Clinical Trials
Category Added in a WPeMatico Campaign
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Abdominal massage as an adjunctive therapy for pediatric functional constipation: a randomized controlled trial
CONCLUSION: A 12-session abdominal massage therapy program appears to be an effective adjunct treatment to standard pharmacological therapy for alleviating constipation-related symptoms in children. Larger, multicenter trials are needed to confirm these findings.
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Comparative evaluation of safety and efficacy of dapoxetine, silodosin, and citalopram in the management of premature ejaculation: a randomized clinical trial
CONCLUSION: In this direct head-to-head comparison of active treatments for lifelong PE, daily citalopram (20 mg) demonstrated superior efficacy in prolonging IELT and improving psychosocial outcomes compared to daily or on-demand dapoxetine and silodosin. The findings suggest that citalopram is a highly effective first-line option, while the dose-dependent efficacy of dapoxetine and the distinct side-effect…
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Hospital-Level Care at Home for Adults Living in Rural Settings: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of home hospital care in rural settings, cost and readmission were unchanged while patient activity and experience improved. Late transfer home likely attenuated the intervention’s effect.
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Magnetic seed versus guidewire-based breast cancer localization with magnetic lymph node detection: cost-minimization analysis
CONCLUSION: In this predefined health economic analysis of an RCT, the use of magnetic seeds resulted in incremental cost containment, despite the increased cost of the device. Contributing factors included shorter localization time, shorter operating time, and process streamlining.
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Impacts of Experimental Knee Pain on Gait Biomechanics and Pain Sensitivity: A Randomised Crossover Trial of Young and Pain-Free Volunteers
CONCLUSION: Changes in PPTs and propulsion impulse were observed after the knee pain induction. Peak knee pain variability can be partly explained using a combination of biomechanics, pain sensitivity and cognitive factors. This forms the basis for a targeted clinical evaluation of patients.
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The effect of posture and breathing exercises applied with telerehabilitation on respiratory functions, exercise capacity, fatigue, and psychosocial factors in chronic obstructive pulmonary disease patients
CONCLUSION: It was concluded that exercise with telerehabilitation in COPD patients is effective on quality of life, exercise capacity, fatigue, psychosocial factors and can be used as a treatment approach.
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Effect of flywheel resistance training on sleep quality in older women: A randomized controlled trial
CONCLUSION: Eight weeks of intervention did not affect objective sleep measures but improved subjective sleep quality, particularly in the FRT group.
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Effectiveness of movement system impairment (MSI) based classification treatment on clinical outcomes among subjects with tibiofemoral hypomobility syndrome: A randomized controlled trial
CONCLUSION: The MSI treatment model effectively treats subjects with tibiofemoral hypomobility syndrome and shows greater improvement than standard physical therapy care. These findings suggest that MSI-based treatment can contribute to global health efforts to minimize musculoskeletal conditions. Further studies to bring long-term follow-up and other physical performance outcomes.
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Evaluation of thiol-disulfide homeostasis under low and standard pneumoperitoneum in elderly patients undergoing laparoscopic cholecystectomy: a prospective comparative study
CONCLUSION: While higher intra-abdominal pressure may be associated with mild hepatic stress, it does not appear to cause significant oxidative imbalance in geriatric patients. Both low and high-pressure pneumoperitoneum levels can be used safely during laparoscopic cholecystectomy in elderly individuals, provided that appropriate perioperative management is ensured.
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Effects of hydrotherapy kinetic chain exercises on muscle coactivation, pain management, and quality of life in men with chronic low back pain. Randomized clinical trial
CONCLUSION: The findings of this study underscore the importance of addressing the impaired coactivation of the transverse abdominal and multifidus muscles in men suffering from chronic non-specific low back pain. By implementing water kinetic chain exercises, we can effectively enhance muscle coactivation, which may lead to significant reductions in pain and improvements in overall quality…