Clinical Trials
Category Added in a WPeMatico Campaign
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The Impact of Endoscopic Ultrasound and Multidisciplinary Team Evaluation on the Management of Pancreatic Cystic Lesions
CONCLUSION: While susceptible to cognitive bias, EUS significantly improves MDT assessment of PCL. MDT establishes a high bar for iterative additions of biomarkers to PCL analysis.
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Effect of the online Rethink My Drink alcohol intervention on alcohol use and cognition in older adults in Australia: a randomised controlled trial
BACKGROUND: Alcohol use is increasing among older adults and is associated with cognitive impairment and dementia. The efficacy of scalable approaches to reduce alcohol use and related harms in older adults has not been tested. This study aimed to evaluate the efficacy of an online alcohol intervention in reducing alcohol use and cognitive decline in…
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Efficacy of a simplified photobiomodulation protocol in orthodontic patients: a randomized crossover clinical trial
CONCLUSION: The study shows that photobiomodulation can help control orthodontic pain, being well accepted by participants and not extending clinical time. However, the analgesic effects are still limited, indicating the need to refine the protocol to enhance its effectiveness.
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The impact of muscle energy technique and aromatherapy on pain, disability, and sleep quality in office workers with nonspecific neck pain: randomized controlled study
CONCLUSION: This study provides evidence that both aromatherapy and muscle energy technique are safe and practical treatments, which are efficacious in the reduction of pain, disability, and sleep quality in nonspecific neck pain.
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Topical ROCK inhibition accelerates recovery after Descemetorhexis Without Endothelial Keratoplasty (DWEK) in Fuchs endothelial corneal dystrophy: a prospective comparative clinical trial
CONCLUSIONS: Adjunctive topical ripasudil after DWEK accelerates endothelial recovery, corneal deturgescence, and visual rehabilitation compared with DWEK alone, without compromising safety.
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The journey to diagnosis and care of functional neurological disorder (FND)
CONCLUSION: The findings emphasize the need for personalised and compassionate care for individuals suffering from FND, underpinned by increased service provision within the healthcare system.
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Effects of VIVIFRAIL intervention on multidimensional frailty in older nursing home residents: a randomised-controlled feasibility study
CONCLUSIONS: The VIVIFRAIL exercise program was determined to be feasible for older adults residing in nursing homes and significantly improved frailty status, health indicators, ADLs and QOL. These findings support the incorporation of structured exercise interventions as an essential component of routine care provided by health-care professionals in nursing home settings.
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Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in combination with Yiqi Tonglin Yangyin decoction and antibiotics for treating elderly female patients with complicated urinary tract infection
CONCLUSION: Abdominal moxibustion at the Zhongji (CV3), combined with Yiqi Tonglin Yangyin decoction and antibiotics for treating complicated urinary tract infections in elderly women, can effectively improve the clinical symptoms, TCM syndromes, and immune function of patients. Additionally, it can reduce oxidative stress, promote patient recovery, and lower the recurrence rate with pronounced comprehensive efficacy.
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First-in-Human Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Oral Doses of BIIB091, an Oral BTK Inhibitor, in Healthy Adult Participants
CONCLUSION: BIIB091 was well tolerated at single doses up to 1200 mg and repeated doses up to 300 mg BID, showing dose-linear PK and sustained effective B cell activation suppression. BIIB091 PK appeared to be sensitive to food effect. These important insights support its continued development for MS.
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Impact of body mass index on the efficacy of acupuncture treatment of postprandial distress syndrome: secondary analysis of a randomized clinical trial
CONCLUSION: This subgroup analysis indicated that acupuncture improved PDS symptoms across different BMI categories. Acupuncture was suggested as a viable therapeutic option for patients with PDS, particularly those with a higher BMI.