Clinical Trials
Category Added in a WPeMatico Campaign
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Fissios and postoperative complications (FPoC trial): a multicentre, randomised, controlled clinical trial
INTRODUCTION: Respiratory physiotherapy as a part of a perioperative physical training programme may reduce the risk of developing postoperative complications in patients diagnosed with non-small cell lung carcinoma (NSCLC) scheduled for surgery. However, there is heterogeneity in the design, implementation and evaluation of respiratory physiotherapy programmes.Fissios App contains a standardised respiratory physiotherapy programme. Analysing the…
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Diagnostic stewardship in emergency departments using the UNTIE framework: a stepped-wedge cluster randomised study protocol
INTRODUCTION: Pathology testing accounts for over half of non-labour costs in Australian Emergency Departments (EDs), yet up to one-fifth of tests are unnecessary. Despite national guidance from the Australasian College for Emergency Medicine (ACEM) and the Royal College of Pathologists of Australasia (RCPA), variation in test ordering persists across departments and across clinical presentations. The…
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Learning Gain and User Experience of AI Avatar-Based and Human-Presented Explainer Videos: Prospective Randomized Crossover Feasibility Study
CONCLUSIONS: This study shows that investigating AI-based explainer videos vs those using a human presenter in classroom settings is feasible and highlights methodological challenges, particularly those related to crossover designs involving content-identical materials. In this small exploratory sample, no significant differences in short-term learning gains were detected between different presentation formats. Nonetheless, participants clearly preferred…
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Cancer caregiver support system: A pilot study to assess the effect of improved caregiver support on postoperative recovery of oral cancer patients
CONCLUSION: The CCSS intervention demonstrated feasibility and acceptability, with early signals of benefit in reducing caregiver strain and postdischarge disruptions. This pilot study underscores the potential of context-sensitive, digitally enabled caregiver support in resource-constrained oncology settings. Further scale-up and integration with AI-driven personalization are planned.
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10-Year Randomized Outcomes of Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Aortic Stenosis
CONCLUSIONS: At the 10-year follow-up, TAVR in intermediate-risk patients with the SAPIEN XT prosthesis compared with surgery was associated with lower survival rates, with differences predominantly observed in the TA/TAo access cohort. TAVR with the XT valve was also associated with significantly higher rates of aortic valve reintervention. (PARTNER II Trial: Placement of AoRTic TraNscathetER…
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10-Year Outcomes of SAPIEN 3 Transcatheter Aortic Valve Replacement or Surgery in Intermediate-Risk Patients
CONCLUSIONS: At 10 years, TAVR with the SAPIEN 3 valve and surgery resulted in similar rates of mortality and aortic valve reintervention, and similar hemodynamics in intermediate-risk patients with symptomatic severe aortic stenosis. This analysis highlights challenges associated with extended long-term follow-up of clinical trials, including differential loss to follow-up and the competing risk of…
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Novel use of arm ergometry cardiopulmonary exercise testing for non-elective patients with chronic limb-threatening ischaemia: a feasibility trial
CONCLUSIONS: CPETarm is a feasible, safe and acceptable method for preoperative assessment in patients with CLTI who are unsuitable for conventional lower-limb CPET. Further research is required to establish modality-specific thresholds, evaluate prognostic value for postoperative outcomes and evaluate integration into perioperative care pathways.
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Effectiveness and cost-effectiveness of risk-based topical fluoride intervention on early childhood caries in Jiangnan District, Nanning City
CONCLUSIONS: The PSC-MCAT tool is effective and cost-effective for caries risk assessment and may serve as a practical framework for caries prevention.
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The time sensitivity of aspirational interventions: Evidence from a role-modeling RCT
This paper investigates the short-run effects of an aspiration-raising intervention delivered as part of a randomized controlled trial among postgraduate students at a UK university during the Covid-19 pandemic. We document suggestive evidence, that a video-based role-modeling intervention led to an immediate increase in aspirations and a delayed increase in self-reported effort. However, both effects…
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Community Optometrist-Led Monitoring of Quiescent Neovascular Age-Related Macular Degeneration: The FENETRE Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, community optometrist-led monitoring of quiescent nAMD was noninferior to hospital monitoring for detecting disease activity requiring treatment. These results provide evidence for its use in integrated clinical care models.