Clinical Trials
Category Added in a WPeMatico Campaign
-
Cost-Effectiveness of Individualized Occupational Therapy for Inpatients With Schizophrenia: Two-Year Follow-Up of a Multicenter Randomized Controlled Trial
CONCLUSIONS AND RELEVANCE: IOT+GOT was more cost-effective than GOT alone over 2 yr, supporting its wider adoption as an economically sound rehabilitation strategy for clients with schizophrenia. Given the extent of missing cost data, the results should be interpreted with appropriate caution. These findings offer long-term economic evidence to inform mental health policies and resource…
-
Furosemide stress test predicts discontinuation of continuous renal replacement treatments in critically ill patients with acute kidney injury: a prospective multicenter trial
ChiCTR2400091040.
-
Clinical Decision Support for Chronic Kidney Disease in Primary Care: A Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this cluster randomized trial of a CDSS for CKD in primary care, both the intervention and control groups demonstrated comparable improvements in 6-month outcomes, with no independent effect of the CDSS detected.
-
TACE plus lenvatinib and envafolimab for conversion therapy in unresectable HCC: a prospective pilot study
CONCLUSION: In this small pilot study, TACE combined with lenvatinib and envafolimab was associated with encouraging antitumor activity and a relatively high conversion-to-resection rate, with an acceptable safety profile. However, the limited sample size and single-arm design preclude definitive causal conclusions, and gastrointestinal bleeding emerged as an important risk. These preliminary findings suggest the need…
-
A Comparative Analysis of Parent-Reported Treatment Acceptability in Collaborative and Proactive Solutions and Parent Management Training for Oppositional Youth
Evaluating treatment acceptability is crucial, as higher acceptability is associated with better adherence and lower dropout rates, a particular concern in treating youth with disruptive behavior disorders. This study built upon previous randomized controlled trials that demonstrated the efficacy of treatment for youth with oppositional defiant disorder (ODD) by comparing the acceptability of Collaborative and…
-
Written Exposure Therapy for Posttraumatic Stress Disorder and Integration of a Mindfulness-Based App in China: A Pilot Randomized Controlled Trial
Despite posttraumatic stress disorder’s (PTSD) significant burden in China, accessible and effective treatments remain limited. This pilot randomized controlled trial examined the feasibility, acceptability, and preliminary efficacy of Written Exposure Therapy (WET) for PTSD in China and explored whether adding a mindfulness-based app (MBA) improved insomnia outcomes. Forty-six adults meeting Diagnostic and Statistical Manual of…
-
A Randomized Controlled Trial Comparing Transdiagnostic Behavior Therapy and Disorder-Specific Psychotherapies in Veterans With Emotional Disorders
Transdiagnostic psychotherapies have been gaining in popularity due in part to their hypothesized ability to address multiple emotional disorders via a single protocol. However, to date, most randomized clinical trials of these treatments have focused on patients with anxiety disorders, or in mixed samples, limiting their use in other diagnoses. The present study compared Transdiagnostic…
-
Examining the Influence of Social Network Factors on Weight Loss Among Latina and Non-Hispanic White Breast Cancer Survivors: Observational Cohort Study
CONCLUSIONS: Latina and non-Hispanic White participants did not differ in weight loss. However, our findings regarding social network involvement and change in BMI show the importance of considering social network processes in weight loss among breast cancer survivors. These findings buttress existing research suggesting the benefits of social support, particularly within specific cultural frameworks, while…
-
Efficacy and safety of denosumab, zoledronic acid and alendronate on bone mineral density and trabecular bone score in men with osteoporosis
CONCLUSION: Denosumab, alendronate and zoledronic acid significantly and similarly reduced BTMs, increased BMD and TBS in men with osteoporosis, whether the gonadal function of patients was normal or decreased. Previous anti-bone resorption therapy may partially diminish the efficacy of denosumab.
-
A hybrid type 1 trial of a digital behaviour change intervention for frailty prevention in community-dwelling older adults aged 60 years and older
CONCLUSION: A DBCI promoting the adoption of AVOID behaviours among nonfrail, community-dwelling older people is effective in preventing frailty and improving QoL when implemented. Solving technical barriers and incorporating intelligent technologies could enhance impact.