Clinical Trials
Category Added in a WPeMatico Campaign
-
Prevalence and Incidence of Chlamydia trachomatis and Neisseria gonorrhoeae Among Women Who Initiated HIV PrEP During Pregnancy in Kenya
CONCLUSIONS: CT/NG incidence was high among women who initiated preexposure prophylaxis in pregnancy, indicating that CT/NG testing would be high yield in this population.
-
Impact of hypnosis during coronarography
CONCLUSION: Our results demonstrated a significant reduction of perceived pain, anxiety, and use of analgesic drugs in hypnosis responder patients. Hypnosis could be an alternative or complementary method to improve patient comfort significantly, during coronarography.
-
Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein as Treatment for Gout Flare
CONCLUSION: Etanercept might be contemplated for «off-label» use in gout patients who do not respond to standard therapy or glucocorticoid therapy, encounter severe side-effects and contraindications.
-
ESTREL-Fatigue-association of levodopa with post-stroke fatigue
CONCLUSION: In ESTREL-Fatigue, levodopa, compared to placebo, was not associated with less PSF during in-hospital rehabilitation.
-
Efficacy of 1064-nm Picosecond Laser in the Treatment of Lichen Planus Pigmentosus: A Split-Face Randomized Controlled Trial
CONCLUSION: The 1064-nm picosecond laser demonstrated limited effectiveness in improving LPP clinical outcomes. Further studies with sham-controlled trials and larger sample sizes are needed to optimize treatment parameters and sessions, and to validate the role of the picosecond laser as a therapeutic option for LPP.
-
No Evidence for Changes in Emotional Reactivity Following a 12-Week Exercise Intervention: A Randomized Controlled Trial
Physical exercise is associated with numerous psychological benefits, and recent studies suggest it may modulate emotional reactivity-typically enhancing responses to positive stimuli and attenuating responses to negative ones. However, most existing evidence concerns acute effects following a single exercise session, leaving it unclear whether regular exercise can induce more stable changes in emotional reactivity. To…
-
Efficacy and Safety of 590 Nm and 590/630 Nm Light-Emitting Diode Therapy for Sensitive Skin: A Prospective Randomized Controlled Trial
CONCLUSIONS: LED light therapy, particularly 590 nm yellow light, is a safe and effective modality for alleviating SS symptoms, with dual-wavelength therapy showing complementary benefits.
-
Prevalence of presbyopia among social safety net beneficiaries with the cognitive, numeracy and dexterity skills required for smartphone use: a cross-sectional analysis of THRIFT RCT screening data from Kurigram, Bangladesh
CONCLUSIONS: This study highlights a substantial burden of uncorrected presbyopia among a prescreened, randomised control trial-eligible subgroup of social safety net beneficiaries in rural Bangladesh, who were not currently using MFS but demonstrated cognitive and functional capacity to use mobile phones, potentially hampering their ability to carry out online banking. Delivery of reading glasses may…
-
Social Media Intervention Based on the Information-Motivation-Behavioral Skills Model Promotes HIV Testing and Reduces High-Risk Behaviors Among Men Who Have Sex With Men in Resource-Limited Settings in China: Randomized Controlled Trial
CONCLUSIONS: The social media intervention guided by the IMB model demonstrated a positive effect on expanding HIV testing coverage, reducing high-risk behavior, enhancing AIDS-related knowledge, and improving safer sex self-efficacy among men who have sex with men in resource-limited settings. These findings provide valuable guidance for future HIV prevention and control efforts targeting this population.
-
Safety, tolerability, and efficacy of atogepant added to onabotulinumtoxinA for the preventive treatment of chronic migraine: A phase 3, multicenter, 24-week, open-label study
BackgroundTreatment with onabotulinumtoxinA is effective in reducing migraine day frequency and duration in individuals with chronic migraine (CM), but given the severity of the disease, those with CM often need additional treatment to achieve optimal outcomes. Combining preventive treatments with distinctly different physiological targets may yield greater benefit than monotherapy. This study evaluated the safety,…