Clinical Trials
Category Added in a WPeMatico Campaign
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Efficacy of Xanthan-Based Chlorhexidine Gel in Peri-Implant Mucositis Treatment: A Split-Mouth Randomized Clinical Trial
CONCLUSION: The adjunctive use of XanCHX gel did not result in any statistically significant clinical benefit compared to PMPR alone in the treatment of PM up to 6 months, despite the reported clinical positive effects within the first month after treatment.
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Quality of Recovery after Open Gynecological Surgery
Introduction: Hysterectomies are one of the most common major open gynecologic surgeries. Open gynecological surgery results in a large wound and severe postoperative pain, and adequate postoperative analgesia is necessary. As part of multimodal analgesia strategies, regional anesthesia techniques are widely used in such surgeries to reduce opioid consumption and enhance analgesic efficacy. Spinal anesthesia,…
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Effectiveness of the Systems Analysis and Improvement Approach to optimise outpatient mental, neurological, and substance-use disorder treatment cascades in Mozambique: a cluster-randomised trial
BACKGROUND: To our knowledge, there are no evidence-based implementation strategies for care cascade optimisation of mental, neurological, and substance use (MNS) disorder treatment in low-income and middle-income countries. This trial evaluated the effectiveness of the Systems Analysis and Improvement Approach for Mental Health (SAIA-MH) implementation strategy to improve MNS disorder care cascade outcomes in Mozambique.
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GRACE score for risk stratification and completeness of revascularization in older patients with myocardial infarction
CONCLUSION: The GRACE score was confirmed to be predictive of adverse outcomes even in older MI patients. Physiology-guided complete revascularization was associated with benefit across the GRACE spectrum, suggesting that the GRACE score alone should not preclude this strategy in older patients with MI.
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Cost-Effectiveness of Oral Immunotherapy Treatments vs No Treatment for Peanut Allergy in Children
CONCLUSIONS AND RELEVANCE: This economic evaluation found that for remission, both PPOIT and OIT were cost-effective and good value compared with no treatment, with OIT associated with a larger effect size but no clinically meaningful difference. When QALYs are prioritized, PPOIT offers the best value. Key factors associated with cost-effectiveness were treatment product pricing and…
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Treatment with inhaled nitric oxide in patients with pulmonary embolism
CONCLUSION: Inhaled NO therapy in complex therapy of PE demonstrated safety and efficacy in relation to clinical, functional and laboratory parameters.
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Predictive value of OGTT parameters and clinical markers in gestational diabetes mellitus: a prospective randomized controlled trial from a tertiary center in Turkiye
CONCLUSION: The one-step 75 g OGTT increases diagnostic labeling without improving short-term clinical outcomes. Post-load OGTT values-particularly 2-hour glucose levels-provide the most clinically meaningful prognostic information and may support a risk-stratified approach to GDM management rather than expansion of diagnostic thresholds alone.
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Effects of Cipepofol on Cardiac Depolarization and Repolarization in Healthy Subjects: A Single-Center, Randomized, Placebo and Positive-Controlled Thorough QT Study
CONCLUSION: Cipepofol exhibited no clinically relevant effects on the QTc interval or other ECG parameters, and was safe and well tolerated in healthy subjects.
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Randomized Controlled Trial of the Meaning-Making Intervention (MMi) in Patients Newly Diagnosed With Advanced Cancer: Full Trial
BACKGROUND: This study aimed to test whether the Meaning-Making intervention (MMi) increases the sense of meaning in life in people newly diagnosed with any type of advanced cancer.
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Cost-effectiveness of proactive therapeutic drug monitoring of maintenance infliximab treatment in patients with immune-mediated inflammatory diseases: results from a randomised controlled trial
CONCLUSION: pTDM is very likely a cost-effective treatment strategy for patients with immune-mediated inflammatory diseases on infliximab maintenance therapy.