Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of Blueberry Supplementation on Depression and Anxiety Symptoms in a Rural Louisiana Population
Background/Objectives: Blueberries are an important nutraceutical due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins. These compounds can improve mood, cognition, and health. As such, blueberry consumption can potentially benefit those coping with depression and anxiety. In this regard, there is an unmet need for novel, effective, and accessible treatments…
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Marine omega-3 PUFA Supplementation Enhances FFAR4 Activation and Reduces Inflammatory Markers in PBMC of Subjects with Obesity: A Randomized Controlled Trial (EPICO)
Background: It is widely accepted that low-grade chronic inflammation in obesity worsens the metabolic state and threatens patients’ lives in a long-term manner. In fact, diet therapy is the first-line treatment in which relevant nutrients such as the omega-3 polyunsaturated fatty acids (ω-3 PUFA) must be adequately consumed to counteract the established inflammation. In particular,…
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Efficacy of Baduanjin Exercise for Sarcopenia in Older Adults: A 24-Week Randomized Controlled Trial
CONCLUSIONS: Regular BE markedly improved muscle function and increased muscle mass in older adults with sarcopenia, indicating a safe and effective exercise for sarcopenia management. BE, which was tailored using the short physical performance battery assessment, offers a valuable approach to help prevent and treat sarcopenia in older adults. Future research should investigate the long-term…
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Fractional Flow Reserve to Guide Revascularization in Patients With Coronary Artery Disease Undergoing TAVR
CONCLUSIONS: Conservative management of FFR ≤0.80 lesions was linked to higher cardiovascular risk compared with either PCI of FFR ≤0.80 lesions or deferral of FFR >0.80 lesions, which had similar outcomes. These findings support an FFR threshold of 0.80 to guide coronary revascularization in patients undergoing TAVR. (Revascularization in Patients Undergoing Transcatheter Aortic Valve Implantation…
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Patient Portal Engagement in Oncology: Results From the NU IMPACT Study in a Large Health Care System
CONCLUSION: Portal use among patients with cancer varies by sociodemographic and clinical characteristics. Findings suggest a need for targeted interventions to promote equitable use among under-represented groups and promote portal-based PRO completion for patients with higher symptom burden.
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Effects of dry needling and kinesio taping in temporomandibular dysfunction: a randomized trial
CONCLUSION: Dry needling and kinesio taping are effective, safe, and clinically feasible interventions for the management of TMD. Dry needling, in particular, appears more effective in reducing pain and improving function. These findings highlight the importance of incorporating conservative physical therapy approaches within multidisciplinary TMD treatment protocols.
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Neoadjuvant Immunotherapy With Prolgolimab in Patients With Locally Advanced Microsatellite Instability/Defective Mismatch Repair Colorectal Cancer
CONCLUSION: The use of prolgolimab in locally advanced dMMR/MSI CRC is associated with high rates of pCR and cCR, allowing for further exploration of organ-sparing approaches in these patients.
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Effect of core stabilization exercises on antioxidant/oxidant levels in hypertensives
CONCLUSION: Core stabilization exercises may improve oxidative balance and endothelial function in patients with hypertension.
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Cognitive function during endocrine treatment with or without cyclin-dependent kinase 4/6 inhibitors for advanced breast cancer
CONCLUSIONS: Patients with HR^(+)HER2^(-) ABC showed impaired cognitive function at initial diagnosis compared to cancer-free controls. During first-line endocrine treatment with aromatase inhibitors, cognitive function declined in a small group of patients, regardless of the addition of CDK4/6i.
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Oral Lacticaseibacillus rhamnosus GG Exposure During Pregnancy and Effects on Maternal Inflammatory Response-A Blinded, Pilot Randomized, Placebo-Controlled Study
CONCLUSIONS: Although L. rhamnosus GG did not significantly affect TNF-α levels, its influence on lymphocyte and cytokine levels warrants further investigation through larger trials.