Clinical Trials
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Behavioral and electrophysiological evidence of reward processing deficits in repetitive negative thinking: Implications for depression
CONCLUSIONS: RNT may transiently disrupt behavioral and neural indicators of reward functioning. These findings suggest that cognitive states such as RNT can exacerbate or reveal the latent reward-processing deficits typically observed in individuals with anhedonia. This state-dependent sensitivity highlights the potential utility of targeting RNT to restore reward processing in depression.
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White light imaging versus artificial intelligence-assisted white light imaging for colorectal neoplasia detection: a randomised trial
CONCLUSIONS: AI-assisted colonoscopy demonstrated high ADR and NDR. While without statistical relevance overall, marginal significance was observed for screening patients.
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Effects of Artificial Intelligence Recognition-Based Telerehabilitation on Exercise Capacity in Patients With Hypertension: Randomized Controlled Trial
CONCLUSIONS: Compared with conventional exercise rehabilitation, AI-assisted remote rehabilitation was found to improve exercise capacity, boost regular physical activity and exercise self-efficacy, and aid in systolic BP control among patients with hypertension. This study positioned AI-assisted rehabilitation as a scalable and effective strategy for real-world hypertension management. It further contributes actionable guidance for developing effective…
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Evaluation of safety and efficacy of the combination of mebeverine and sulpiride in treatment of patients with functional gastrointestinal disorders: A prospective cohort
ObjectiveIn this study, we aimed to evaluate the safety and efficacy of a combination of 100 mg mebeverine and 25 mg sulpiride (Colona®) in patients with functional gastrointestinal disorders.MethodsThis multicenter, cohort study was conducted in Egypt, comprising 253 patients diagnosed with functional gastrointestinal disorders. The treatment duration was 2 weeks. The primary endpoint was the…
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Therapeutical efficacy of immunobiotics in patients with newly diagnosed rheumatoid arthritis
CONCLUSIONS: Adjunctive probiotic supplementation with specific strains may enhance clinical outcomes, reduce inflammation, and increase remission rates in early RA, supporting probiotics as a safe, accessible adjunctive therapy.
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Impact of secukinumab with modified nourishing blood and moisturising decoction on superficial fungal infections in patients with psoriasis with blood-dryness pattern
CONCLUSION: In this study, combining secukinumab with a modified nourishing and moisturising TCM regimen yielded superior clinical outcomes, including greater symptom relief, improved quality of life, and a reduced risk of superficial fungal infections compared with biologic monotherapy.
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A BOPPPS-based micro-lecture teaching intervention for orthopaedic postgraduates in China
BACKGROUND: Orthopaedics is a highly specialized discipline characterized by complex theoretical frameworks and extensive knowledge, posing challenges for postgraduate teaching. With the advancement of educational technology, micro-lectures have been increasingly adopted in medical education. However, their isolated use may be insufficient to sustain student engagement or ensure effective learning. The bridge-in, learning objective, pre-test, participatory…
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Early essential newborn care for late preterm and term infants delivered by cesarean section: a randomized controlled trial on neonatal hypoglycemia and breastfeeding
CONCLUSION: The EENC improves neonatal glucose regulation and breastfeeding in cesarean-born late preterm and term infants, potentially enhancing neonatal health, maternal-infant bonding, and postpartum transition.
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Feasibility trial of a transdiagnostic individual lifestyle evaluation and intervention (Lev-i) for health behavior change
CONCLUSION: Findings suggest that Lev-i is a feasible and acceptable intervention for promoting health behaviors among individuals with disabilities. However, further refinements may enhance feasibility for both patients and professionals before conducting a randomized controlled trial. ClinicalTrials.gov (NCT05889936).
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Interobserver agreement for the assessment of erosive reflux esophagitis: a post hoc analysis of clinical trial data
Interobserver agreement for the Los Angeles (LA) classification of erosive reflux esophagitis was good in validation studies, but limited agreement data exists from clinical trials (CTs). We conducted a post hoc evaluation of interobserver agreement between CT endoscopists and independent expert adjudicators in a multi-center, randomized controlled trial of a new acid suppression therapy. Trial…