Clinical Trials
Category Added in a WPeMatico Campaign
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Combined prognostic impact of initial clinical stage and residual cancer burden after neoadjuvant systemic therapy in triple-negative and HER2-positive breast cancer: an analysis of the I-SPY2 randomized clinical trial
CONCLUSIONS: Tumor size at diagnosis remained an independent prognostic factor in patients with TNBC and HER2-positive breast cancer with RD after NAST. In contrast, patients achieving pCR had excellent outcomes regardless of initial disease extent, supporting the relevance of pCR as a surrogate endpoint in breast cancer.
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Ultrasound Measurement of Pupillary Dilation Reflex During Induction of General Anesthesia Using Sufentanil: A Randomized Controlled Trial
BACKGROUND Monitoring nociception is extraordinarily challenging during general anesthesia. This study aimed to observe pupillary dilation reflex by ultrasound and determine whether ultrasonic pupillary parameters are correlated with sufentanil dose during the induction period of general anesthesia. MATERIAL AND METHODS We enrolled 93 patients undergoing general anesthesia. They were randomly divided into 3 groups -…
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Programmed death-1 inhibition increases vaccine-induced T-cell infiltration in patients with prostate cancer
CONCLUSION: Neoadjuvant PROSTVAC in combination with nivolumab is associated with increased intratumoral T-cell infiltrates, increased circulating tumor-associated antigen-specific T cells, and with radiographic and biochemical responses in the mCRPC setting. Our findings support the idea that the addition of a vaccine to a tumor-associated antigen might improve the clinical activity of immune checkpoint inhibition.
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Effects of combined diet and physical activity on glycemic control and body composition in male recreational athletes with type 2 diabetes mellitus
CONCLUSION: A combined therapeutic diet and physical activity program effectively improved body composition and biochemical parameters in recreational athletes with T2DM. This combined approach could be recommended as an integral strategy for diabetes management in physically active individuals.
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The role of compounded mouthwash with or without acyclovir in managing chemotherapy-induced oral mucositis in cancer patients: a randomized controlled trial
CONCLUSIONS: The incorporation of acyclovir into compounded mouthwash significantly reduced the incidence, severity, and duration of oral mucositis in patients undergoing chemotherapy, indicating its potential for expanded clinical application. Further large-scale studies are warranted to validate these findings and to standardize mouthwash formulations for institutional utilization.
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Efficacy of losartan plus modified FOLFIRINOX versus modified FOLFIRINOX in advanced pancreatic cancers: A randomized clinical trial (AFPAC Study)
CONCLUSIONS: The addition of losartan to mFOLFIRINOX in the AFPAC study did not provide an early signal of efficacy in improving progression-free survival in advanced PDAC. The trial will not proceed to full accrual of phase 3 design.
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Evaluating Group CBT for Depression in Newly Diagnosed Breast Cancer Patients in a Malaysian Public Hospital
CONCLUSION: G-CBT significantly reduced depressive symptoms in newly diagnosed breast cancer patients and the effect of intervention sustains until third month follow-up. These findings emphasize the value of incorporating G-CBT into standard care practices to provide targeted psychological support and improve mental health outcomes in this vulnerable population.
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Effects of scalable, wordless, short, animated storytelling videos on hope in China: a nationwide, single-blind, parallel-group, randomised controlled trial
CONCLUSIONS: While the short, single-exposure SAS videos did not significantly enhance overall hope levels among Chinese adults, the effectiveness of humour in certain subgroups highlights the cultural adaptability of health communication strategies. Given its scalability and accessibility, this approach warrants further research to refine narrative techniques, optimise engagement across diverse populations, and explore its broader…
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Cuff leak test and airway obstruction in mechanically ventilated ICU patients (COSMIC): a pilot feasibility randomized controlled trial protocol
INTRODUCTION: The cuff leak test (CLT) is hypothesised to help optimise extubation by assessing for laryngeal oedema which, if unrecognised and untreated, could lead to post-extubation stridor, post-extubation airway obstruction, and reintubation. However, the diagnostic accuracy of the CLT to detect post-extubation stridor (and hence potentially airway obstruction) remains uncertain. Given the equipoise that exists…
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Cost-Effectiveness of an Interdisciplinary, Internet-Based Transgender Health Care Program in Germany: Economic Evaluation Alongside a Randomized Controlled Trial
CONCLUSIONS: From a societal perspective, i²TransHealth was unlikely to be cost-effective, even at high WTP per additional QALY. However, the comparison of i²TransHealth with a waiting list could have led to a distortion of the results with regard to health care service usage. When considering additional reliable improvement on the BSI-18 GSI as health effect…