Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of a digital tool on breast cancer specific health-related quality of life and psychological distress: secondary results from the ADAPT study
CONCLUSION: The breast cancer digital tool did not have a significant effect on breast cancer-specific HRQoL and psychological distress over time. The results are consistent with the findings of the primary ADAPT paper, which demonstrated that the digital tool did not have a significant effect on patient activation, HRQoL, and health status. There is a…
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Efficacy of Stapled Haemorrhoidopexy vs. Ferguson Haemorrhoidectomy in the Treatment of Haemorrhoidal Disease: A Prospective, Randomised, Single-Blind Comparison
CONCLUSION: SH was equally effective as FH in controlling symptoms associated with HD in the postoperative period and may be recommended as a minimally invasive treatment option for patients.
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Can isokinetic muscle strength training with hip abduction and adduction improve muscle strength, balance, and gait in patients with functional ankle instability? A randomized controlled trial
CONCLUSIONS: Isokinetic strength training through the peri-ankle muscles combined with the hip adductor and abductor muscles was more effective than peri-ankle strength training alone in improving muscle strength, balance, plantar pressure, gait, and self-reported scores in FAI patients.
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Effect of caregiver training on knowledge and confidence of at-home clinical and anthropometric surveillance of children with uncomplicated severe acute malnutrition: analysis of a cross-over cluster randomised trial in Sokoto, Nigeria
INTRODUCTION: Patient-centred task-shifting models may be a promising strategy in the community-based management of severe acute malnutrition (SAM) to alleviate pressure on health systems and increase access to treatment in low-resource settings. The engagement of caregivers in clinical and anthropometric surveillance has not been evaluated.
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Are measures of voice hearing distinct from measures of emotional states, recovery and well-being? A factor analysis study
CONCLUSION: Findings show that measures of voice hearing are distinct from broad outcome measures and therefore are measuring separate concepts. This confirms the psychometric properties of the voice hearing measures and provides some clarity around outcomes and their measurement.
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The effects of intermittent escitalopram treatment on impulsivity and inattention in women with premenstrual irritability and anger
CONCLUSIONS: The finding that escitalopram impacted the outcome of the CPT 3 test in women with premenstrual irritability highlights the possible role of impulsivity in this condition.
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Ferula asafoetida oleo-gum resin alleviates dyspepsia symptoms through modulation of microbiome-gut-brain axis: A randomized, double-blind, placebo-controlled study
CONCLUSION: ASF demonstrated significant modulation of the microbiome-gut-brain axis, resulting in reduced dyspepsia symptom severity, enhanced cognitive performance, improved sleep quality, and better digestive outcomes. These findings support the potential of ASF as a safe and effective dietary supplement for gut and cognitive health in individuals with FD.
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Effectiveness of cold application combined with progressive muscle relaxation in migraine without aura: A randomized controlled trial
CONCLUSION: Both JPMR and JPMR combined with cold application are effective short-term interventions for managing migraine without aura. However, the addition of cold application enhances outcomes in the number of attacks. This combined nonpharmacological approach may be considered as an adjunct strategy for migraine management.
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Comparison of effect of massage or chicory bath on bilirubin levels in term newborns undergoing phototherapy: a randomized clinical trial
CONCLUSION: Based on the results of the present study, Field massage combined with phototherapy was more effective in increasing the frequency of defecation and reducing the length of hospitalization in infants with hyperbilirubinemia compared to those in the chicory bath group and the control group who received phototherapy only.
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Daratumumab plus lenalidomide maintenance in newly diagnosed multiple myeloma after transplant: AURIGA subgroup analyses
In the primary analysis (32.3-month median follow-up) of the randomized, phase 3 AURIGA study (NCT03901963), daratumumab-lenalidomide (D-R) maintenance significantly improved MRD-negative conversion rates and reduced the risk of disease progression or death by 47% versus R maintenance in anti-CD38 monoclonal antibody-naïve and post-transplant MRD-positive patients with newly diagnosed MM. Here, we present a post hoc…