Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of orofacial myofunctional therapy with auto-monitoring on the apnea-hypopnea index in patients with mild-to-moderate obstructive sleep apnea: a multicenter randomized controlled trial
CONCLUSION: Twelve weeks of standardized OMT had no significant effect on AHI, desaturation measures or ESS score in treatment-naive patients newly diagnosed with OSA.
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Changes in self-related cognitive processes and depressive symptom severity following a single, moderate dose of psilocybin in depressed patients
Psychedelic-assisted therapy, particularly with psilocybin, is increasingly proposed as a treatment for major depressive disorder, yet the neural and psychological mechanisms underlying its effects remain under investigation. In a randomized, double-blind, placebo-controlled clinical trial, individuals diagnosed with major depressive disorder received a single, moderate dose of psilocybin (0.215 mg kg-1) or placebo, with the same…
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Inhaled Corticosteroids and Sickle Cell Disease Severity in Adults Without Asthma: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this trial of adults with SCD and ECW, extended courses of inhaled mometasone were associated with worsened markers of disease severity. Inhaled mometasone should not be used long-term in patients with SCD and ECW without a definitive diagnosis of asthma.
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Influence of diabetes mellitus on dapagliflozin response after transcatheter aortic valve replacement (TAVR): insights from the DAPA-TAVI trial
CONCLUSIONS: In this pre-specified subanalysis of the DAPA-TAVI trial, dapagliflozin significantly reduced the risk of death or worsening HF in patients with DM undergoing TAVR, with a favorable benefit-risk profile, whereas a more modest and non-significant effect was observed in non-DM patients. Although no statistically significant interaction according to diabetes status was observed, the apparently…
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Baduanjin improves motor function and cortical activation in children with developmental coordination disorder: a randomized controlled trial
CONCLUSIONS: Baduanjin training improved motor coordination and balance in children with DCD. The observed changes in activation within motor-related cortical regions provide preliminary support for a possible neurophysiological basis of these functional improvements, although the underlying mechanisms require further investigation.
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Patient Engagement in a Virtual Cardiac Rehabilitation Platform: Secondary Analysis of the ERA-Nudge Trial
CONCLUSIONS: Among an urban safety-net population, text message nudges were associated with greater time in the app compared to nudges delivered as app notifications. These findings suggest that text messages may result in greater patient engagement for mobile health interventions.
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Prevalence and Consequences of Guideline-Directed Indications for Aortic Valve Replacement in the EARLY TAVR Trial
CONCLUSIONS: Among patients in the EARLY TAVR trial, Class II indications for AVR were present in almost one-third of patients at baseline. The benefit of early TAVR was consistent regardless of the presence or absence of Class II indications. These findings support the strategy of early TAVR over CS in asymptomatic patients with severe AS,…
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Adjunctive Treatment with Subconjunctival and Topical Bevacizumab to Prevent Recurrence after Excision of Primary Pterygium: A Multi-centric Trial
CONCLUSIONS: When used as an adjunct, both subconjunctival and topical bevacizumab reduce the recurrence rate following primary pterygium excision with conjunctival autografting.
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BAK-preserved hyaluronate and corneal nerves
CONCLUSIONS: This substudy detected no between-group difference in corneal subbasal nerve parameters.
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Effects of Group-Based CBT/ERP and ACT on Emotion Dysregulation, Sleep, Anxiety Sensitivity and Psychological Flexibility in Adults With OCD
CONCLUSIONS: In line with our hypotheses, our results indicated that ACT may be non-inferior to CBT/ERP for all secondary outcomes. However, as the trial was powered for the primary outcome (symptom severity) rather than for these secondary measures, our findings should be interpreted as suggestive. Nonetheless, these findings add to the growing evidence that ACT…