Clinical Trials
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Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions
CONCLUSIONS: MCT enhances specific neurocognitive functions in FEP and shows promising effects for women in verbal memory processes. These findings underscore the importance of incorporating sex and diagnostic factors when tailoring early interventions for psychosis and highlight the potential of MCT as a personalized cognitive strategy.
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Cognitive Resilience Training to Prevent PTSD and Major Depressive Disorder in Paramedic Recruits: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, participants receiving iCT-R were approximately 5 times less likely to develop PTSD or MDD at 1-year follow-up compared with psychoeducation and 4 times less likely when compared with standard practice. These findings suggest that iCT-R appears to decrease the likelihood of developing PTSD and MDD in early…
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Efficacy and Safety of Letrozole, Misoprostol and Their Combination in First Trimester Missed Miscarriage: A randomised clinical trial
CONCLUSION: Combining letrozole with misoprostol significantly improves complete miscarriage rates with tolerable safety. Letrozole alone is safer but less effective. Thus, combination therapy may offer an optimal non-surgical strategy for individualised management.
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Improving Delirium Screening and Detection in the Emergency Department (ED): The Implementation and Evaluation of the ED Delirium Detection Program
CONCLUSIONS: Although a comprehensive ED delirium training program successfully increased delirium screening, detection remained low. These findings suggest that sustainable delirium detection in the ED requires not only robust training but also deeply embedded workflow solutions and clear post-detection action pathways.
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Effect of Ultrasound Combined with Microbubbles on Blood Perfusion in Invasive Breast Cancer-A Prospective Clinical Trial
IntroductionBlood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. This study aimed to investigate the effects of ultrasound-stimulated microbubbles (USMBs) on hemoperfusion in invasive breast cancer (IBC).MethodsIn this prospective clinical trial, 36 patients diagnosed with IBC were enrolled sequentially. The…
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Safety and Feasibility of Long-Term High-Intensity Interval Training With and Without Peer Support in Cancer Survivors
Despite the benefits of physical activity and exercise, including high-intensity interval training (HIIT), few cancer survivors meet the exercise oncology guidelines. Emerging evidence suggests peer support (i.e., assistance from individuals with lived experiences trained in behavior change techniques) may improve exercise adherence, yet its long-term safety and feasibility remain unclear. This study evaluates the safety…
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Histopathological Findings of Appendix Specimens in Quiescent Ulcerative Colitis: Correlations With Clinical Outcomes in the ACCURE Trial
CONCLUSION: Active appendiceal inflammation is prevalent in quiescent UC and showed a trend toward association with relapse risk. Although the benefit of appendicectomy in this group cannot be confirmed on these data alone, the finding might be clinically relevant as relapse rates are significantly reduced in the appendicectomy group.
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Safety and Preliminary Clinical Effects of a Herbal Balance Solution in Mild-To-Moderate Acne Vulgaris: An Open-Label, Single-Arm Pilot Study
CONCLUSION: In this open-label pilot study, use of Herbal Balance Solution was associated with short-term improvements in acne-related clinical parameters and skin barrier function and was well tolerated in patients with mild-to-moderate acne vulgaris. These preliminary findings warrant confirmation in randomized, vehicle-controlled clinical trials.
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Perceptions of best practice, pain science and structure-focused education for rotator cuff-related shoulder pain: a content analysis of qualitative data from a randomised experiment
CONCLUSION: Participants with rotator cuff-related shoulder pain expressed generally similar emotional responses across groups, with small differences in treatment preferences favouring self-management in the best practice education groups compared with those who received structure-focused education. Those in the best practice education also less frequently reported needing potentially unnecessary treatments (eg, imaging, injections and surgery).
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Comparison of Disorder-Specific Group CBT and Generic Group CBT in Treating Adolescents with Social Anxiety Disorder: A Randomized Controlled Trial
Social anxiety disorder is one of the most common disorders in adolescence. It is associated with severe distress, negative long-term consequences, and chronicity. Cognitive behavioral treatment (CBT) is the recommended treatment for social anxiety disorder. However, adolescents with social anxiety disorder consistently show poorer outcomes than any other anxiety disorder. The aim of the study…