Clinical Trials
Category Added in a WPeMatico Campaign
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Phase II randomised, placebo-controlled study to evaluate the efficacy and safety of an MK2 inhibitor in ankylosing spondylitis
CONCLUSIONS: Inhibition of MK2 by CC-99677 was insufficient to lead to significant clinical benefits in AS.
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Effect of Integrated Internet-Based Acceptance and Commitment Therapy and Behavioral Activation Among Ethnic Minority Young Adults With Alcohol Use Disorder in Hong Kong: Pilot Randomized Controlled Trial
CONCLUSIONS: This study, unlike existing evidence, presents an innovative integration of ACT and BA delivered via an internet-based self-help format. The findings contribute to the field by providing preliminary evidence that this integrated intervention is feasible and promising for AUD. The main implication in the real world is to conduct a fully powered randomized controlled…
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Echocardiographic Parameters for Predicting Atrial Fibrillation Following Ischemic Stroke: The PER DIEM Echocardiography Substudy
CONCLUSIONS: In patients with ischemic stroke, LAVI and LV GLS were significantly associated with subsequent AF detection. These findings may help risk stratify AF monitoring strategies for postischemic stroke management.
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Factors associated with unplanned healthcare encounters in pediatric cancer patients
CONCLUSIONS: Unplanned healthcare utilization is common among newly diagnosed pediatric cancer patients. The association between unplanned healthcare utilization and standardized symptom screening and increasing physical full-time equivalents warrant further investigation. Key aspects to the implementation of routine symptom screening among pediatric patients with cancer will be resource allocation to prevent and manage common symptoms including…
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Sustained on/off-treatment disease control with abrocitinib for moderate-to-severe atopic dermatitis
CONCLUSIONS: After 12 weeks of abrocitinib 200 mg, some patients achieved 40 weeks of sustained off-treatment disease control, with assessments demonstrating clear/mild AD, suggesting attainment of disease remission.
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Absolute Eczema Area and Severity Index Responses with Lebrikizumab in Patients with Moderate-to-severe Atopic Dermatitis: A Secondary Analysis of Two Phase 3 Trials
The ADvocate trials (NCT04146363, NCT04178967) investigated adults/adolescents with moderate-to-severe atopic dermatitis (AD) receiving lebrikizumab (LEB) monotherapy, using percent improvement in the Eczema Area and Severity Index (EASI). In clinical trials, percent EASI improvement is used to compare study arms and measure treatment effect size/impact. In clinical practice, however, absolute EASI scores are used (especially in…
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Amino Acid Profile and Composite Metabolic Markers in Postsurgical Oncology Patients Receiving Combined Nutritional Therapy
CONCLUSION: Cancer patients following abdominal surgery exhibit a pronounced amino acid imbalance that is partially correctable by combined nutritional support. The BCAA/AAA, UreaCycle, and arginine indices reflect the metabolic response and correlate with disease severity and nitrogen balance. The rate of correction of these disorders is comparable in both the group receiving Aminoven 10% and…
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The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial
BACKGROUND: Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high levels of discontinuation, evidencing a need for alternatives. One possible avenue is serotonergic intervention, particularly within the serotonin synthesis pathway, where there are several potential loci of dysfunction in ADHD. This study…
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Effect of probiotics derivatives (postbiotics and metabiotics) on glycemic control in individuals with type 2 diabetes: a randomized clinical trial (DELI_Diab study)
CONCLUSIONS: Three-month supplementation with L. rhamnosus DV lysate significantly improves glycemic control (HbA1c) and reduces waist circumference compared to placebo in T2D patients. While positive trends in insulin sensitivity and anthropometrics were observed, further large-scale studies are required to confirm these metabolic benefits and assess long-term sustainability.
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Clinical efficacy of Fufang Zaofan Pills and their immunomodulatory effects on peripheral blood dendritic cells in individuals with lower-risk myelodysplastic syndrome
The aim of this study is to evaluate the clinical efficacy of Fufang Zaofan Pills in individuals diagnosed with lower-risk myelodysplastic syndrome (MDS) and to assess associated changes in peripheral blood dendritic cell (DC) levels. A cohort of 60 individuals with newly diagnosed lower-risk MDS were enrolled at the Department of Hematology, Jiading Central Hospital,…