Clinical Trials
Category Added in a WPeMatico Campaign
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Protocol for evaluating the effects of the intelligent multimodal symptom assessment and response system in patients with pemphigus vulgaris: a randomised controlled trial
INTRODUCTION: Pemphigus vulgaris is a rare autoimmune blistering disease characterised by recurrent mucocutaneous erosions, high symptom burden and unpredictable relapse. Current management relies mainly on pharmacological therapy and hospital-based follow-up, with limited real-time monitoring and individualised support in home-based disease management. To address these challenges, this trial aims to evaluate the effectiveness of an Intelligent…
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Pentoxifylline in children with acute encephalitis syndrome: a randomized control trial
Because of the excessive endogenous inflammatory mediators, acute encephalitis syndrome (AES) results in death, or sequelae in survivors. Pentoxifylline, a modulator of inflammation, can have beneficial role in AES. The primary objective was to assess the efficacy of pentoxifylline in terms of time taken for improvement in Glasgow coma scale (GCS) from baseline, in children…
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Quantifying the Phoenix Sign: A Double-Blind Pilot Study on Lidocaine and Papaverine-Induced Vascular and Motor Changes After Common Peroneal Nerve Block in Diabetic Neuropathy
CONCLUSIONS: Peripheral nerve blocks with lidocaine or papaverine improved motor strength and macrovascular function in patients with diabetic peripheral neuropathy, though microvascular changes were not detected. These preliminary findings are consistent with the Phoenix Sign phenomenon and support further study as a potential clinical indicator. While these preliminary findings indicate support as a diagnostic tool,…
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The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial
Background: The plant Griffonia simplicifolia is marketed as a dietary supplement; it is said to have antidepressant and sleep-promoting properties. Its main ingredient, 5-hydroxytryptophan (5-HTP), is the immediate precursor of serotonin and crosses the blood-brain barrier, thereby enhancing central serotonergic neurotransmission. Reduced serotonergic activity has been associated with affective disorders, sleep disturbances, and impaired central…
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Equity Evaluation of an Intervention to Increase Colorectal Cancer Screening at Federally Qualified Health Centers
Racially and ethnically minoritized patients are underscreened for colorectal cancer (CRC), resulting in racial/ethnic disparities. This secondary analysis of a pragmatic patient-randomized clinical trial compared effects of a CRC intervention across race/ethnicity. The multicomponent intervention included a mailed fecal immunochemical test (FIT) for patients in Federally Qualified Health Centers due for screening, plus patient navigation…
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Prayer for Pain and Anxiety in a Primary Care Setting: A Randomized Controlled Trial
CONCLUSION: Proximal intercessory prayer was safe, effective, and well-received as complementary treatment for pain and anxiety. Further studies are warranted. Proximal intercessory prayer may be a low-cost, non-pharmacologic, effective adjunct to standard care with particular relevance for underserved populations.
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Effectiveness of an anti-inflammatory diet intervention and cognitive behavioural therapy in endometriosis: protocol for a randomised controlled clinical trial
INTRODUCTION: Treatment for women with endometriosis is only partially or temporarily effective. Moreover, medical hormonal treatment is associated with debilitating side effects and interferes with fertility, while surgery has a relatively high risk of complications. Meanwhile, women with endometriosis show increasing interest in implementing lifestyle interventions to alleviate symptoms and improve health-related quality of life…
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Digital Cognitive Behavioral Therapy for Insomnia Versus Sleep Hygiene Education for Prevention of Perinatal Depression: Protocol for a Randomized Clinical Trial
CONCLUSIONS: If study hypotheses are supported, then this project will provide a new, scalable approach for preventing perinatal depression.
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Virtual Reality-Based Training in Radiologic Technology for Contrast-Enhanced Computed Tomography Brain Imaging: Randomized Controlled Trial
CONCLUSIONS: The RTVR framework, which uses a real 360-degree video of authentic clinical settings, offers a scalable approach to procedural VR content creation without requiring specialist technical skills, distinguishing it from prior VR studies in radiography. These findings support the RTVR framework as a feasible, evidence-informed supplement to RT curricula for knowledge-focused procedural teaching, with…
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Individualized cognitive-behavioral therapy improves anxiety, depression, sleep quality, hopelessness, and disease severity in fibromyalgia syndrome: a single-blind randomized controlled trial
The current study evaluates the effects of individualized cognitive-behavioral therapy (CBT), administered alongside routine treatment, on anxiety, depression, sleep quality, hopelessness, and disease severity in patients with fibromyalgia syndrome (FMS). This is a randomized, controlled, single-blind clinical trial was conducted in a tertiary physical therapy and rehabilitation clinic. Seventy patients who met the 2016 American…