Clinical Trials
Category Added in a WPeMatico Campaign
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Preliminary examination of the validity of a behavioral mindfulness measure in adults with advanced cancer and their family caregivers
OBJECTIVES: The breath counting task (BCT) has shown evidence of validity as a behavioral measure of mindfulness in healthy populations but remains largely untested in clinical contexts. The BCT is a computerized measure of present-moment awareness based on breath-counting accuracy. This study provides a preliminary evaluation of its validity in adults with advanced cancer and…
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Sit-To-Stand Breaks to Optimize Cardiometabolic Health Effects Following Exercise in Sedentary Adults With Dyslipidaemia: A Randomized Crossover Trial
Current physical activity (PA) guidelines recommend reducing prolonged sitting in addition to increasing PA. In this regard, the complementary effects of standing breaks to interrupt sitting, in addition to exercise, have not yet been evaluated. This study tested whether exercise alone or exercise combined with standing breaks enhances cardiometabolic outcomes compared with prolonged sitting in…
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The use of teleorthodontics and artificial intelligence for orthodontic triage and screening in a publicly funded healthcare system: A crossover randomized controlled trial
CONCLUSIONS: Teleorthodontics combined with DM™ is a valid and reliable tool for orthodontic screening of patients with mild and severe malocclusions but cannot be used to confidently assign IOTN-DHC grade for patients with borderline malocclusion severity yet. The duration of screening is significantly shorter using TAI.
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Belimumab outperforms placebo for attainment of modified DORIS remission and LLDAS without the glucocorticoid component: a post hoc analysis of five phase III SLE trials
CONCLUSION: Belimumab was associated with higher attainment of DORIS remission and LLDAS excluding the GC component versus placebo; attainment rates were approximately twofold higher than those previously reported using the full definitions.
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Treat-to-target strategies are feasible in elderly-onset rheumatoid arthritis given its reassuring risk-benefit profile
CONCLUSION: A T2T approach is feasible and effective in EORA, given its reassuring risk-benefit profile, while recognising the need for individualised management.
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Interesterified fats rich in palmitic and stearic acids have comparable effects on selected inflammatory related biomarkers
CONCLUSIONS: The finding suggests that the long-term effects of these three fats on these selected inflammatory related biomarkers are similar. Trial registration https://clinicaltrials.gov/ , NCT02192047, 2014-07-15.
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Effect of community-based intensive smoking cessation intervention on smoking behavior and blood pressure control in hypertensive patients
CONCLUSION: The intensive smoking cessation intervention significantly increased smoking abstinence rates, reduced cigarette consumption, and improved blood pressure control among hypertensive patients in community settings.
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Toward evidence-based prescription of prosthetic ankle-foot devices: A multisite randomized crossover trial identifying performance-based, patient-reported, and biomechanical parameters sensitive to device type
Prescription of prosthetic ankle-foot devices is constrained by imprecise clinical guidelines and inconsistent scientific evidence, hindering optimal device selection for individuals with lower limb loss. This multisite, prospective, randomized crossover study aimed to identify patient-reported, performance-based, and biomechanical parameters sensitive to ankle-foot device type, providing a foundation for more objective and individualized prescription practices. Ninety-one…
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Digital Simulation-Based Ultrasound Training for Physiotherapy Students: Prospective Randomized Controlled Trial
CONCLUSIONS: Simulation-based online ultrasound training provides comparable theoretical and practical outcomes to traditional on-site instruction, supporting its use as a scalable and accessible educational alternative.
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Testing behavioral economics principles in mailed FIT outreach: a randomized trial
CONCLUSION: The FIT test screening rate in the enhanced communication group was not statistically different from the original communication group. Using evidence-based behavioral economics principles in mailed FIT communications did not markedly improve the rate of CRC screening, but mailed FIT remains a key, cost-effective tool for reaching unscreened individuals.