Clinical Trials
Category Added in a WPeMatico Campaign
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Economic Costs and Benefits of the Digital OurRelationship Program for Distressed Couples
Relationship distress is a prevalent issue with significant economic and societal consequences, including increased mental and physical health problems, decreased workplace productivity, and increased absences. Although couple therapy has been shown to improve relationship and individual well-being, its high costs limit accessibility. Digital relationship interventions provide a cost-effective alternative. However, limited research has assessed the…
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Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial
CONCLUSIONS: In nulliparous PRIME trial participants, IGFBP4/SHBG screen-guided care reduced composite neonatal morbidity and NICU admissions compared to routine care. These findings support the clinical utility of biomarker-guided preventive strategies in first-time pregnancies lacking prior obstetric history.
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Primary Care Integrated Management of chronic obstructive pulmonary disease (PRIM-COPD): study protocol for a cluster-randomised controlled trial
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, with China bearing a particularly high burden. Major gaps persist in early diagnosis, guideline-based treatment and long-term disease management, especially in primary care. This study aims to evaluate the efficacy and feasibility of the National Essential Public Health Services (NEPHS)…
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Development and Validation of a Computational Histology Artificial Intelligence-Powered Biomarker in Metastatic Hormone-Sensitive Prostate Cancer on Randomized Phase III Trials
CONCLUSION: We developed and validated an image-only AI-based biomarker associated with clinical outcomes and potential benefit from treatment escalation in mHSPC independent of conventional clinicopathologic risk factors.
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Optimizing treatment for depressed parents of children with emotional and behavioral disorders: A multi-site feasibility trial
CONCLUSION: Given that a priori progression criteria were met and we found preliminary indication of efficacy, we conclude that an RCT of ADAPT to determine efficacy is warranted.
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Subliminal Priming Effects on Motor and Cognitive Performance: Pilot Evidence With Implications for Neurorehabilitation
CONCLUSIONS: Subliminal priming produced modest gender-dependent effects on maximal walking speed and reaction time. These preliminary findings indicate selective sensitivity of high-demand motor tasks to subliminal cues, warranting further investigation using larger sample sizes and clinical populations.
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Efficacy and safety of reduced-dose daratumumab plus bortezomib and dexamethasone (DVd-lite) in newly diagnosed MGRS patients
CONCLUSIONS: These findings demonstrated that the DVd-lite regimen is an effective and well-tolerated first-line treatment option for newly diagnosed MGRS patients.
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Hospital-Based Psychosocial Case Management and Suicide Prevention in South Korea: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this RCT of outpatients with MDD and high suicide risk, ACM significantly reduced C-SSRS total scores and psychological distress compared with usual care. These findings provide a critical, high-level evidence base for the national implementation of standardized, hospital-centered psychosocial interventions as a scalable public health strategy for suicide prevention.
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Short-term OCT-based evaluation of corneal epithelial remodeling with two silicone hydrogel bandage contact lenses after t-PRK
CONCLUSIONS: Both bandage contact lens materials demonstrated broadly comparable short-term postoperative epithelial remodeling patterns and refractive outcomes after t-PRK. Minor early regional differences observed on OCT should be interpreted cautiously.
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Cost-effectiveness of immediate septoplasty versus medical management with the option for delayed septoplasty for nasal airways obstruction: a multicentre, open-label, randomised controlled trial
CONCLUSIONS: Over a 24-month time horizon, immediate septoplasty would be cost-effective in the management of deviated nasal septum.