Clinical Trials
Category Added in a WPeMatico Campaign
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Diagnostic and Prognostic Performance of Pericoronary Adipose Tissue Attenuation in Suspected Acute Coronary Syndrome: Insights from the RAPID-CTCA Trial
Purpose To assess whether pericoronary adipose tissue (PCAT) attenuation on coronary CT angiography (CCTA) aids in the diagnosis of acute coronary syndrome (ACS) or provides additive prognostic value at 1 year in intermediate-risk individuals. Materials and Methods This study was a secondary post hoc analysis of the multicenter prospective randomized Rapid Assessment of Potential Ischemic…
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Edaravone dexborneol versus placebo on functional outcomes in patients with acute ischaemic stroke undergoing endovascular thrombectomy (TASTE-2): randomised controlled trial
CONCLUSIONS: Among patients with acute ischaemic stroke within 24 hours of symptom onset who underwent endovascular thrombectomy, those treated with edaravone dexborneol, compared with placebo, were more likely to achieve functional independence at 90 days without increased safety concerns. This effect seemed to be primarily driven by the subgroup with mismatch present at admission, suggesting…
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Effect of combining lower- and higher-value monthly cash transfers with nutrition-sensitive agriculture, male engagement and psychosocial intervention on maternal depressive symptoms in rural Malawi: a secondary analysis of a cluster-randomised controlled trial
Maternal depression affects one in five women in Malawi. Integrated interventions simultaneously addressing multiple risks are a promising strategy to improve mental health. This study evaluated the impact of a nutrition-sensitive social behaviour change (SBC) intervention (agriculture and livelihoods, male engagement and Caring for the Caregiver) with or without cash transfers on maternal perinatal depression…
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Effects of early off-bed activity on respiratory mechanics in intensive care unit patients undergoing mechanical ventilation
CONCLUSIONS: Both conventional progressive early mobilization and early off-bed activity influence respiratory mechanics parameters in ICU patients undergoing mechanical ventilation, but early off-bed activity has a greater impact. Early off-bed activity did not increase airway pressure or cause airway injury. Furthermore, early off-bed activity better shortened the duration of invasive mechanical ventilation and ICU length…
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Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions
Six months of drug treatment is standard of care for drug-sensitive pulmonary tuberculosis (TB). Understanding the factors determining the length of treatment required for durable cure would allow individualization of treatment durations. We conducted a prospective, randomized, controlled noninferiority trial (PredictTB) of 4 versus 6 months of chemotherapy in patients with pulmonary TB in South…
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Impact of exercise sequence in concurrent training on insulin resistance, glycemic control, and blood pressure in Type 2 diabetes
This study compared the effects of aerobic followed by resistance (CART) and resistance followed by aerobic (CRAT) training on insulin sensitivity, glycemic control, and blood pressure against a non-exercising control group (COT). 39 patients with type 2 diabetes were randomly assigned to CART (n = 13), CRAT (n = 13), or COT (n = 13)…
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Interrelationship Between Patient and Family Caregiver Outcomes Following Lung Cancer Surgery: A Secondary Analysis of a Randomized Controlled Trial
CONCLUSIONS: The results of this study support the interdependent, bi-directional associations of patient and caregiver well-being. Further multi-media interventions in the peri-operative period focused on self-efficacy and promoting emotional resilience among caregivers may substantially improve post-operative outcomes for both members of the dyad.
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Effects of a Digital Multidomain Cognitive Intervention in Older People at High Risk of Dementia: A Randomized Clinical Trial
Objective: To evaluate the effects of a 6-month digital multidomain cognitive intervention on cognitive function and psychosocial outcomes in older adults at high risk of dementia.
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Results of treating patients with diabetic foot ulcers with hyperbaric oxygen
CONCLUSIONS: Hyperbaric oxygens a good method for treating diabetic foot ulcers, helps with anti-inflammation, stimulates the growth of granulation tissue, quickly heals ulcers, reduces treatment time, and reduces amputation rates.
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Randomised, double-masked trial to compare the efficacy, safety and immunogenicity of the biosimilar aflibercept FYB203 with reference aflibercept in patients with neovascular age-related macular degeneration
CONCLUSION: Although conducted during the COVID-19 pandemic in a potentially vulnerable elderly population and affected by geopolitical disruption in Ukraine, mitigation measures minimised the overall impact of these events. FYB203 demonstrated therapeutic equivalence to reference aflibercept in patients with nAMD, supporting similar clinical performance across all approved indications.