Clinical Trials
Category Added in a WPeMatico Campaign
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Optimization of Anticoagulation Strategy During Cardiopulmonary Bypass in Neonates with Congenital Heart Disease: A Randomized Controlled Trial
CONCLUSION: An initial heparin dose of 600 U/kg in neonatal CPB was associated with a smaller F1+2 increase and greater initial ACT response. Larger studies are needed to establish clinical benefit and safety.
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Efficacy and tolerability of co-administration of clozapine with atypical antipsychotics in patients with treatment-resistant schizophrenia, comorbid with chemical addictions
CONCLUSIONS: A comprehensive treatment strategy for therapeutically resistant schizophrenia, irrespective of concomitant addictions, is the combination of clozapine with cariprazine; lurasidone serves as an alternative option. The selection of an effective adjunctive therapy should consider the specific type of addiction: lurasidone or aripiprazole is recommended for cannabinoid, psychostimulant, and alcohol dependencies; risperidone or olanzapine is…
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Entinostat plus exemestane for hormone receptor-positive advanced breast cancer: long-term overall survival results from the EOC103A3101 randomized controlled trial
The addition of entinostat, a histone deacetylase inhibitor, to exemestane has demonstrated improved progression-free survival (PFS) in hormone receptor-positive (HR + ), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) following endocrine therapy failure in the EOC103A3101 randomized trial (NCT03538171). This study reports long-term overall survival (OS) results. In this study, 354…
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Miro1 mediates skeletal muscle insulin resistance in type 2 diabetes
Imbalanced skeletal muscle mitochondrial dynamics contribute to the onset and progression of type 2 diabetes (T2D) by mechanisms that remain incompletely understood. Here, we examined the role of Mitochondrial Rho GTPase 1 (Miro1), an outer mitochondrial membrane enzyme, in regulating skeletal muscle insulin action and glucose homeostasis in type 2 diabetes (T2D). In a cross-sectional…
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Artificial intelligence-assisted training for proximal caries diagnosis by undergraduate dental students: a randomized experimental study
CONCLUSIONS: AI-assisted training did not significantly improve students’ diagnostic competency in proximal caries detection compared with conventional radiology training. However, AI training improved diagnostic efficiency, as indicated by the lower absolute average errors, and did not impair students’ independent radiographic interpretation when AI support was removed. AI may serve as a supportive adjunct in undergraduate…
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Efficacy of Saffron as an Adjunct to Methylphenidate in Treating ADHD in Children Aged 6-12: A Randomized Clinical Trial
CONCLUSION: The findings suggest that the combination of saffron with methylphenidate may enhance subjective reports of ADHD symptoms, particularly hyperactivity and impulsivity; however, objective cognitive measures showed limited changes. Given the favorable safety profile of saffron and study limitations, this supports its potential role as a complementary option, pending confirmation in placebo-controlled trials with larger…
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Long-term efficacy of lebrikizumab in treating head, neck and face involvement in patients with moderate-to-severe atopic dermatitis
CONCLUSIONS: Lebrikizumab provided durable, stable long-term HNF efficacy across diverse populations, including systemic-naive patients and those with prior biologic exposure.
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Gut Regulated Associations of Neuronal Signalling in High Blood Pressure (GRAINS-BP): a double-blinded randomised crossover placebo-controlled trial
BACKGROUND: Hypertension affects 1 in 3 Australian adults and is a major contributor to stroke and myocardial infarction. Despite the availability of various medications, over 50% of patients struggle to control their blood pressure (BP) due to nonadherence, difficulty finding the right treatment, or avoidance of medication. Diet plays a key role in cardiovascular health,…
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Effect of a Subanesthetic Dose of Esketamine on Postoperative Sleep Disturbance After Oocyte Retrieval Under Intravenous Anesthesia: A Randomized Controlled Trial
CONCLUSION: A single subanesthetic dose of esketamine was associated with a lower incidence of short-term PSD on POD 3 in women undergoing oocyte retrieval under intravenous anesthesia. Larger multicenter studies are warranted to confirm these findings.
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Full-spectrum LED screen-bar lighting as an adjunct to artificial tears in visual display terminal-related dry eye: a randomized study
CONCLUSIONS: Adding a full-spectrum lamp to artificial tears was associated with a greater short-term improvement in subjective dry eye symptoms in VDT-related dry eye, without corresponding between-group differences in objective ocular surface parameters. Further studies are required to confirm these findings. Trial registration number ChiCTR2400084309, 2024/05/14.