Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of tricalcium silicate-based intracanal dressing on antibacterial-antifungal activity and postoperative pain intensity after non-surgical endodontic retreatment: randomized controlled clinical trial
CONCLUSIONS: Both materials were effective in reducing microbial load; however, calcium hydroxide demonstrated superior antibacterial efficacy. Antifungal activity and postoperative pain outcomes were comparable between the groups.
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Vonoprazan attenuates proteinuria in diabetic kidney disease through potential direct renal mechanism
Our study investigates the effect of vonoprazan on albuminuria in diabetic kidney disease (DKD) patients compared to lansoprazole through a randomized controlled trial. Participants were randomized to receive either lansoprazole 30 mg or vonoprazan 20 mg. Specifically, 100 patients were included for H. pylori eradication, and 40 patients for other indications. The albumin/creatinine ratio (ACR)…
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Randomized crossover trial of hand and hydrostatic casting for custom lower limb prosthetic sockets: Assessing socket comfort and fabrication time
The aim of this study was to compare diagnostic sockets made by hand casting and standing hydrostatic pressure casting in persons with lower limb amputation. This multi-site, single-masked, randomized crossover trial (ClinicalTrials.gov NCT04141748) involved a prosthetist at each site taking one cast by hand (H) and another using hydrostatic casting (S). The process of casting,…
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Comparative analysis of postoperative results of various methods of treatment of inguinal hernias
To assess and compare the long-term postoperative complications, postoperative pain incidences, and hernia recurrence rates following surgery for inguinal hernias using different surgical approaches, namely transabdominal preperitoneal (TAPP), TAPP with the internal ring suturing (TAPP-IRS), Liechtenstein technique, and Shouldice technique. This study is a multicentre clinical trial that involves 302 patients ranging from 18 to…
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Automated Oxygen Delivery in Home Setting for Patients with COPD on Long-Term Oxygen Therapy — A Randomized Crossover Feasibility Trial
CONCLUSION: Automated oxygen titration is feasible in the home setting, achieving more time with normoxia, but it required a wide flow range and continuous SpO2 monitoring. The patients reported a clinically relevant reductions in COPD symptoms measured with CCQ. The clinical importance of controlling SpO(2) needs to be examined in a larger study.
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Effectiveness of transcranial direct current stimulation on emotional instability and impulsivity in atypical depression and bipolar II disorder
Atypical depressive disorder and bipolar disorder often present with symptoms like emotional instability and impulsive behaviors. Various treatments, both pharmaceutical and non-pharmacological, are employed to manage these conditions. Transcranial direct current stimulation (tDCS) is a modern treatment option that has shown promise with minimal side effects. This study aims to compare the effectiveness of tDCS…
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Comparison of Oral Desensitization with Heated Cow’s Milk Products with Conventional Desensitization Method in Children with Cow’s Milk Allergy
Cow’s milk allergy (CMA) is one of the most prevalent Immunoglobulin E (IgE)-dependent food allergies in children. Currently, the only accepted treatment for food allergy is avoiding the relevant allergen. The purpose of this study is to investigate the immunological changes following the consumption of heated cow’s milk products compared to the usual method of…
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Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study
Endurance exercise may be associated with acute damage to intestinal epithelial cells. The effect of caffeine supplementation, and whether this is influenced by common genetic polymorphisms (ADORA2A: rs5751876 and CYP1A2: rs762551), is not currently known. Participants (n = 18 men and women) ingested caffeine (3 mg/kg body mass) or placebo 45 min before cycling (20…
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TRPM8 Agonist (Cryosim-1) Cream for Chronic Prurigo: A Randomized, Vehicle-controlled Trial
Chronic prurigo (CP) is a distressing dermatological condition lacking effective topical therapies. This randomized, double-blind, vehicle-controlled trial evaluated the efficacy and safety of Cryosim-1, a TRPM8 agonist cream, in 30 adults with CP. Participants were assigned to apply Cryosim-1 0.1%, 0.5%, or vehicle cream 3 times daily for 4 weeks. Both active formulations significantly reduced…
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Tripartite strategy for dual reduction of radiation and iodine dose in obese CCTA: High-iodine contrast, 80 kVp, and deep learning reconstruction
Coronary CT angiography (CCTA) in obese patients is challenging due to high radiation exposure, elevated iodine load, and increased image noise. We evaluated a tripartite low-dose strategy combining high-iodine-concentration contrast media (HCM, 400 mgI/mL), 80-kVp scanning, and deep learning image reconstruction (DLIR) in obese patients (BMI ≥30 kg/m2) to simultaneously reduce radiation and iodine dose…