Clinical Trials
Category Added in a WPeMatico Campaign
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Sex-specific predictors of self-stigma reduction in psychosis resulting from metacognitive interventions: Results from a randomized clinical trial
CONCLUSION: Distinct pathways of self-stigma recovery emerged for women and men, underscoring the need for gender-sensitive interventions. These findings underscore the need for tailored stigma-reduction interventions that consider gender-specific factors influencing mental health outcomes. Longitudinal research should assess durability and further clarify gender-related mechanisms.
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Reducing Screen Time in Children With Borderline IQ: A Randomized Controlled Trial of a Parent-Mediated Screen Time Usage Module
Objective: The rapid expansion of mobile technology has significantly altered children’s screen time behaviors, contributing to concerns about excessive usage. These changes are particularly relevant for children with borderline intellectual functioning, in whom unmanaged screen time may exacerbate developmental challenges. This study aimed to evaluate the effectiveness of a parent-mediated screen time usage module (PM-STUM)…
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Safety, Tolerability, Pharmacokinetics, Food Effect of Ribitol, and Its Effect on QTcF in Healthy Adults: First-in-Human, Randomized, Double-Blind (Sponsor Unblinded), Placebo-Controlled Studies
Limb-girdle muscle dystrophy Type R9 (LGMDR9), also known as LGMD Type 2I, is a rare genetic disease caused by partial loss of function of fukutin-related protein (FKRP) enzyme which glycosylates alpha-dystroglycan, thereby stabilizing myocytes during contraction. Hypoglycosylation leads to progressive muscle injury and impaired function including loss of ambulation. Ribitol is an endogenous pentose alcohol…
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Ultrasound-Guided Stellate Ganglion Block in Fibromyalgia: A Randomized, Single-Center, Single-Blind, Sham-Controlled Trial
CONCLUSION: In treatment-resistant fibromyalgia patients receiving stable duloxetine, ultrasound-guided SGB produced clinically meaningful short-term improvements in fibromyalgia impact and pain with an acceptable safety profile. However, the large effect sizes should be interpreted cautiously given potential unblinding and placebo effects. Larger, multicenter trials with longer follow-up, objective outcome measures, and formal blinding assessment are warranted.
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SSGJ-613 Alleviates Pain and Reduces the Risk of Acute Flares in Patients With Gout: A Randomized, Double-Blind, Phase II Study
CONCLUSION: A single injection of SSGJ-613 demonstrated rapid pain relief comparable to corticosteroid therapy at 72 h and provided superior protection against gout flare recurrence over 12 weeks in Chinese patients, supporting its potential as an effective treatment option for acute gouty arthritis with prolonged therapeutic benefits.
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Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial
CONCLUSIONS: The antithrombotic agents evaluated in this trial (aspirin, clopidogrel, and rivaroxaban) were all non-inferior to metoprolol for responder rate in participants with PFO and migraine. Rivaroxaban also showed superior responder rates over metoprolol without an increase in major bleeding events.
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Randomized Controlled Trial on the Effect of Yoga on Anxiety Severity, Quality of Life, and Biomarkers in Individuals with Anxiety Disorder
Anxiety disorders are highly prevalent mental health conditions characterized by physiological dysregulation that includes heightened stress responses, low-grade systemic inflammation, and metabolic imbalance, which together contribute to impaired quality of life. Although yoga-based interventions are increasingly used as complementary therapies, evidence isolating the effects of slow pranayama (yoga breathing) and savasana (corpse pose) on psychological…
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A Phase 1 clinical trial to evaluate the safety and tolerability of CLZ-2002 for the treatment of patients with Charcot-Marie-Tooth disease type 1
CONCLUSIONS: A single intramuscular dose of CLZ-2002 of up to 24 million cells was safe and well-tolerated in CMT1 patients. Exploratory efficacy assessments suggested possible clinical benefit, warranting continued investigation of CLZ-2002 in larger, controlled study populations.
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Client and therapist experiences with the Processing of Positive Memories Technique (PPMT) in a randomized controlled trial: insights for protocol refinement
Background: The Processing of Positive Memories Technique (PPMT) is a brief, memory-based intervention designed to enhance access to detailed positive autobiographical memories (AMs) in individuals with posttraumatic stress disorder (PTSD). Although research suggests that PPMT is feasible and may reduce PTSD symptoms, little is known about client and therapist experiences with PPMT when delivered to…
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Impact of a Staged Enteral Nutrition Nursing Pathway Based on Dynamic Assessment of Tolerance and Aspiration Risk vs Usual Care on Feeding Intolerance in Older Adult Patients With Acute Ischemic Stroke and Dysphagia: A Single-Center Randomized Controlled Trial
BACKGROUND Older adult patients with acute ischemic stroke have dysphagia and require early post-pyloric enteral nutrition, yet feeding intolerance and unstable energy delivery remain common, and practical pathways that integrate tolerance and aspiration risk are lacking. This trial evaluated whether a dual-axis staged nursing pathway, compared with usual care, was associated with lower feeding intolerance…