radiological and patient-reported outcomes is a promising endpoint for SSc-ILD trials. Future validation studies are needed.
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Earmuff and eye mask in the treatment of acute primary headache in emergency department: a randomized controlled open label study
CONCLUSIONS: Earmuffs combined with sleep eye masks as an adjunct to metoclopramide significantly enhance early headache relief in the emergency department and represent a safe, low-cost complementary therapy. Participants were not blinded to the intervention due to practical constraints, and for the same reason, placebo control was not used.
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Novel syringe handle for one-handed anterior chamber paracentesis
CONCLUSIONS: We developed a novel syringe handle for one-handed AC paracentesis, which improved the safety and precision of the procedure while reducing procedural time. Its low-cost, reusable design and compatibility with standard syringes make it a practical tool for the procedure. Further clinical studies are warranted to explore broader applications.
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Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial
Melasma is a common hyperpigmentary skin disorder. Because of its high prevalence and serious complications, including negative psychiatric effects, early diagnosis and treatment would be essential. This randomized, double-blind, case-controlled clinical trial compared the efficacy of niosomal tranexamic acid (TXA) 2%/niacinamide (NCA) 2% cream and conventional TXA 5%/NCA 4% cream with topical hydroquinone (HQ) 4%…
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Prognostic impact of mitral regurgitation in elderly patients with atrial fibrillation: results from the CABANA trial
CONCLUSIONS: Among elderly patients with AF, msMR is associated with an increased risk of the primary composite endpoint of death, disabling stroke, serious bleeding or cardiac arrest.
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Efficacy and safety of a mosaic HIV-1 vaccine regimen in men who have sex with men and transgender individuals (HVTN 706/HPX3002/Mosaico): a global, randomised, double-blind, placebo-controlled, phase 3 trial
BACKGROUND: There is a high unmet need for effective HIV prevention options, including vaccines, for individuals at high risk of HIV acquisition who choose not to use pre-exposure prophylaxis or other prevention strategies. This study evaluated the efficacy and safety of an HIV-1 vaccine regimen consisting of tetravalent mosaic adenovirus serotype 26-based vaccine (Ad26.Mos4.HIV) and…
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Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT
CONCLUSIONS: Complement activation marker C3dg, MASP-1 and MASP-3 levels before TNFi therapy predicted new bone formation after 2 years of follow-up among axSpA patients with a high risk of radiographic progression. Furthermore, levels of L-ficolin and C3dg at follow-up were elevated in axSpA patients with new bone formation. Our findings support an association between activation…
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Enhancing Clinical Competencies Through Peer Role-Play in Oncology Graduate Students: Mixed Methods Study
CONCLUSIONS: This study indicates that peer role-play is an effective educational approach for developing clinical competencies in oncology graduate students, particularly in communication, empathy, and clinical reasoning. Role-play provides an engaging and practical learning experience, making it a valuable addition to clinical training programs aimed at enhancing patient-centered care skills in students.