Clinical Trials
Category Added in a WPeMatico Campaign
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Dupilumab efficacy by disease severity in pediatric type 2 asthma
CONCLUSION: Long-term dupilumab treatment reduced exacerbation rates and improved lung function and asthma control in children with type 2 asthma irrespective of disease severity, with numerically greater improvements in children with severe asthma.
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Endolysin significantly improves symptoms with atopic dermatitis: bridging the gap from research to clinical practice
CONCLUSIONS: Topical endolysin gel is a well-tolerated, effective, and promising agent for the treatment and proactive maintenance of mild-to-moderate AD in adults.
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Comparative efficacy and safety of topical caspofungin 0.5% and voriconazole 1% for fungal keratitis: a pilot clinical trial
To compare the efficacy of topical caspofungin 0.5% with topical voriconazole 1% in patients with fungal keratitis. In this pilot clinical trial, thirty-four eyes from 34 patients diagnosed with fungal keratitis, confirmed by positive smear or culture results or in vivo confocal microscopy (IVCM), were included in the study. Patients were randomized to receive either…
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Testing two digital stress-management interventions in a randomized controlled trial of breast cancer patients
The digital stress-management intervention StressProffen has been shown to be associated with improved well-being and quality of life for cancer survivors. In the Coping After Breast Cancer (CABC) trial, effects of 6 months’ access to modified versions of StressProffen, delivered through a digital download-only model, were examined. Women with breast cancer were invited to participate…
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Impact of early FAST ultrasound on severe trauma outcomes: a randomized trial in a low-resource African emergency setting (The ALIFAST Trial)
CONCLUSION: Early use of FAST significantly reduced mortality, CT use, and surgical delays. These findings support guideline recommendations for integrating FAST into trauma triage protocols, particularly in LMICs.
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Randomized target engagement trial of a dissonance-based transdiagnostic eating disorder treatment versus transdiagnostic interpersonal psychotherapy
CONCLUSIONS: Results provide further evidence of target engagement for BPT and suggest that it is more effective than IPT in treating a range of eating disorders.
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Anabolic Effects of Salbutamol Are Lost Upon Immobilization
CONCLUSIONS: Salbutamol increases muscle mass and glucose uptake, although these effects are limited to active but not inactive muscles. This demonstrates that the mechanism of action and efficacy of β2-adrenoreceptor signalling are hampered upon immobilization, which offers potential for a combined treatment intervention of reintroducing muscle contraction and salbutamol administration to improve muscle mass and…
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Ethical issues in a cluster randomised controlled trial for evaluating effectiveness of screening for breast cancer by clinical breast examination in India
This article discusses issues of ethical concern in the conduct of a prospective, cluster randomised controlled trial for evaluating effectiveness of screening by clinical breast examination for downstaging of breast cancer, and in reducing mortality from the disease, in comparison to no screening. This trial was conducted in Mumbai, India, over 20 years, from May…
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A Randomized Controlled Trial Comparing Time for Tracheal and Pleural Ultrasonographic Confirmation of the Correct Placement of the Endotracheal Tube in Overweight and Obese Patients
CONCLUSION: Tracheal USG provides a faster confirmation of endotracheal intubation than pleural USG in overweight and obese patients. Pleural USG has the added advantage of diagnosing endobronchial intubation.
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Effect of low-concentration at-home bleaching gels on whitening and tooth sensitivity: a split mouth randomized clinical trial
CONCLUSIONS: Both products effectively whitened teeth while inducing mild tooth sensitivity, and both had a positive socio-psychological impact. The 3% HP gel provided a bleaching efficacy advantage, while the 8% CP gel demonstrated lower sensitivity and less enamel alteration.