Clinical Trials
Category Added in a WPeMatico Campaign
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Interdisciplinary collaborative teaching in vascular surgery training: A randomized trial of radiologist-surgeon partnership in China
This randomized controlled trial evaluates an innovative interdisciplinary teaching model co-led by radiologists and vascular surgeons within China’s standardized residency training program. Forty trainees were randomized into two groups: one receiving collaborative teaching, which included joint lectures, radiologist-attended ward rounds, and interdisciplinary case conferences; and the other undergoing traditional vascular single-discipline training. The experimental group…
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Phosphatidylethanol as an objective measure of heavy drinking days in a clinical trial for alcohol use disorder
CONCLUSIONS: Our findings support the use of PEth as an objective measure of heavy drinking days in a clinical setting. Further research is needed to validate these findings in larger cohorts.
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Effect of irrigation solution temperature during pars plana vitrectomy on early postoperative choroidal vascularity
CONCLUSION: PPV caused an early postoperative decrease in choroidal perfusion, which was significant in the cold irrigation group. However, there was no significant difference between cooled and room-temperature irrigation solutions.
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Audiological profile for assessment of sensorineural hearing loss in treatment naïve chronic myeloid leukemia: impact of early TKI treatment on reversibility
Sensorineural hearing loss (SNHL) is an underrecognized manifestation in chronic myeloid leukemia (CML), particularly in the setting of hyperleukocytosis. Its prevalence, pathophysiology, and response to tyrosine kinase inhibitor (TKI) therapy remain poorly characterized. To assess the prevalence, severity, and reversibility of SNHL in treatment-naïve CML patients and evaluate associations with leukocyte count and disease risk.…
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Impact of Patient-Controlled Bag Squeeze on Pain and Anxiety in Male Patients Undergoing Flexible Cystoscopy: A Double-Blind Randomized Control Study
CONCLUSIONS: Patient-controlled bag squeeze appears to be a safe and effective analgesia method comparable to caregiver-assisted methods, and demonstrates favorable patient preference.
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Comparison of cognitive workload between very short answer questions and multiple-choice questions: an eye-tracking experiment
Very short answer questions (VSAQs) have gained attention for their superior psychometric properties compared to multiple-choice questions (MCQs). While VSAQs require knowledge recall, MCQs primarily involve knowledge recognition. This difference in cognitive processes may lead to varying cognitive workloads, defined as the amount of mental processing in working memory. Previous studies have not demonstrated consistent…
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Oral diclofenac potassium and intramuscular hyoscine-n-butyl bromide versus oral diclofenac potassium alone for pain relief during hysterosalpingography: a double blind randomized controlled trial
Hysterosalpingography (HSG) is an important diagnostic tool in infertility, often associated with pain and tubal spasms, potentially resulting in false proximal tubal occlusions. This randomised controlled trial compared oral diclofenac potassium plus intramuscular hyoscine-N-butyl bromide (HBB) with oral diclofenac alone in 138 women undergoing HSG at Central Hospital, Warri. Pain perception, the primary outcome, was…
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RTMS Versus Fluvoxamine in the Treatment of OCD: A Randomized Open-label Pilot Study
Background: Obsessive‒compulsive disorder is a chronic, disabling mental disorder. While repetitive transcranial magnetic stimulation has emerged as a promising neuromodulation intervention for psychiatric disorders, its efficacy in treatment-naïve obsessive‒compulsive disorder patients remains understudied. Objective: This study aimed to test the preliminary efficacy of low-frequency repetitive transcranial magnetic stimulation in treatment-naïve obsessive‒compulsive disorder patients. Methods:…
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Efficacy and safety of SMET12 in combination with toripalimab and chemotherapy in advanced non-small-cell lung cancer patients tested positive for EGFR protein who are treatment-naive or harbor acquired resistance to standard therapy: a phase 2, multi-cohort clinical trial
CONCLUSIONS: Triple therapy consisting of SMET12, toripalimab, and chemotherapy exhibited manageable safety in patients with advanced non-small cell lung cancer (NSCLC) expressing EGFR protein, while demonstrating promising efficacy in EGFR-mutant patients with acquired resistance to EGFR-TKIs. The functional phenotype and differentiation pattern of peripheral blood T lymphocytes exert a critical impact on the therapeutic response…
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Randomized, Double-Blind, Placebo-Controlled Trial of ID-CBT5101, a Tyndallized Clostridium butyricum Postbiotic, in Adults with Mild-to-Moderate Knee Osteoarthritis
Osteoarthritis (OA) is a common cause of chronic pain and functional impairment in older adults. Evidence suggests a gut-joint axis, where gut dysbiosis and systemic low-grade inflammation may contribute to OA pathogenesis. Postbiotics, which are non-viable microbial products such as heat-killed bacteria, have been proposed as safe and stable alternatives to live probiotics. ID-CBT5101, a…