Clinical Trials
Category Added in a WPeMatico Campaign
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A randomised controlled trial to assess the feasibility and acceptability of remote psychosocial and exercise interventions for people with lupus: The ADAPT feasibility trial
Limited psychosocial support is available for people with lupus despite the highly reduced quality of life. This study assessed the acceptability, feasibility, and effectiveness estimations, of three (two psychosocial, one exercise) interventions. Lupus patients (N = 124) were randomised to a control arm or one of three interventions delivered remotely over 8-12 weeks: (1) listening…
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Multimodal prognostic modeling of individual cognitive trajectories to enhance trial efficiency in preclinical Alzheimer’s disease
INTRODUCTION: Cognitive decline in asymptomatic preclinical Alzheimer’s disease (AD) is slow and variable, limiting detection of treatment effects. This study developed models to forecast trajectories and improve trial efficiency.
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Eribulin plus Pyrotinib in Trastuzumab-Resistant, HER2-Positive Advanced Breast Cancer: A Single-Arm, Multicenter Phase II Trial (EPIC Trial)
CONCLUSION: The combination of Eribulin and Pyrotinib emerges as a viable treatment option for HER2-positive advanced breast cancer patients who have exhibited resistance to trastuzumab. Despite advancements in anti-HER2 therapies, further research is required to address remaining challenges in this specific clinical scenario.
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Culturally adapted hypocaloric diet improves hepatic steatosis, inflammatory and oxidative biomarkers in Egyptian MASLD patients: a single-arm interventional study
CONCLUSION: A culturally tailored hypocaloric diet effectively improved hepatic steatosis, inflammatory status, and antioxidant capacity in Egyptian MASLD patients. These improvements were partially weight-independent and partially mediated by anti-inflammatory responses. These findings support hypocaloric dietary strategies as a potentially scalable therapeutic option for MASLD management in resource-limited settings, though the absence of a control group…
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Validating the Efficacy of a Mobile Digital Therapeutic for Insomnia (WELT-I): Randomized Controlled Decentralized Clinical Trial
CONCLUSIONS: WELT-I showed significant therapeutic efficacy and safety in improving sleep efficiency and sleep-related dysfunctional attitudes in cases of insomnia. In addition, this study demonstrated the feasibility of DCTs, and the findings of rapid recruitment, high compliance and retention rates, and strong participant satisfaction suggest that DCTs have sufficient potential to be expanded to clinical…
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A New Progressive Motor-Control-Based Exercise Approach for Women with Diastasis Recti Abdominis: The Denizoglu Method
CONCLUSIONS: The Denizoglu Method emerges as a promising approach for managing DRA in clinical practice. It can be effectively implemented as a supervised home-based exercise program or integrated in women’s health care centers during the 1 to 3 years postpartum period.
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Effects of cognitive rehabilitation and exercise on brain structure in progressive multiple sclerosis: results from the CogEx trial
CONCLUSIONS: Our analysis showed a decrease in brain volumes and limited effects of the combined CR + EX intervention, indicating that the previously found cortical GM increase was not superimposable at voxel level. Methodological and sampling differences between the studies could explain these discrepancies. In few cognitively relevant areas, the combined CR interventions might have…
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Cosmetic and Application Qualities of the Cream Physiorelax Compared to Another Topical Cream for Musculoskeletal Health Care: An Organoleptic Expert Panel Approach
CONCLUSION: Considering the panelists’ general preference for Physiorelax, and the addition in this product of extra natural ingredients preserving skin care, Physiorelax seems a very good candidate for daily use for musculoskeletal health care and as a massage cream for muscles and ligaments in personal care.
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Preventive Efficacy of Oxygenation on Contrast-Associated Acute Kidney Injury in Chronic Kidney Disease (stages 3-5) Patients Undergoing Elective Coronary Angiography Revascularisation: An Open Label Bicentric Randomised Controlled Trial
CONCLUSION: Oxygen supplementation and saline hydration effectively prevented CA-AKI in CKD stages 3-5 patients undergoing elective CAG ± R. Hence, oxygen therapy should be a standard CA-AKI protective strategy during CAG ± R and radiocontrast-related procedures.
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Mindfulness-Based Stress Reduction Alleviates Depression, Anxiety, and Internalized Stigma Compared With Treatment-as-Usual Among Head and Neck Cancer Patients: Findings From a Randomized Controlled Trial
Background: This study aimed to: (1) compare the rates of change in the severity of depression and anxiety symptoms (primary outcomes) as well as internalized stigma and its components (shame with appearance [SWA], speech and social concerns [SSCs], sense of stigma [SS], and regret [R]; secondary outcomes) between the mindfulness-based stress reduction (MBSR) group and…