Clinical Trials
Category Added in a WPeMatico Campaign
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Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial
The present study aims to compare the efficacy and safety of norepinephrine (NE) versus dopamine in achieving early (within 45 min of initiation) reversal of fluid-refractory septic shock in preterm neonates. A double-blind randomized controlled trial was conducted in a Level-III tertiary care hospital in Northern India. Fifty neonates born at a gestational age of…
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Pilot Study of Early Adoption of Automated Insulin Delivery in Underresourced Youth
CONCLUSION: Early initiation of AID is feasible and acceptable in youth with recently diagnosed T1D from underresourced populations who historically experience lower technology adoption and less optimal glycemic outcomes. Diabetes clinicians should consider providing tailored support and dedicated resources to families early in diagnosis with T1D to promote AID initiation and continued use.
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Efficacy and Safety of Methotrexate Administered by Oral and Subcutaneous Routes in Patients with Severe Psoriasis
CONCLUSION: The SC route of MTX administration is safer and more effective than the oral route in patients with severe psoriasis.
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2′-Fucosyllactose supplementation results in a transient improvement in gut microbial resilience after vancomycin use in adults with overweight or obesity: a randomized, double-blind, placebo-controlled intervention
Antibiotic-induced perturbations of the gut microbiome can be long-lasting and potentially affect host metabolic health. Strategies supporting microbial resilience are needed to mitigate the negative impact of antibiotics. We investigated the potential of 2′-fucosyllactose (2′-FL) supplementation after vancomycin use in a double-blind placebo-controlled randomized intervention among adults with overweight/obesity. Participants received oral vancomycin for seven…
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Effect of ketogenic diet plus dulaglutide on glucose and lipid metabolism in diabetes mellitus
Diabetes mellitus is a chronic disease with a high incidence worldwide and exclusive drug treatment has a limited effect. To investigate the effects of a ketogenic diet combined with dulaglutide on glucose and lipid metabolism in diabetic patients, a total of 104 patients with type 2 diabetes mellitus were randomly divided into a study group…
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Financial incentives to improve uptake of partner treatment for sexually transmitted infections in antenatal care: a cluster randomised trial in Zimbabwe
BACKGROUND: Partner treatment is an essential component of sexually transmitted infection (STI) case management. We aimed to compare the uptake of partner treatment for STIs within antenatal care in Zimbabwe, with and without the provision of a financial incentive.
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A qualitative study of Emotion and Symptom-focused Engagement (EASE): An integrated psychotherapeutic and early palliative care intervention for patients with acute leukemia
CONCLUSION: The findings of this study support the acceptability and perceived benefit of EASE-Psy for adults newly diagnosed with AL. The RCT in progress will illuminate the effectiveness of EASE to relieve traumatic stress and physical symptom burden in this population.
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The effects of povidone-ıodine and chlorhexidine gluconate on the ocular surface after phacoemulsification cataract surgery
CONCLUSION: Both PI and CHG caused transient ocular surface changes after cataract surgery. However, CHG demonstrated faster recovery of tear film parameters and improved early postoperative comfort, suggesting it may be a preferable antiseptic in patients with ocular surface sensitivity.
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Clinical and cost-effectiveness of a standardised diagnostic assessment for children and adolescents with emotional difficulties: the STADIA multi-centre RCT
CONCLUSIONS: We found no evidence that completion of the development and well-being assessment aided the detection of emotional disorders in this study. Using the development and well-being assessment in this way cannot be recommended for clinical practice.
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Procedural characteristics and clinical outcomes from same-day discharge after pulsed field ablation treatment for atrial fibrillation: an admIRE trial sub-analysis
CONCLUSION: SDD is feasible in a paroxysmal AF population undergoing PFA with the VLCC, demonstrating comparable safety and effectiveness outcomes with overnight hospitalization.