Clinical Trials
Category Added in a WPeMatico Campaign
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Tripartite strategy for dual reduction of radiation and iodine dose in obese CCTA: High-iodine contrast, 80 kVp, and deep learning reconstruction
Coronary CT angiography (CCTA) in obese patients is challenging due to high radiation exposure, elevated iodine load, and increased image noise. We evaluated a tripartite low-dose strategy combining high-iodine-concentration contrast media (HCM, 400 mgI/mL), 80-kVp scanning, and deep learning image reconstruction (DLIR) in obese patients (BMI ≥30 kg/m2) to simultaneously reduce radiation and iodine dose…
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Effects of psycho-cardiology care on psychological and clinical outcomes among primary aldosteronism patients undergoing adrenal vein sampling: A randomized controlled study
Adrenal vein sampling (AVS) is considered the gold standard for the subtyping diagnosis of primary aldosteronism (PA), which is essential for preventing adverse cardiovascular outcomes. Nevertheless, the AVS procedure might induce anxiety in patients with PA because of discomfort and the uncertainty of the outcome. Therefore, this study aimed to assess the effectiveness of psycho-cardiology…
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Clinical application of Chester Step Test in developing personalized exercise prescription in patients with type 2 diabetes: A single-blind, randomized controlled trial
CONCLUSIONS: Under free-living conditions, the personalized exercise prescription based on CST effectively reduced glycemic variability in T2D patients.
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An extended cost-effectiveness analysis of decentralised TB diagnostic testing with Molbio Truenat MTB/RIF versus hub-and-spoke GeneXpert MTB/RIF in Mozambique and Tanzania
CONCLUSION: The intervention reduced patient costs and improved outcomes across SES groups. Decentralised TB testing with the Molbio Truenat platform is both cost-saving and more effective and cost-effective compared with a hub-and-spoke model in Mozambique and Tanzania.
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Mobile App-Guided Exposure Therapy for Panic Disorder With and Without Agoraphobia: Randomized Controlled Trial
CONCLUSIONS: Our findings suggest that app-guided exposure therapy can be a useful further treatment option in addition to established psychological and pharmacological strategies. However, superiority compared to the disorder-unspecific meditation app remains unclear.
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Concentration-QTc Analysis of Valemetostat in Patients With Hematologic Malignancies
This study assessed the potential risk of QT prolongation associated with the dual enhancer of zeste homolog 1/2 inhibitor valemetostat. An evaluation of the relationship between plasma valemetostat concentration and heart-rate-corrected QT (QTc) interval was performed. Time-matched plasma concentration and 12-lead electrocardiogram data were collected from the phase I studies DS3201-A-J101, in patients with relapsed/refractory…
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Application of the theory of planned behavior in self-care behaviors of knee osteoarthritis in the rural older people
CONCLUSION: The results showed that the use of TPB contributed to the improvement of self-care for knee osteoarthritis in older people. Due to the importance of health education in promoting self-care behaviors and preventing complications, longer interventions with the aim of preventing the complications of knee osteoarthritis in older people are suggested.
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Integrating augmented reality into health media campaigns: toward a more behavioral impact economic evaluation
This study investigates the efficacy and economic efficiency of augmented-reality (AR)-enhanced health-media campaigns in urban settings of Jordan, the Saudi Arabia. Employing a quasi-experimental, comparative design, 600 adults aged 18-45 were randomly assigned to either an AR intervention-featuring interactive 3D simulations of smoking risks and vaccination mechanisms-or a conventional video/text campaign. Pre- and post-intervention surveys…
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Impact of TauroLock™-HEP500 versus unfractionated heparin for prevention of catheter complications in children with malignancy: a prospective, randomized, controlled study
CONCLUSION: Taurolidine-citrate exhibited a modest anti-inflammatory effect, reflected by reduced hs-CRP and WBC levels, without significant improvement in catheter-related complications or IL-6. The lack of major clinical benefit may relate to the heterogeneous and immunocompromised nature of pediatric oncology patients. Larger, adequately powered studies are warranted to clarify the long-term efficacy and safety of taurolidine-citrate…
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Results of the observational program CITOTREK (use of the drug CITOflavin in Tablets) in patients with tension headaches against the backgRound of asthenic syndromE taKing into account comorbidity
CONCLUSION: The results of the study allow us to consider the drug Cytoflavin in the treatment regimens for comorbid patients with TTH in asthenic disorders.