Clinical Trials
Category Added in a WPeMatico Campaign
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Cadonilimab combined with lenvatinib and transarterial chemoembolization for non-metastatic unresectable hepatocellular carcinoma: a multicenter, open-label, phase 2 study
CONCLUSIONS: Cadonilimab plus lenvatinib and TACE showed encouraging antitumor activity in patients with non-metastatic unresectable HCC. The safety profile was tolerable and manageable. The encouraging results observed warrant further study in larger clinical trials for this treatment combination.
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Empirical tuberculosis treatment in infants living with HIV hospitalised with severe pneumonia in Africa (EMPIRICAL): a multicentre, randomised, open-label, 2 2 factorial, controlled superiority trial
BACKGROUND: Mortality among infants with severe HIV-associated pneumonia remains high globally. The EMPIRICAL trial evaluated whether empirical tuberculosis treatment (eTB-T) improves survival compared with the currently recommended microbiologically and clinically guided strategy.
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Conditioned pain modulation is associated with anesthesia efficacy in patients with temporomandibular disorder
Conditioned pain modulation (CPM) assesses descending pain inhibition in humans and has been shown to be clinically relevant. However, the possible contribution of the CPM response to the efficacy of local anesthetics remains poorly understood. This study aimed to evaluate the association between the CPM response and the efficacy of topical anesthesia applied to the…
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Brief Report: Prognostic Value of Kaposi Sarcoma Herpes Virus-Associated Clinical Symptom Scores in HIV-Associated Kaposi Sarcoma
CONCLUSIONS: KSCS score symptoms are common, especially in advanced HIV-KS. KSCS score 3 is associated with higher risk of progressive KS disease or death, despite treatment with antiretrovirals and chemotherapy. This population may benefit from improved diagnostic and management options.
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Invasive versus conservative strategy for older patients with myocardial infarction based on cognitive function: the SENIOR-RITA cognition analysis
CONCLUSIONS: Among those with evidence of cognitive impairment at randomisation, an invasive treatment strategy did not reduce the primary composite outcome of cardiovascular death or nonfatal MI, and there was no evidence of treatment effect heterogeneity based on cognition. The reduction in nonfatal MI events among those with cognitive impairment should be interpreted as an…
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Effect of a lacto-vegetarian diet combined with 14-hour time-restricted eating on metabolic outcomes in women with Type 2 diabetes: a 24-week randomized controlled trial
CONCLUSION: A culturally adaptable lacto-vegetarian diet combined with a 14-hour time-restricted fasting regimen safely improves metabolic control and insulin sensitivity in women with Type 2 Diabetes, offering a practical, women-centric strategy that may be implementable within structured clinical nutrition services, although its staffing requirements, cost, and scalability require further evaluation.
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Computerised cognitive training combined with nutritional counseling in mild cognitive impairment — results of a 2 2 factorial randomized controlled trial (BrainFit-nutrition study)
CONCLUSION: The results of this study suggest, that in people with MCI, notable improvement in global cognition can be achieved in a six-months intervention period. When CCT is combined with digital nutritional counseling, the form of intervention — whether elaborate or basic — apparently did not modify the outcome; rather, this data set suggests that…
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Development and Initial Clinical Evaluation of a Stress-Induced Computerized Bowel Sound Analysis System for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is diagnosed using symptom-based criteria because no established physiological test objectively supports the diagnosis. We developed and evaluated a computerized bowel sound analysis system incorporating a dichotic listening task as a psychological stress challenge in three phases. In Phase 1, a short-time energy (STE)-based bowel sound extraction algorithm showed high sensitivity…
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Acupuncture after surgery of soft tissue tumors of the extremities: postoperative pain and feasibility: a prospective trial
CONCLUSION: Acupuncture was feasible, safe, and well accepted in this postoperative setting. Pain levels and opioid requirements remained low throughout the postoperative period. Further controlled studies are warranted to assess efficacy and to refine patient selection and acupuncture techniques in this setting.
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Assessing the psychometric properties of the Symptom Checklist Five-Items (SCL-5) instrument in a clinical setting for treating intimate partner violence
CONCLUSIONS: The results provide evidence that the SCL-5 has adequate psychometric properties in a Norwegian sample of perpetrators and victims of IPV.