Clinical Trials
Category Added in a WPeMatico Campaign
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Catheter Ablation for Frequent Premature Ventricular Contractions or Paroxysmal Supraventricular Tachycardia With Vagal Bradycardia: A New Clinical Application of Superior Vena Cava-Aorta Ganglionated Plexus Modification
CONCLUSION: The simplified right atrial Ao-SVC GP ablation effectively treats vagal bradycardia. Additionally, combining it with radiofrequency ablation for concurrent tachyarrhythmia offers a safe and innovative therapy.
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The Impact of Different Oral Antidiabetic Drugs on Insulin Pump Intensive Therapy in Type 2 Diabetes Patients: A Clinical Study
CONCLUSION: These findings suggest that compared with metformin, dapagliflozin combined with intensive insulin pump therapy holds greater promise for optimizing glycaemic control in patients with T2DM, thus providing a more promising option for clinical practice.
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Effect of Intraoperative Low-Dose Esketamine on Postoperative High-Sensitivity Troponin T in Elderly Patients Undergoing Ivor Lewis Esophagectomy
CONCLUSION: Intraoperative low-dose esketamine effectively reduced hs-cTnT concentrations within 2 days postoperatively in elderly patients undergoing Ivor Lewis esophagectomy, demonstrating a potential beneficial effect in preventing myocardial injury and cardiovascular adverse events.
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The Investigation of the Effects of Group Exercise Treatment on Psychological Status, Muscle Strength, Respiratory Performance, and Balance Parameters in Hospitalized Patients in Psychiatry Departments: A Randomized Clinical Study
CONCLUSION: Group-based breathing, posture, and stretching exercises had greater effects on psychological symptoms than on physical performance parameters in psychiatric inpatients. These findings suggest that structured exercise interventions may serve as a valuable adjunct to medical treatment in this population.
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Influence of Device and Format: A Randomized Controlled Trial of an Electronic Health Record-Integrated Symptom Screening Questionnaire for Pediatric Patients With Cancer
CONCLUSION: Completing SSPedi on a computer or phone, each of which presented SSPedi differently, did not affect ease of use or bias results. Although the phone was more commonly preferred, availability of SSPedi via both phone and computer will be important for implementation of routine symptom screening in pediatric patients with cancer to provide patients…
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Virtual Reality Versus In-Person Simulation of Sepsis for Medical Students: Randomized Comparative Pilot Study
CONCLUSIONS: This study demonstrates the feasibility of the proposed trial method and provides insight into likely effect sizes for the design of further studies. The measured learning outcomes were similar across the groups, regardless of which simulation modalities were used prior to assessment. Our study found no statistically significant differences for VR simulation versus IP…
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Digital Intervention (MiVacunaLA 2.0) to Promote COVID-19 Vaccine Acceptance Among Hispanic Children: Community-Based Randomized Controlled Trial
CONCLUSIONS: MiVacunaLA demonstrates that a culturally tailored, community-based, mobile phone-delivered vaccine educational intervention can increase COVID-19 vaccine uptake among Hispanic children and improve caregivers’ trust in governmental vaccine processes. MiVacunaLA is innovative in its integration of community-informed design with a fully automated, mobile phone-centric format and builds on prior literature by prospectively evaluating a culturally…
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Efficacy and safety of efgartigimod in the treatment of impending myasthenic crisis
CONCLUSION: Efgartigimod demonstrated comparable efficacy to IVIg for IMC remission but with a significantly faster onset, supporting its role as a rapid and safe alternative.
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The effect of perioperative lidocaine during modified radical mastectomy on postoperative pain and immune response: A randomized clinical trial
CONCLUSION: Perioperative systemic lidocaine infusion in patients with breast cancer could modulate the production of IL-6, and through the reduction of this cytokine, patients experienced better pain control in the immediate postoperative period.
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Efficacy and Safety of Escitalopram in Alleviating Depression and Anxiety Symptoms in COPD Patients: A Randomized Double-Blind Placebo-Controlled Trial
CONCLUSION: Short-term treatment with low-dose escitalopram significantly alleviates depression and anxiety in COPD patients. Notably, this brief intervention initiated a sustained positive clinical trajectory over 12 months. Combined with a favorable safety profile, these findings support its potential integration into comprehensive COPD management protocols, pending multicenter validation.