Clinical Trials
Category Added in a WPeMatico Campaign
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A Randomized Trial to Investigate the Effects of Low-Dose Colchicine in Patients with Hypertension: Rationale and Design of the COlchicine and HypERtENsion Trial (COHERENT)
Hypertension is a prevalent and significant risk factor for cardiovascular disease (CVD). The immune system and inflammatory response are involved in the pathophysiology of hypertension. We hypothesize that treating hypertension with colchicine on top of standard therapy, will decrease pulse wave velocity (PWV), left ventricular mass, cardiac/inflammatory biomarkers. COHERENT was an investigator-initiated, single-center, prospective, randomized,…
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Modifying implementation strategies for integration of screening and management of mental disorders, including substance use disorders into other NCD care in Faridabad, Haryana as part of ICMR-MINDS project
CONCLUSION: The study highlights the importance of systematic approach and documentation for adapting implementation strategies to real-world conditions. The modified strategies intend to offer a feasible approach to integrated MSUD care in Faridabad district of Haryana. The findings indicate feasibility and system fit. Further evaluation is required to assess effectiveness and scalability.
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A Staff-Directed Electronic Medical Record Alert to Increase Chlamydia Screening: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of chlamydia screening, an alert directed to medical assistants was associated with increased odds of a test ordered in primary care practices. This study’s results suggest that an alert could increase the proportion of women screened for chlamydia and reduce the reproductive sequelae of this common STD.
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Efficacy and safety of intravenous prasinezumab in individuals with early-stage Parkinson’s disease on stable symptomatic monotherapy (PADOVA): a phase 2b, multicentre, randomised, double-blind, placebo-controlled study
BACKGROUND: Prasinezumab has previously shown potential for reducing the progression of motor signs (Movement Disorder Society-sponsored Revision of the Unified Parkinson’s Disease Rating Scale [MDS-UPDRS] Part III) in patients with early-stage Parkinson’s disease who were treatment-naive or receiving monoamine oxidase type B (MAO-B) inhibitors. The aim of the PADOVA trial was to evaluate the efficacy…
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Multicentre randomised controlled trial of the Norwegian health in work service for patients with common mental disorders or musculoskeletal disorders: the Norwegian Sickness Absence Clinic (NSAC) Efficacy Study
INTRODUCTION: In many countries, a high or increasing rate of sickness absence is challenging the sustainability of present sickness absence benefit schemes. Most sickness absence is certified on the grounds of common mental disorders or musculoskeletal disorders, and substantial effort has been invested in developing interventions promoting return to work for these patients. In Norway,…
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Induction of Cure in Early Arthritis (I CEA): results of a randomised clinical trial to compare three treatment strategies in recent onset undifferentiated arthritis
CONCLUSIONS: In patients with UA, early DMARD treatment led to greater improvement in disease activity over 3 months compared with NSAIDs, with the improvement for baricitinib reaching statistical significance. Over 12 months, disease activity was not significantly different across treatment arms, with overall favourable outcomes.
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Effects of pneumatic tube systems on next-generation viscoelastic coagulation test devices in septic patients and healthy individuals: Results of the randomized controlled VETaPT trial
Rapid coagulation assessment is essential in critical care to enable timely correction of coagulopathy. Viscoelastic testing (VET) supports this goal but may be affected by mechanical stress during transport by pneumatic tube systems (PTS). As PTS are widely used to expedite sample delivery, evaluating the robustness of next-generation VET and platelet function assays under these…
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![Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer’s disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study](https://i.aidevmd.com/wp-content/uploads/2025/03/itinai.com_A_close-up_shot_of_a_scientist_wearing_a_pristine__db6a7c73-f520-44e3-bb74-10eabe38d600_0.png)
Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer’s disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study
BACKGROUND: Tau PET imaging has emerged as a critical biomarker for Alzheimer’s disease, informing diagnosis, staging, and therapeutic selection. We investigated whether PET tracer selection alters tau detection.
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Intravitreal dexamethasone sodium phosphate challenge to predict implant response in refractory diabetic macular edema: a pilot study
CONCLUSION: A short-term dexamethasone sodium phosphate challenge is a safe, low-cost, and highly specific predictor of dexamethasone implant efficacy. This «test-and-treat» strategy may optimize resource allocation in resource-constrained settings by identifying responders before high-cost implantation.
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Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients — results of a prospective phase II trial (INTRAMET)
CONCLUSION: IORT to the resection cavity was associated with favorable local control and an acceptable safety profile. It may represent a feasible alternative to postoperative stereotactic radiosurgery in selected patients.