Clinical Trials
Category Added in a WPeMatico Campaign
-
Eye tracking as a novel approach to cognitive assessment in DOC patients based on evidence from a multicenter clinical trial
The proper assessment of cognitive functioning is the subject of numerous scientific studies. Current behavioral methods essentially preclude this assessment in patients with disorders of consciousness (DOC). However, the development of eye-tracking technology (ETT) and the establishment of contact via this channel have created an opportunity to diagnose the cognitive function (CF) of DOC patients.…
-
Effects of music and conversation on pain and anxiety levels during transrectal ultrasound-guided prostate biopsy: a randomized-controlled prospective study
CONCLUSIONS: The study demonstrated that listening to music had no significant effect on pain and anxiety in patients undergoing TRUS-PBx. Conversely, the findings showed that engaging patients in conversation significantly reduced pain and anxiety during the procedure.
-
Home-based diabetes self-management education and support through Orem’s self-care model: a randomized controlled trial
The aim of this study was to provide health interventions by integrating the Diabetes Self-Management Education and Support recommended by the American Diabetes Association with Orem’s self-care model to address the challenges in diabetes self-management. This research is a randomized controlled experimental research. Sixty-five diabetic patients (30 controls, 35 experimental) were included in the study.…
-
Impact of partial restoration margin level in combination with connective tissue graft on the treatment of single RT1 gingival recessions associated with non-carious cervical lesions: a 1-year randomized parallel-group trial
CONCLUSIONS: PR margins at or 1 mm apical to the CEJ provided similar clinical and esthetic outcomes when combined with CAF + CTG. The CEJ-1 approach improved early patient comfort without compromising root coverage.
-
Randomized clinical trial of vaginal microbiota in menopausal genitourinary syndrome using radiofrequency and topical estriol
CONCLUSION: There was improvement in the parameters analyzed regarding the vaginal microbiota in the intervention with FRAXX with a higher proportion of Lactobacillus and a decrease in pH. And there was no superiority of FRAXX in relation to the use of topical estriol.
-
Efficacy of Exercise on Severity of Paclitaxel-Induced Peripheral Neuropathy and Improving Quality of Life in Women with Non-metastatic Breast Cancer: Results of an Interim Analysis from an Ongoing Randomized Clinical Trial (ExPIN Trial)
CONCLUSIONS: Exercise intervention during paclitaxel therapy significantly reduced PIPN severity and improved quality of life. Findings are preliminary and warrant further confirmation.
-
Five-Year Outcomes of a Dialectical Behaviour Therapy Skills Training Group Versus Supportive Group Training for Individuals With Nonsuicidal Self-Injury: A Randomized Controlled Study
CONCLUSION: At the sample level, DBT-ST yielded larger and more durable gains than SSGT-primarily among adults-whereas adolescent effects were smaller, heterogeneous and not consistently significant. Long-term endpoints addressed symptoms and diagnostic status; NSSI episode frequency was not quantified longitudinally. Anxiety diagnoses increased in both arms, underscoring the need for routine anxiety screening and targeted management…
-
Efficacy of fourteen-day once-daily vonoprazan-based quadruple therapy for Helicobacter pylori in high clarithromycin-resistance regions (ONCE-VONO Trial)
Vonoprazan, a novel and potent acid suppressant, has recently been incorporated into Helicobacter pylori eradication regimens. However, the data on combination of vonoprazan with levofloxacin remains scarce. This study represents one of the first evaluations comparing 7-day and 14-day once-daily regimens containing vonoprazan, levofloxacin, clarithromycin-MR, and bismuth for H. pylori eradication in regions characterized by…
-
O04 Mission EB -mesenchymal intravenous stromal cell infusions in children with recessive dystrophic epidermolysis bullosa: a randomised, double-blinded, placebo controlled, crossover trial
Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a severe type of epidermolysis bullosa resulting from mutations in COL7A1 gene. Patients experience various degrees of blistering following minor trauma which can over time lead to fibrosis, limb contractures and an increased risk of developing squamous cell carcinoma. The aim was to assess if repeated infusions of allogeneic…
-
Comparison between two bone anchored force systems for correction of skeletal Class II malocclusion in growing patients: a randomized controlled clinical trial, part 2: short-term dentoalveolar changes
CONCLUSIONS: The use of either pushing or pulling force mechanics using bimaxillary skeletal anchorage was effective in improving Class II dental relationships without dentoalveolar side effects. Pretreatment transverse discrepancy should be assessed to incorporate maxillary expansion into the treatment protocol for patients diagnosed with maxillary arch constriction.