Clinical Trials
Category Added in a WPeMatico Campaign
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At-Home Transvaginal Pelvic Ultrasonography and Image Quality in Premenopausal Women: A Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This nonrandomized clinical trial of at-home pelvic ultrasonography in premenopausal women demonstrated that broad use of at-home gynecologic ultrasonography technology is feasible, safe, and preferred by participants and sonographers compared with in-clinic ultrasonography. At-home ultrasonographic imaging presented an innovative and clinically acceptable alternative to in-clinic care, providing opportunities for improved access to…
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Evaluating the Safety and Efficacy of Sirolimus Topical Gel 0.2% to Treat Acanthosis Nigricans
CONCLUSION: Sirolimus gel 0.2% was safe and effective for AN, producing early improvements in pigmentation, texture, and patient-reported outcomes. Larger randomized controlled trials are warranted to validate these findings.  .
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Efficacy and Tolerability of a Topical Pigment-Correcting Serum in Melasma and Postinflammatory Hyperpigmentation
CONCLUSIONS: The LTN serum is an effective treatment for improving melasma and PIH, particularly among participants with FST IV–VI.  .
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Stapokibart provides significant improvements in signs and symptoms of atopic dermatitis irrespective of prior systemic treatment: a post-hoc analysis of a phase 3 trial
CONCLUSIONS: Stapokibart demonstrated significant clinical efficacy and manageable safety in AD patients irrespective of prior systemic treatment.
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Clinical efficacy and electromyographic analysis of direct current hydrotherapy in the treatment of upper limb peripheral nerve injuries: A randomized controlled trial
PurposeThis study aimed to investigate the reparative effect and therapeutic efficacy of direct current hydrotherapy in the treatment of upper extremity peripheral nerve injury to provide a reference for the clinical treatment of peripheral nerve injury in the future.MethodBetween September 2022 and June 2023, 66 eligible patients with upper extremity peripheral nerve injury were enrolled…
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GABAergic Modulation of Brain Function During Prosaccade and Antisaccade Eye Movements: Evidence From Ultra-High-Field fMRI
Benzodiazepines act as positive allosteric modulators of the GABA(A) receptor and affect several motor and cognitive functions. By engaging perceptual-motor as well as inhibitory control processes, the antisaccade task was used in previous studies to investigate effects of benzodiazepines on behavioral performance. Using a randomized, double-blind, placebo-controlled within-subjects design, this study combined eye-tracking with BOLD…
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A Comparative Study Assessing the Effect of Balance Training with and without Taping on Mobility in Stroke Patients
CONCLUSION: Balance training with taping is more effective for the improvement of mobility than balance training without taping in sub- acute to chronic stroke patients.
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Preliminary examination of the validity of a behavioral mindfulness measure in adults with advanced cancer and their family caregivers
OBJECTIVES: The breath counting task (BCT) has shown evidence of validity as a behavioral measure of mindfulness in healthy populations but remains largely untested in clinical contexts. The BCT is a computerized measure of present-moment awareness based on breath-counting accuracy. This study provides a preliminary evaluation of its validity in adults with advanced cancer and…
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Sit-To-Stand Breaks to Optimize Cardiometabolic Health Effects Following Exercise in Sedentary Adults With Dyslipidaemia: A Randomized Crossover Trial
Current physical activity (PA) guidelines recommend reducing prolonged sitting in addition to increasing PA. In this regard, the complementary effects of standing breaks to interrupt sitting, in addition to exercise, have not yet been evaluated. This study tested whether exercise alone or exercise combined with standing breaks enhances cardiometabolic outcomes compared with prolonged sitting in…
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The use of teleorthodontics and artificial intelligence for orthodontic triage and screening in a publicly funded healthcare system: A crossover randomized controlled trial
CONCLUSIONS: Teleorthodontics combined with DM™ is a valid and reliable tool for orthodontic screening of patients with mild and severe malocclusions but cannot be used to confidently assign IOTN-DHC grade for patients with borderline malocclusion severity yet. The duration of screening is significantly shorter using TAI.