Clinical Trials
Category Added in a WPeMatico Campaign
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The relationship of oral malodor to gingivitis: cross-sectional epidemiology and longitudinal randomized clinical trial evidence
This research assessed the relationship between oral malodor, measured by halimetry and organoleptic grading, and gingivitis as measured by number of gingival bleeding sites (GBS). Two complementary clinical studies were examined. The first was a cross-sectional trial evaluating the association between volatile sulfur compounds measured by halimetry and organoleptic scores (0-5 scale). The second study…
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Working with underrepresented groups: lessons from the SCHEMA trial
There is a growing focus on ensuring research is accessible and inclusive to individuals traditionally not represented. To be truly inclusive, the broader context needs to be explored, as barriers might not only be linked to population characteristics but also to the complexity of their environment, and limited research opportunity within certain healthcare professions. The…
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The Effect of Audiovisual Education on Breast Cancer Screening and Fear Among Illiterate Women: A Double-Blind Randomised Controlled Trial
CONCLUSION: Audiovisual education with breast model simulations effectively enhances screening behaviours and reduces fear among low-literacy populations. Implementing such programmes in rural areas can also support midwives and healthcare providers by improving patient engagement, facilitating education, and reducing barriers to early detection. These findings highlight the potential of audiovisual interventions as practical public health strategies…
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Effect of sodium-glucose cotransporter type 2 inhibitors on the course of heart failure in patients with amyloid cardiomyopathy: Results of a pilot single-center randomized trial
CONCLUSION: The administration of SGLT-2 inhibitors to patients with CHF due to ACM leads to an improvement in quality of life, a decrease in the frequency of hospitalizations due to decompensated heart failure of CHF, but does not affect mortality. Further study of therapeutic efficacy in more patients is needed.
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Longevity of different in-office treatments for dentin hypersensitivity: A 6-month randomized and parallel clinical trial
This longitudinal, randomized, parallel-design clinical trial aimed to evaluate the long-term effectiveness of different in-office treatments for dentin hypersensitivity (DH) over a 6-month period. A total of 192 teeth presenting DH associated with root surface exposure were treated with one of four desensitizing agents: fluoride varnish (Duraphat — FLU, active control), bioactive ceramic solution (Biosilicate…
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Adjuvant Pembrolizumab for Stage IIB or IIC Melanoma: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this secondary analysis of a randomized clinical trial, the incidence of new primary melanoma was not different between groups, whereas nonmelanoma skin cancers were more common with placebo. The RFS benefit of pembrolizumab remained after accounting for new primary melanomas. Immune-mediated severe skin reactions occurred infrequently and were manageable. These findings…
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Indirect treatment comparison of DVRd plus DR maintenance (PERSEUS study) versus DVTd or VTd with or without lenalidomide maintenance in transplant-eligible patients with previously untreated multiple myeloma
CONCLUSIONS: Findings from this study suggest that DVRd followed by DR maintenance offers superior survival outcomes compared with current standards of care in TE patients with NDMM.
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Participant Experiences of Therapeutic Touch in Psilocybin-Assisted Therapy
CONCLUSIONS: Therapeutic touch may support emotional safety and affect regulation during acute psychedelic states. Findings highlight the importance of explicit preparation, consent, and attunement when incorporating touch into psychedelic therapy. Further research should inform therapist training, individualized consent frameworks, and safety protocols to guide ethical and effective use in clinical practice.
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Improvements in quality-of-life dimensions through medium-chain triglyceride (MCT) supplementation in rheumatoid arthritis: updated findings from a randomised clinical trial
CONCLUSIONS: Patients with RA supplemented with MCTs obtained significant improvements in several health-related QOL components compared to control, and fibre inclusion did not interfere with MCT efficacy. These results underscore the importance of targeted non-pharmacological approaches integrated to drug therapy in managing patients with RA.
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The BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers
BACKGROUNDChronic graft-versus-host disease (cGVHD) is a major contributor to nonrelapse mortality (NRM) following hematopoietic cell transplantation (HCT). Whether machine-learning (ML) models with biomarkers improve the accuracy for predicting future cGVHD/NRM is not established.METHODSWe developed BIOPREVENT (BIOmarkers PREVENTion), a ML algorithm using data from 1,310 HCT recipients, incorporating 7 plasma proteins measured at Day 90/100 post-HCT…