Clinical Trials
Category Added in a WPeMatico Campaign
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Mindfulness-Based Stress Reduction Alleviates Depression, Anxiety, and Internalized Stigma Compared With Treatment-as-Usual Among Head and Neck Cancer Patients: Findings From a Randomized Controlled Trial
Background: This study aimed to: (1) compare the rates of change in the severity of depression and anxiety symptoms (primary outcomes) as well as internalized stigma and its components (shame with appearance [SWA], speech and social concerns [SSCs], sense of stigma [SS], and regret [R]; secondary outcomes) between the mindfulness-based stress reduction (MBSR) group and…
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Rosuvastatin for Improving Fetal Growth Restriction in Pregnant Women: A Double-Blind Randomized Clinical Trial
CONCLUSION: Rosuvastatin demonstrated improved perinatal outcomes in FGR pregnancies without adverse neonatal effects.Trial Registration Number: IRCT20140317017035N8.
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tDCS and Speech Therapy in Aphasia Treatment: A Multicenter Comparative Study of Efficacy
BACKGROUND Aphasia is a common consequence of stroke and traumatic brain injury (TBI) that significantly impairs communication and quality of life. Transcranial direct current stimulation (tDCS) has emerged as a non-invasive technique potentially enhancing language rehabilitation. This study aimed to evaluate the efficacy of tDCS in combination with speech-language therapy (SLT) in improving language functions…
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Impact of patisiran on polyneuropathy of hereditary transthyretin amyloidosis in patients with a V122I or T60A variant: a phase IV multicenter study
CONCLUSIONS: Patisiran demonstrated a consistent positive effect across multiple endpoints in patients with V122I/T60A ATTRv amyloidosis, including polyneuropathy manifestations.
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Effectiveness of photobiomodulation therapy as an adjunct to surface spinal stimulation and activity-based therapy in compressive cervical myelopathy: a parallel group, non-blinded randomized controlled trial
To reverse the progression of compressive cervical myelopathy (CCM) by repairing injured nerve tissue, improving sensory integration, balance, disability, and quality of life (QoL) with Photobiomodulation Therapy (PBMT) as an adjunct to Surface Spinal Stimulation (SSS) and Activity-Based Therapy (ABT). Thirty-two individuals in the age group between, 20 and 65 years diagnosed with sub-acute CCM…
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Impact of an interdisciplinary digital consultation platform on general practitioner referrals for musculoskeletal symptoms: a stepped wedge cluster randomized trial
CONCLUSIONS: We observed a modest increase in appropriate referrals for orthopaedic review among GP practices randomized to the platform. On a larger scale, this could contribute to more sustainable access to specialist care.
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High-intensity exercise improves multidimensional fatigue and health-related quality of life in rheumatoid arthritis: a randomized controlled study
CONCLUSIONS: The high-intensity exercise intervention had a beneficial effect on multidimensional fatigue, and health-related quality of life in people with RA. The effect on fatigue and health-related quality of life persisted during the 12 months-follow up period indicating long-term effects.
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Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial
CONCLUSION: Cocoa extract supplementation significantly decreased hsCRP, supporting a role in modulating the chronic inflammaging process as a potential mechanism underlying its cardio-protective effects, including a 27% reduction in cardiovascular disease death in the COSMOS trial. The biological effect of increased IFN-γ by cocoa extract warrants further exploration.
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Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial
CONCLUSION: Aerobic-resistance exercise combined with sequential computerised cognitive training improved gait performance at 6 months and decreased the risk of falls and injuries at 12 months in older adults with MCI. The addition of vitamin D did not produce benefits.
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Effectiveness of Smartwatch Device on Adherence to Home-Based Cardiac Rehabilitation in Patients With Coronary Heart Disease: Randomized Controlled Trial
CONCLUSIONS: This study demonstrates that a smartwatch-facilitated HBCR model is both feasible and effective in enhancing adherence and improving clinical outcomes among patients with CHD. These findings support the integration of wearable technology into routine HBCR and lay the groundwork for future large-scale, multicenter trials.