Clinical Trials
Category Added in a WPeMatico Campaign
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Effectiveness of Al-Assisted Patient Health Education Using Voice Cloning and ChatGPT: Prospective Randomized Controlled Trial
CONCLUSIONS: The innovative patient education model integrating AI voice cloning and ChatGPT is distinct from previous studies primarily relying on standard text-to-speech or professionally recorded content. Using patients’ own cloned voices for health education delivery leveraged the self-reference effect to enhance learning outcomes. Compared with research using clinician-narrated content, this study highlights that self-voice education…
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Home-Based Digital Exercise Program for Patients After Open Repair of Acute Achilles Tendon Rupture: Noninferiority Randomized Controlled Trial
CONCLUSIONS: The home-based DEP following Achilles tendon repair provided comparable clinical outcomes to traditional physiotherapy while significantly improving cost-effectiveness. These findings support the broader adoption of tele-supervised digital rehabilitation as a safe and effective alternative.
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Supportive care: Comparing exercise interventions for upper extremity polyneuropathy induced by chemo- or immunotherapy — VISCIPH B
CONCLUSION: The VISCIPH B pilot trial confirmed the feasibility, safety, and acceptance of supervised exercise for upper-extremity PNP in cancer patients. Significant improvements in patient-reported and functional outcomes indicate that combined sensorimotor and vibration exercise can meaningfully reduce PNP symptoms and should be evaluated in larger trials.
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Efficacy of an artificial intelligence system for lesion detection and characterization (CADe and CADx) during colonoscopy following positive faecal immunochemical test in a colorectal cancer screening programme: A randomized clinical trial
CONCLUSION: In FIT-positive diagnostic colonoscopies with high baseline ADRs, AI assistance did not significantly improve lesion detection. Its primary utility lies in optimizing optical characterization by increasing specificity and PPV, suggesting a potential role in reducing false positives. Further multicentre studies incorporating cost-effectiveness analyses are warranted (ClinicalTrials.gov NCT07125300).
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Transradial vs Transfemoral Access for Cerebral Angiography: A Randomized Noninferiority Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of patients undergoing diagnostic cerebral angiography, TRA was not shown to be noninferior to TFA with regard to the success rate of diagnostic cerebral angiography. Additional research, including superiority trials, is needed to clearly define the comparative benefits of TRA and TFA.
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Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial
CONCLUSION: Multi-strain probiotic supplementation did not enhance the metabolic efficacy of metformin in women with elevated HOMA-IR but significantly alleviated GI side effects. Probiotic co-administration may therefore improve tolerability and adherence to metformin therapy.
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A controlled trial comparing dosimetry and radiation pneumonitis between tomotherapy and IMRT in patients with lung or esophageal cancer
CONCLUSIONS: Compared with fixed-field IMRT, HT provided superior dose distribution to the PTVs while maintaining a comparable incidence of RP in patients undergoing thoracic radiotherapy.
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Implementing a successful patient navigation program for follow-up colonoscopy: Lessons from the PRECISE study
CONCLUSION: Our findings can guide future efforts to implement and sustain patient navigation programs for follow-up colonoscopy after abnormal FIT testing in community-based settings.
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Noninvasive brain stimulation of the left frontal eye field alters fixational control but leaves visually guided saccades unchanged
CONCLUSIONS: Anodal tDCS over the left frontal eye field did not significantly affect gross oculomotor metrics but did modulate fixational saccade dynamics. These findings suggest that miniature eye movements may be more sensitive to neuromodulation than overt saccades, highlighting their potential as biomarkers for cortical excitability. Further research is needed to explore these effects in…
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Smartphone Cardiac Rehabilitation, Assisted Self-Management (SCRAM) Versus Usual Care: Multicenter Randomized Controlled Trial
CONCLUSIONS: This was an underpowered trial, but SCRAM did not lead to a clinically important difference in VO2max compared to usual cardiac care. SCRAM was resilient to COVID-19-related disruptions that significantly impacted the delivery of cardiac rehabilitation and supervised exercise training in particular. Further research is needed to conclusively assess treatment effects and understand how…