Clinical Trials
Category Added in a WPeMatico Campaign
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Proteins linked to type II interferon response in Sjögren’s disease: novel indicators for disease monitoring and predicting treatment response to leflunomide and hydroxychloroquine combination therapy
CONCLUSION: These data support a significant role for a type II IFN-associated immune response in SjD pathogenesis, which is targeted by LEF/HCQ. Proteins associated with type II IFN-driven immune responses hold potential to monitor disease activity and predict treatment response.
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The effectiveness of symptom-oriented mind mapping combined with problem-based learning in critical care clerkships: a randomized controlled trial
CONCLUSION: The study demonstrated that the SOM-PBL approach significantly enhanced medical students’ knowledge integration and clinical decision-making efficiency during ICU clerkships. However, no significant improvement was observed in procedural skills. These findings offer both theoretical and practical value for innovating critical care medical education by effectively addressing knowledge fragmentation and bridging the theory-practice gaps.
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The anti-inflammatory effects of dexamethasone implants in eyes with heavy silicone oil: a prospective study on vitrectomy for diabetic retinopathy
CONCLUSION: To our knowledge, this first study of dexamethasone implants with HSO in PDR suggests intraoperative DEX may be a safe, potentially beneficial adjunct for diabetic TRD undergoing phacoemulsification plus vitrectomy with HSO, reducing inflammation and number of anti-VEGF injections over 3 months, and offering useful directions for future research in this preliminary prospective evaluation…
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Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Analysis for Clazakizumab in Patients With End-Stage Kidney Disease Undergoing Dialysis
The inflammatory cytokine interleukin-6 (IL-6) plays a significant role in the progression of cardiovascular disease (CVD). We evaluated the impact of clazakizumab, a monoclonal antibody targeting the IL-6 ligand, upon high-sensitivity C-reactive protein (hs-CRP) as part of the dose-finding phase 2b trial. In this randomized, double-blind trial, adults with cardiovascular disease and/or diabetes receiving maintenance…
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An interactive digital behaviour change intervention to decrease incidence of sexually transmitted infections among users of STI self-sampling websites: a feasibility RCT
CONCLUSIONS: A full trial is feasible. Despite the low recruitment rate, there are sufficiently high numbers of young people accessing web-based sexually transmitted infection testing (585,000 per year based on most recent data) to achieve the required sample. Suggested strategies to address the potential for under- and over-representation of some demographic subgroups at M12 should…
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Evaluating the impact of digital therapy for male LUTS: insights from the BEST trial subgroup analysis
CONCLUSION: The digital therapeutic achieved clinically meaningful symptom and quality-of-life improvements across all subgroups. Additional reductions in voiding frequency and high adherence support its broad applicability in clinical practice.
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Long-term efficacy of chlorhexidine-containing cutaneous dressings on ventriculostomy-related infection: a 10-year before-and-after study
CONCLUSIONS: The occurrence of EVDAIs was significantly reduced when using additional CHX dressings (8%), compared to silver-coated EVDs alone (19%), without extending antibiotic prophylaxis or using antibiotic-impregnated catheters as a valid alternative in terms of antibiotic stewardship. This finding should encourage the neurosurgical community to generate more awareness in using and evaluating postoperative measures that…
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Safety outcomes among infants whose mothers used the dapivirine vaginal ring or oral PrEP during pregnancy (MTN-042/DELIVER): a randomised phase 3b study
BACKGROUND: HIV acquisition risk during pregnancy remains high and additional data supporting pre-exposure prophylaxis (PrEP) in pregnancy are needed. The aim of the MTN-042/DELIVER study was to evaluate the dapivirine vaginal ring (DVR) and daily oral tenofovir disoproxil fumarate plus emtricitabine use as PrEP during pregnancy. We report infant outcomes following confirmed in-utero exposure.
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The effect of education with WhatsApp application on women’s health beliefs, self-efficacy levels, and regular mammography behavior: a randomized controlled experimental trial
CONCLUSION: Health Belief Model-based education delivered via WhatsApp positively affected women’s health beliefs and mammography behaviors, demonstrating the effectiveness of education delivered through digital platforms.
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Poor health-related quality of life despite Lupus Low Disease Activity State or Definitions of Remission in systemic lupus erythematosus (SLE) remission in patients with SLE: results from a clinical trial setting
CONCLUSIONS: Despite LLDAS or DORIS remission, notable proportions of SLE patients report poor HRQoL, indicating that current therapeutic goal definitions do not fully capture patients’ perspectives of health.