Clinical Trials
Category Added in a WPeMatico Campaign
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Economic evaluation of a multi-component obesity prevention intervention in Chinese primary schools
CONCLUSIONS: The DECIDE-Children intervention is a cost-effective strategy for childhood obesity prevention, providing significant public health and economic benefits. Its integration of school, family, and digital components offers a scalable, sustainable model for addressing childhood obesity in China and other developing settings.
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Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD: a randomised controlled trial
CONCLUSIONS: Kefir supplementation may support modest improvements in sleep quality, in children with ADHD. These findings contribute to our understanding of the potential role of nutrition in ADHD management and may inform clinical guidance for practitioners working with neurodivergent individuals.
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Clinical efficacy of integrated 3D manual pelvic reduction, suspension training, and pelvic belt fixation for postpartum pubic symphysis diastasis
CONCLUSION: The combined protocol of 3D pelvic reduction, suspension training, and pelvic belt fixation effectively alleviates pain, restores pelvic alignment, enhances functional recovery, and improves QoL in postpartum PSD patients, representing a potentially promising therapeutic strategy for clinical adoption.
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Effect of azithromycin on post-discharge growth in Kenyan children
CONCLUSION: We did not observe statistically significant improvements in post-discharge growth among children receiving azithromycin at hospital discharge.
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Esketamine prevents postoperative sleep disturbance in patients with preoperative sleep disorders: a role for oral microbiota
Patients with preexisting sleep disorders face a significantly increased risk of postoperative sleep disturbance (PSD) due to heightened sensitivity to surgical stress, anesthesia, and hospital-related environmental factors. There is a critical unmet need for effective prophylactic medications to prevent PSD, as current treatment options are limited and often inadequate. This study investigated the prophylactic effect…
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Preventing depression in Chinese children and adolescents: A pilot study of a brief school-based cognitive behavioral group program
CONCLUSION: Power Up-CBTD demonstrated reasonable feasibility and acceptability, showing promising preliminary effects in reducing depressive symptoms among school-aged youth in mainland China. Larger randomized trials with extended follow-up are warranted.
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Chatbot-Delivered Real-Time Support to Improve HIV Self-Testing Rates: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the HIVST-chatbot was noninferior to the HIVST-OIC in increasing HIVST uptake and counseling among HIVST users. These results suggest that the HIVST-chatbot might be an alternative to the evidence-based HIVST-OIC service for MSM.
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Effects of combined exercise training for adults with resistant major depression: a pilot study from the TRACE-RMD project
CONCLUSIONS: A supervised combined exercise program in people with RMD may induce positive and beneficial changes in functionality and clinical and QoL variables, and maintain body composition, CRF, and the biochemical profile. These preliminary results highlight the critical role of supervised exercise, regardless of intensity, in improving clinical symptoms in people with RMD. This study…
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A case-control study investigating the impact of gradient pressure therapy on chemotherapy-induced peripheral neuropathy symptoms and daily activities in paclitaxel-treated patients
CONCLUSION: Gradient pressure therapy effectively reduces symptoms of paclitaxel-induced peripheral neuropathy, improving patients’ daily activities. This intervention is recommended for clinical promotion and application.
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Parent-child agreement in reporting somatic distress, gastrointestinal symptoms, mental health, and general health in girls with functional abdominal pain
CONCLUSION: Findings indicated good parent- and child agreement for gastrointestinal and general somatic symptoms, but lower agreement for mental health and general health.