Clinical Trials
Category Added in a WPeMatico Campaign
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Functional Connectivity Predicting Transdiagnostic Treatment Outcomes in Internalizing Psychopathologies
CONCLUSIONS AND RELEVANCE: In this prognostic study assessing predictive models of 181 patients with IPs, whole-brain FC reliably predicted multidimensional treatment outcomes across diagnoses and treatment modalities. These results suggest an association between neural connectivity patterns within specific neural networks and clinical improvements induced by varying treatment modalities, thereby advancing efforts toward personalized treatment approaches…
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Evaluation of the therapeutic effects of Er:YAG laser with different parameters on peri-implantitis
This study evaluates the therapeutic effects of erbium-doped yttrium aluminum garnet (Er:YAG) laser treatment at different energy settings on peri-implantitis in a randomized clinical setting. Forty patients diagnosed with permanent molar fissure caries were randomly assigned to 5 treatment groups, each receiving a distinct treatment protocol. The effectiveness of these interventions was evaluated by comparing…
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The effect of psychological intervention combined with standard pharmacological therapy in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): A randomized controlled trial
CONCLUSION: The combination of PI and conventional antibiotics is effective for CP/CPPS patients with longer disease course and more severe symptoms. Early PI is recommended to achieve better therapeutic results.
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Evaluation of the effects of delayed cord clamping in neonates with intrauterine growth restriction
To assess the effects of delayed cord clamping (DCC) at birth on newborns diagnosed with intrauterine growth restriction (IUGR). This prospective, randomized, controlled study included newborns diagnosed with IUGR during pregnancy follow-up and born at a gestational age of ≥28 weeks. Early cord clamping (ECC) was performed immediately after birth, whereas DCC was performed 60…
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Behavioral Economic Framing for Enrollment and Retention of Patients in Remote Blood Pressure Monitoring: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the behavioral economic approach of opt-out framing vs opt-in framing did not improve enrollment and retention of patients in a remote BP monitoring program. The findings suggest additional approaches are needed to boost participation.
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Measurement-Based Care to Enhance Antidepressant Treatment Outcomes in Major Depressive Disorder: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This trial of adults with MDD found that MBC led to faster time to response and time to remission than standard care in low-resource settings. Future studies need to confirm the clinical effectiveness of MBC and assess its cost-effectiveness in LMICs.
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High-power Ho:YAG lithotripsy increases subclinical renal stress: a prospective randomized KIM-1 study
This study aimed to compare the safety profile of high-power (HPL) and low-power (LPL) Holmium:YAG lasers in retrograde intrarenal surgery (RIRS), using urinary Kidney Injury Molecule-1 (KIM-1) as an early biomarker for acute kidney injury (AKI). Sixty patients with renal stones (1.5-2.5 cm) were prospectively randomized into HPL and LPL groups. Urinary KIM-1 and KIM-1/creatinine…
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Jueling Mingmu decoction combined with ranibizumab for retinal vein occlusion induced macular edema: A randomized controlled clinical trial
CONCLUSION: The combination of Jueling Mingmu Decoction and ranibizumab appears to be a potentially effective treatment for improving visual and anatomical outcomes in RVO-related ME, especially in BRVO patients. However, it does not significantly reduce the number of required intravitreal injections compared to monotherapy. Further studies are needed to confirm these findings and explore the…
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High-intensity Interval Training and Mindfulness Breathing Induce Hormonal, Metabolic, and Anticarcinogenic Effects in Obese Postmenopausal Women: A Randomized Controlled Trial
ObjectiveTo find out the effect of high-intensity interval training (HIIT) and mindfulness breathing on the levels of sex hormones, insulin resistance, lipid profiles, and tumor biomarkers in postmenopausal obese women.DesignSeventy obese postmenopausal women (aged 55-65 years, with a body mass index (BMI) ranging from 35-44.9 kg/m²) were allocated into two groups for this prospective, randomized,…
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Effect of cotton roll biting on pain perception during orthodontic bracket debonding using Weingart pliers: A randomized controlled trial
ObjectiveThis study aimed to evaluate the effectiveness of biting on a cotton roll in reducing pain during metal bracket removal using a Weingart plier compared with the conventional method.MethodsThis two-arm, parallel-group, randomized controlled trial included 36 patients (11 males and 25 females) with a mean age of 20.5 ± 3.08 years (range: 16-25 years). The…