Clinical Trials
Category Added in a WPeMatico Campaign
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Probiotic Supplementation Enhances the Effects of a Nutritional Intervention on Quality of Life in Women with Hashimoto’s Thyroiditis-A Double-Blind Randomised Study
Background: Hashimoto’s thyroiditis (HT) is characterised by chronic inflammation of the thyroid gland. The impact of a health-promoting diet and probiotics on health and quality of life, as well as on the anti-thyroid peroxidase antibody (anti-TPO), is increasingly being researched. However, the relevance of these factors to the course of HT is yet to be…
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Rapid Late Gadolinium Enhancement Cardiac MRI in Real-World Clinical Practice: A Prospective Clinical Trial
Purpose To compare two rapid late gadolinium enhancement (LGE) cardiac MRI sequences-phase-sensitive inversion recovery (PSIR) single-shot true fast imaging with steady-state precession (TrueFISP) and motion-corrected TrueFISP PSIR (moco PSIR)-with the PSIR turbo fast low-angle shot (turboFLASH) sequence regarding image quality, localization, and quantification of LGE. Materials and Methods This prospective study included consecutive participants who…
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Postoperative pain following root canal treatment with XP-Endo Finisher-assisted irrigant activation: a double-blind randomized controlled trial
CONCLUSIONS: The XP-Endo Finisher resulted in reduced early postoperative pain compared to needle irrigation at specific time points, although both methods showed similar outcomes in long-term pain resolution and analgesic consumption. Improved irrigant activation may influence short-term postoperative comfort.
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Educational program based on health belief model on knee osteoarthritis pain management in Iranian peri menopausal women: a randomized parallel controlled study
CONCLUSION: This study could be a scientific basis for future studies in research centers that work to promote self-management behaviors among KOA patients and improve the health systems of their countries.
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Wearable Augmented Reality for Nystagmus Examination in Patients With Vertigo: Randomized Crossover Usability Study
We demonstrate the feasibility of a wearable, augmented reality-based nystagmus examination system, showing its preliminary diagnostic agreement with conventional video-oculography and its potential for portable vestibular assessment in patients with vertigo.
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Comparing botulinum toxin and biofeedback therapies for awake bruxism: a randomized clinical trial
CONCLUSION: Even though neither intervention improved pain nor psychosocial outcomes, BIO significantly reduced AB behaviors, indicating that BIO may be preferable for controlling AB behaviors in TMD patients.
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Uptake of community-based integrated HIV and sexual and reproductive health services for young people in Zimbabwe: the CHIEDZA study
CONCLUSIONS: An integrated HIV and SRH programme had high attendance and service uptake, with most clients accessing multiple service components per visit, including HIV testing. Provision of integrated HIV and SRH services may increase service engagement and uptake by young people and facilitate programme efficiency.
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Baseline Characteristics of the TOPaZ Study: Randomised Trial of Teriparatide and Zoledronic Acid Compared with Standard Care in Adults with Osteogenesis Imperfecta
CONCLUSIONS: The TOPaZ population represents a unique cohort with which to study the genetic epidemiology and outcome of OI in relation to bone density and biochemical markers of bone turnover. When the trial reports, it will also provide new insights into the effect of an anabolic therapy, followed by antiresorptive treatment in the management of…
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Effectiveness of strenghtning oropharyngeal myofunctional therapy combined with cervical spine exercises in mild to moderate obstructive sleep apnoea
CONCLUSION: The comprehensive 20-week OMT programme and cervical spine exercises showed no effectiveness in improving respiratory parameters, daytime sleepiness or quality of life in patients with mild to moderate OSA compared to hygiene- and diet-related measures alone. The null results observed in this study suggest relevant clinical implications, such as the limited efficacy of low-frequency…
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Opening the black box: defining true-negative outcomes in esophageal cancer screening — a population-based study
CONCLUSIONS: Individuals with normal Lugol staining should be considered the genuinely screening-negative population for esophageal cancer. A 10-year screening interval is recommended for normal-stained individuals, while 2-3 years are necessary for ND-LULs.