Clinical Trials
Category Added in a WPeMatico Campaign
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Improved Etiological Diagnosis of Nonresolving or Slowly Resolving Pneumonia Through Combined Endobronchial Ultrasound-Guided Biopsy and Metagenomic Sequencing
Background: Nonresolving or slowly resolving pneumonia (NRP) poses a diagnostic challenge because infectious and noninfectious etiologies often mimic community-acquired pneumonia on imaging. Endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) improves tissue acquisition for peripheral lesions, whereas metagenomic next-generation sequencing (mNGS) offers culture-independent pathogen detection. Whether their combination enhances etiological clarification of NRP remains…
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Effect of Focused Ultrasound With or Without Anti-HPV beta-Glucan Therapy on Persistent Cervical HPV Infection: A Randomized Controlled Trial
Persistent high-risk human papillomavirus (HPV) infection is a leading cause of cervical cancer worldwide. While prophylactic vaccines exist, many women remain at risk due to prior exposure or limited access to vaccination. Current treatments focus on ablating visible lesions but often fail to clear the virus completely. Adjunctive therapies that enhance immune clearance may improve…
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Safety of artificial intelligence-assisted optical diagnosis for leaving colorectal polyps in situ during colonoscopy (PRACTICE): a non-inferiority, randomised controlled trial
BACKGROUND: Guidelines recommend leaving in situ rectosigmoid polyps diagnosed during colonoscopy that are 5 mm or smaller if the endoscopist optically predicts them to be non-neoplastic. However, no randomised controlled trial has been done to examine the efficacy and safety of this strategy.
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Healthcare Expenditures Associated With Implementing an External Facilitation Program to Increase the Prescribing of Medications Used for the Treatment of Opioid Use Disorder Among Veterans
CONCLUSIONS: Veterans at intervention sites with an OUD history had higher outpatient psychiatric-related costs, which could be explained by increased access to optimal mental health services at VHA. Improving access to OUD treatment at VA may lead to more coordinated and comprehensive treatment of both OUD and other associated mental health and physical comorbidities.
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Risk factors and leprosy incidence among contacts in Bangladesh: A multilevel analysis
CONCLUSIONS AND RECOMMENDATIONS: BCG vaccination of contacts is effective in preventing leprosy, overall there is no clear benefit of adding SDR after BCG to reduce the number of excess leprosy cases after vaccination. SDR after BCG, however, appears effective to prevent leprosy in contacts of MB patients, smear positive index patients, and second degree blood-related…
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Effects of Focused Solution Model Nursing on quality of life and negative emotions of prostate cancer patients
CONCLUSION: Focused Solution Model Nursing intervention can effectively improve the quality of life and negative emotions of the prostate cancer patients in the clinical treatment.
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Clinical research of Zhuangdan Yanshi Decoction combined with dapoxetine hydrochloride in the treatment of premature ejaculation with cholestasis and phlegm disturbance syndrome
CONCLUSION: The combination therapy with Zhuangdan Yanshi Decoction and dapoxetine hydrochloride for premature ejaculation associated with cholestasis and phlegm disturbance syndrome is definite, and it can reduce the side effects of drugs, which is better than oral dapoxetine hydrochloride alone.
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Rapid Brain Adaptation to Hearing Amplification: A Randomized Crossover Trial of Personal Sound Amplification Products
Understanding speech in noise is a common challenge for older adults, often requiring increased listening effort that can deplete cognitive resources and impair higher-order functions. Hearing aids are the gold standard intervention for hearing loss, but cost and accessibility barriers have driven interest in alternatives such as Personal Sound Amplification Products (PSAPs). While PSAPs are…
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Insights Into How Digital Health Interventions Shape Outcomes for Emerging Adults Living With Type 1 Diabetes: Qualitative Realist Process Evaluation
CONCLUSIONS: A multicomponent, text message-based digital intervention could support emerging adults living with T1D during their transition to adult care by enhancing their knowledge and motivation for self-management. Participant subgroups responded differently to various intervention components, which highlights that one-size-fits-all approaches are likely inadequate. Digital interventions should be developed and studied in a variety of…
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The psychological impact of the disclosure of the diagnosis of Alzheimer’s disease on informal caregivers
INTRODUCTION: Receiving an Alzheimer’s disease (AD) diagnosis can be a distressing experience, for both the individual with the condition and the family. This cross-sectional study explored whether the disclosure of AD diagnosis generated post-traumatic stress symptoms (PTSSs) in caregivers and how this affected their psychological well-being.