Clinical Trials
Category Added in a WPeMatico Campaign
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Stereotype Threat and a Multiple Identity Intervention Among First- and Second-Generation Students of Migrant Descent
This study investigates the effects of stereotype threat on academic performance among first- and second-generation students of migrant descent in Austria and evaluates the effectiveness of a multiple identity intervention in mitigating such effects. In a randomized classroom quasi-experiment (N = 452, Mage = 15.15, 67.7% female), students were exposed to stereotype activation or control…
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Seven-Day vs Four-Day Infusion Set Replacement Interval and Catheter-Related Infections
CONCLUSIONS AND RELEVANCE: In this economic evaluation of the RSVP trial, a small increase in CRBSI risk was associated with large cost-savings and substantial health losses at the population level. While the RSVP trial assumed that a 2% equivalence margin was acceptable, the use of such arbitrary difference margins might not consider information that could…
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Clinical Evaluation of Thiamidol-Containing Formulations for the Visual Management of Facial Hyperpigmentation
CONCLUSION: These data support the use of Thiamidol-containing formulations as part of the overall management strategy for individuals affected by facial hyperpigmentation.  .
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Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne: A Pooled Analysis by Age
CONCLUSIONS: Fixed-dose, triple-combination CAB gel was efficacious and well tolerated in participants with moderate-to-severe acne, regardless of age. Approximately half of the participants achieved clear/almost clear skin, with >70% reductions in lesion counts.
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Efficacy and safety of topical GT20029 in male patients with androgenetic alopecia: a multicenter, randomized, double-blind, placebo-controlled phase 2 study
CONCLUSION: Topical GT20029 demonstrated significant efficacy in hair regrowth with good tolerability. Further studies are warranted to confirm its therapeutic potential in AGA.
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Modulating the lung-gut axis: A randomized controlled trial of Xie Bai Zeng Ye decoction on intestinal flora and mucosal immunity in children with post-infectious cough
CONCLUSION: This exploratory study suggests that XBZY may be a promising treatment option for children with post-infectious cough characterized by lung heat and Yin deficiency. Compared with Montelukast Sodium, XBZY demonstrated superior short-term improvements in cough resolution, symptom relief, quality of life, intestinal barrier function, and gut microbiota modulation, while maintaining good safety. These findings…
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Abdominal massage as an adjunctive therapy for pediatric functional constipation: a randomized controlled trial
CONCLUSION: A 12-session abdominal massage therapy program appears to be an effective adjunct treatment to standard pharmacological therapy for alleviating constipation-related symptoms in children. Larger, multicenter trials are needed to confirm these findings.
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Comparative evaluation of safety and efficacy of dapoxetine, silodosin, and citalopram in the management of premature ejaculation: a randomized clinical trial
CONCLUSION: In this direct head-to-head comparison of active treatments for lifelong PE, daily citalopram (20 mg) demonstrated superior efficacy in prolonging IELT and improving psychosocial outcomes compared to daily or on-demand dapoxetine and silodosin. The findings suggest that citalopram is a highly effective first-line option, while the dose-dependent efficacy of dapoxetine and the distinct side-effect…
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Hospital-Level Care at Home for Adults Living in Rural Settings: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of home hospital care in rural settings, cost and readmission were unchanged while patient activity and experience improved. Late transfer home likely attenuated the intervention’s effect.
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Magnetic seed versus guidewire-based breast cancer localization with magnetic lymph node detection: cost-minimization analysis
CONCLUSION: In this predefined health economic analysis of an RCT, the use of magnetic seeds resulted in incremental cost containment, despite the increased cost of the device. Contributing factors included shorter localization time, shorter operating time, and process streamlining.