Clinical Trials
Category Added in a WPeMatico Campaign
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Enhanced Eustachian Tube Function and Hearing Recovery with Combined Balloon Dilatation and Tympanic Membrane Catheterization in Secretory Otitis Media
BACKGROUND Secretory otitis media (SOM), a common otorhinolaryngological disorder, impairs hearing and quality of life. Eustachian tube balloon dilatation (ETBD) is increasingly used, and its combination with tympanic membrane catheterization (TMC) may enhance outcomes. This study compared ETBD alone with ETBD combined with TMC in adult SOM. MATERIAL AND METHODS Ninety patients (110 ears) with…
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A Phase II Pilot Study of Anti-PD-L1, Durvalumab, and a PARP Inhibitor, Olaparib in Patients With Metastatic Triple-Negative Breast Cancer With or Without Germline BRCA Mutation
CONCLUSION: Our study demonstrated modest clinical benefits of D + O with ORR of 28.6% in subsets of heavily pretreated TNBC. Further detailed classification of DCs to understand the predictive role of DCs and prospective validation in a large cohort is required.
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Virtual Standardized Patients for Improving Clinical Thinking Ability Training in Residents: Randomized Controlled Trial
CONCLUSIONS: VSPs reinforce the foundational knowledge of internal medicine among medical students and enhance their clinical thinking abilities, as well as improve their capacity for independent work. The VSP system is feasible, practical, and cost-effective, making it worthy of further promotion in clinical education.
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Compression Hosiery to Avoid the Post-Thrombotic Syndrome: a synopsis of the CHAPS RCT
CONCLUSIONS: The sample size was not reached, which precluded any formal statistical analysis. Although a difference in the incidence of post-thrombotic syndrome was demonstrated, the effect size could not be determined. There is interest in understanding optimal strategies for the prevention of post-thrombotic syndrome in these patients and a re-run of this trial should occur.
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Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With Alzheimer Disease: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, home-based gamma tACS was feasible and improved clinical outcomes in AD, with neurophysiological evidence of brain engagement. These findings support further investigation of gamma tACS as a potential therapeutic intervention for AD.
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Influence of an internet-based proactive follow-up management model on the prognosis of nonalcoholic fatty liver disease
CONCLUSION: The internet-based proactive follow-up management model can provide personalized health management plans and reduce the risk of disease deterioration, making it worthy of promotion in a broader healthcare context.
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Roasting oat-based paste modulates postprandial glucose and insulin sensitivity: Roles of acrylamide, texture, and starch fractions
Oat-based foods are widely recommended for dysphagia management and glycemic control, yet the impact of roasting conditions on their health benefits remains unclear. This study compared the postprandial glycemic and insulinemic responses to oat pastes prepared from low-temperature (90-110 °C) and conventional high-temperature (160 °C) roasted oat flours, using refined rice (R) as a reference,…
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Efficacy and safety of PD-L1 blockade envafolimab as neoadjuvant treatment in mismatch repair-deficient, locally advanced colorectal cancer: An open-label, single-arm study
CONCLUSIONS: This preliminary study suggests that envafolimab is a promising effective and safe neoadjuvant option for locally advanced dMMR CRC; confirmation in larger cohorts is awaited.
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Effects of finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)
CONCLUSIONS: Finerenone did not affect changes in vascular stiffness but led to a significant and sustained reduction in albuminuria in patients with T2D and CKD. The clinical benefits of finerenone may result from lowering intraglomerular pressure rather than from its effect on vascular stiffness.
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Cost-effectiveness of a single-layer high compression bandage versus Unna’s boot for venous leg ulcer treatment: the VENOS trial
CONCLUSION: In this study, SLHCB was cost-effective when compared with UB. These findings may prompt decision-makers to weigh the prospect of allocating an additional R$1.07 (I$0.42) for each percentage point reduction in VLU area or R$1739.13 (I$687.40) per QALY gained. This financial consideration holds significant implications for guiding resource allocation.