Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of race and sex on lupus diagnosis in primary care: A randomized factorial survey study
CONCLUSION: A patient’s race and sex may influence diagnostic accuracy and clinical decision-making for SLE in primary care. The observed variation in diagnostic accuracy, which aligns with the descriptive epidemiology of SLE, highlights the need for targeted interventions to ensure equitable diagnostic processes.
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Randomized controlled trial on the effects of different antibiotic regimens in preterm premature rupture of membranes after 34 weeks
CONCLUSION: The 2 different antibiotic regimens administered to pregnant women diagnosed with PPROM after the 34th week of gestation demonstrated similar clinical effects in terms of maternal and neonatal outcomes. Although the differences in NICU stay duration and the number of chorioamnionitis cases were not statistically significant, we believe that these findings could reach significance…
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Feasibility of an Indigenous Food Is Medicine Program for Patients With Heart Failure in Rural Navajo Nation: The MUTTON-HF Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this nonrandomized clinical trial, the MUTTON-HF intervention incorporating Indigenous recipes and locally sourced Native food was feasible and acceptable for patients with heart failure in rural Navajo Nation. These findings will inform a future randomized clinical trial to evaluate the effectiveness of this intervention to advance Indigenous cardiovascular health and food…
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Remimazolam vs. midazolam sedation in upper gastrointestinal endoscopy in adults 65 years: Randomized controlled trial
CONCLUSIONS: In performing upper gastrointestinal endoscopy in older patients, remimazolam can be a good alternative sedative to midazolam, whether used as monotherapy or in combination therapy.
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Effectiveness of flipped classroom on module of severe acute malnutrition among undergraduate students: A randomized controlled study
Background Flipped classroom (FC) teaching is a distinctive method in which a reversal occurs between lecture and homework components. This model differs entirely from traditional classroom teaching and data regarding its effectiveness are sparse. Our primary objective was to evaluate the improvement in post-session test scores and self-acquired confidence between the FC and traditional lecture-based…
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Pharmacokinetic Modeling of Ticagrelor and Ticagrelor Active Metabolite Removal by the DrugSorb-ATR Device in a Randomized Controlled Study of Patients Undergoing Cardiac Surgery
Excessive surgical bleeding is a potential risk in patients taking ticagrelor who must undergo urgent cardiothoracic (CT) surgery before adequate washout of the drug can occur. The DrugSorb-Antithrombotic removal (ATR) device is a polymer sorbent-filled hemoadsorption cartridge that can remove unbound (active) fractions of ticagrelor and ticagrelor active metabolite (TAM) from blood. STAR-T was a…
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Efficacy and Safety of Clascoterone Cream 1% for Acne Are Independent of Age and Sex
Acne vulgaris is an inflammatory skin condition affecting adolescents and adults of both sexes. Clascoterone cream 1% is indicated for the topical treatment of acne vulgaris in patients ≥12 years of age based on the results of two Phase 3 trials (NCT02608450 and NCT02608476). This post hoc analysis evaluated the efficacy and safety of clascoterone…
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The effects of a mobile application-based dementia care intelligent recommender system on caregivers of people with dementia: a randomized controlled trial
CONCLUSION: In summary, this RCT showed that the DCIRS may reduce caregivers’ distress related to care problems and lessen caregiver burden. Although depressive symptoms did not improve significantly, further research is needed to assess long-term effects and clarify the mechanisms underlying remote, personalized interventions such as the DCIRS.
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Functional capacity and quality of life after telerehabilitation in post-tuberculosis lung disease: a randomized controlled trial
CONCLUSIONS: Our findings suggest that telerehabilitation is an effective approach for enhancing physical function and QoL in patients with PTLD.
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Probiotic Supplementation Reduces RRTIs and Enhances Gut Microbial and Immunity in Children: A Randomized Controlled Trial
Recurrent respiratory tract infections (RRTIs) are a major cause of morbidity in children, and strain-defined probiotics have been proposed as a supportive preventive strategy, although clinical evidence remains limited. In this randomized, double-blind, placebo-controlled trial, 120 children diagnosed with RRTIs received either Bifidobacterium animalis subsp. lactis XLTG11 and Lactiplantibacillus plantarum CCFM8661 or a matched placebo…