Clinical Trials
Category Added in a WPeMatico Campaign
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Health Services and Economic Impacts of the Limit of Detection in Emergency Department (LEGEND) Rule-Out Strategy in Australian Emergency Departments: A Stepped-Wedge Cluster Randomised Trial
CONCLUSIONS: The LEGEND strategy demonstrated reduced resource utilisation and costs compared to guideline-based ACS assessment, particularly for low-risk patients. Widespread adoption could improve the efficiency and cost-effectiveness of ACS assessment in the healthcare system.
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The effects of communicating illness diagnostic and treatment information and C-reactive protein test results on people’s antibiotic expectations
CONCLUSIONS: Simple, evidence-based communication strategies-particularly when combined with diagnostic test results-can reduce antibiotic expectations, offering practical tools for clinicians to support appropriate prescribing.
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Economic evaluation of financial incentives for maternal and child health in the Democratic Republic of the Congo (DRC): a decision-tree modelling based on a cluster randomized controlled trial
CONCLUSIONS: Using three times the gross domestic product per capita in 2021 (US$1,732) as the threshold, the PBF program is a cost-effective strategy, though with substantial variation. It is crucial to take action to maintain gains from the improved MCH coverage resulting from the PBF program.
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Coronary flow reserve increase after 4-year dapagliflozin treatment in patients with type 2 diabetes: the DAPAHEART follow-up study
CONCLUSION: The 30% CFR improvement seen after 4 weeks of dapagliflozin persisted at 4 years, together with a significant reduction in EAT thickness, possibly explaining CFR improvement. Similar results in the placebo group after treatment strongly support a causal relationship and underscore the long-term CV benefits of dapagliflozin and its role in reducing CV risk…
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Weight-independent amelioration of adipokine profile by enavogliflozin, a selective SGLT2 inhibitor, in patients with type 2 diabetes
CONCLUSIONS: Enavogliflozin treatment decreased leptin over 24 weeks in patients with type 2 diabetes, and this effect remained significant after adjusting for weight change, suggesting an improved adipokine profile. Reductions in leptin were also associated with improvements in insulin resistance and increases in serum ketone levels. These results highlight enavogliflozin as a potential treatment beyond…
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Linear correlation between white blood cell counts and the progression and prognosis of acute kidney injury
IntroductionWhite blood cell count, a cost-effective blood test marker, is used extensively for the diagnosis and prognosis of diseases. Nevertheless, its association with the progression and prognosis of acute kidney injury remains unclear.MethodsA retrospective analysis was conducted using data from a multicenter randomized trial on an acute kidney injury early warning system. Univariate analysis, multivariate…
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THE IMPACT OF HYALURONIC ACID ON GINGIVITIS AND PERIODONTAL HEALTH
Gingivitis is a reversible inflammatory condition of the gingival tissues, primarily initiated by microbial plaque accumulation. The present study aimed to assess the therapeutic efficacy of 1% hyaluronic acid (HA) gel as an adjuvant remedy to standard scaling and polishing procedures (SPP) in the management of gingivitis. Twenty systemically healthy adults diagnosed with gingivitis were…
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The high-dose dual therapy for eradication of Helicobacter pylori: efficacy and safety
CONCLUSION: The efficacy of the Era-RebAmIPP regimen is comparable to conventional triple therapy with bismuth. To assess the effectiveness of this regimen, larger-scale studies are required in various regions of our country.
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Study on the efficacy of combination therapy with rifaximin and Saccharomyces boulardii CNCM I-745 in patients with small intestinal bacterial overgrowth associated with long-term use of proton pump inhibitors
CONCLUSION: This prospective comparative study demonstrates that combination therapy with rifaximin and Saccharomyces boulardii CNCM I-745 appears more effective than rifaximin monotherapy for SIBO eradication, symptom regression, and QoL improvement in patients with PPI-associated SIBO.
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Return to normal activity after abdominal surgery: a pre-planned secondary analysis of a randomised controlled trial across seven low- and middle-income countries
CONCLUSIONS: With rising need for surgical care and non-communicable disease globally, this study highlights the groups of patients at critical need for improving return to normal activity or recovery after surgery in LMICs. Improving access and implementation of rehabilitation pathways, aligned to the World Health Organisation, may be crucial to improve financial risk protection to…