Clinical Trials
Category Added in a WPeMatico Campaign
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An Open-Label, Single-Arm, Phase II Trial of Sintilimab Plus Anlotinib for Metastatic Non-Small Cell Lung Cancer After First-Line PD-(L)1 Inhibitor
CONCLUSION: Sintilimab combined with anlotinib exhibited favorable antitumor activity and tolerable toxicity in post-anti-PD-(L)1 therapy of metastatic NSCLC patients, supporting further randomized controlled trials.
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De-escalated adjuvant radiotherapy versus standard adjuvant treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma (MC1675): a phase 3, open-label, randomised controlled trial
BACKGROUND: Standard adjuvant chemoradiotherapy (60-66 Gy) following surgery for HPV-associated oropharyngeal squamous cell carcinoma has excellent oncological control but high treatment morbidity. We aimed to compare toxicity of a 30-36 Gy regimen of de-escalated adjuvant radiotherapy and standard of care treatment.
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The Effect of a Psychodrama-Based Group Intervention on Anger and Self-Injurious Behaviors in Adolescents Diagnosed with Substance Use Disorder: A Randomized Controlled Trial
CONCLUSION: Psychodrama group work significantly reduced anger and self-injury behaviors in adolescents with substance use disorders. Integrating psychodrama into treatment is recommended to improve care outcomes.
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Effects of s-ketamine and midazolam on respiratory variability: A randomized controlled pilot trial
S-ketamine and midazolam are frequently used to provide sedation while maintaining spontaneous respiration. However, the effects of these agents on respiratory variability, which reflects the adaptability of the respiratory system, have not been thoroughly explored. We evaluated these effects in a randomized controlled pilot trial. This study was conducted as part of a randomized controlled…
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Blunted anterior midcingulate response to reward in opioid users is normalized by prefrontal transcranial magnetic stimulation
Abnormalities in goal-directed behavior, mediated by mesocorticolimbic reward system, contribute to worse clinical outcomes including higher risk of treatment dropout and drug relapse in opioid users (OU). Despite efforts to counteract such neural alterations, brain-based interventions for this disorder remain ineffective. In this sham-controlled randomized study, we report the initial results on the efficacy of…
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Early childhood caries intervention in Aboriginal Australian children: Follow-up at child age 9 years
CONCLUSION: The present study suggests that, within this cohort, initiating an early childhood caries intervention during pregnancy and infancy may be associated with lower caries experience in the primary dentition by age 9 years compared to a later start. Low maternal education level was associated with caries severity in both primary and permanent dentitions. Sugar…
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Efficacy of N-acetylcysteine vs dexamethasone in preventing postembolization syndrome post-transarterial chemoembolization in hepatocellular carcinoma: A randomized controlled trial
CONCLUSION: Compared with DEXA, NAC significantly reduces the incidence of PES, regardless of its impact on liver function recovery. Therefore, NAC is a preferable option for reducing PES in Barcelona Clinic Liver Cancer-B stage HCC patients with preserved liver function.
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Efficacy of a Multimodal Ayurveda Regimen in the Management of Primary Knee Osteoarthritis: Protocol for an Open-Label Randomized Controlled Trial
CONCLUSIONS: This randomized controlled trial will be the first study to explore the potential benefits of a multimodal Ayurveda regimen (based on Ayurveda principles and scientific evidence) in the long-term management of osteoarthritis of the knee through validated subjective, laboratory, and imaging parameters. The outcomes of this study may address the needs and challenges associated…
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AI-driven early detection of severe influenza in Jiangsu, China: a deep learning model validated through the design of multi-center clinical trials and prospective real-world deployment
BACKGROUND: Influenza-related global deaths reach 650,000 annually. The current highly lethal clinical subtype of influenza is severe influenza.
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A prospective controlled study on degenerative lumbar spondylolisthesis treated with three steps and nine methods combined with physiotherapy
CONCLUSION: The Three-Step Nine-Method Lumbar Correction combined with physical therapy has a definite efficacy in the treatment of DLS. It can significantly relieve pain symptoms, improve physical function and patients’ quality of life. Its effect is better than that of pelvic traction combined with physical therapy, and it has high safety. However, its improvement on…