Clinical Trials
Category Added in a WPeMatico Campaign
-
The effect of psychosocial skill-oriented group psychoeducation on functional recovery, treatment adherence, and mental well-being in patients diagnosed with schizophrenia: A randomized controlled trial
CONCLUSIONS: The findings indicate that psychosocial skills-focused group psychoeducation was associated with improvements in self-reported treatment compliance (although the low reliability of the adherence measure in this sample warrants cautious interpretation) in individuals diagnosed with schizophrenia and is an effective intervention for improving mental well-being and functional capacity. To increase the effectiveness of psychosocial skills-focused…
-
The effect of psychodrama-based group work on postpartum women’s depression and forgiveness tendencies: A randomised controlled study
CONCLUSION: Psychodrama-based group work increased forgiveness tendencies and reduced depression levels among postpartum women. In this regard, it is recommended that psychodrama sessions be conducted with postpartum women.
-
Reducing the diagnostic and treatment gap for priority mental, neurological and substance misuse disorders in primary care in rural Kenya: Results of a stepped wedge cluster randomized trial from the EPINA study
In resource-limited settings, improving care for mental, neurological and substance misuse (MNS) disorders is essential. This study evaluated the feasibility and effectiveness of implementing all adult modules of the WHO mental health Gap Action Programme Intervention Guide (mhGAP-IG) in primary healthcare (PHC) in rural Kenya through training non-specialist primary healthcare workers. We conducted a stepped-wedge…
-
Detection of Cataract and Surgical Outcomes in the Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)
CONCLUSION: Cataract detection in underserved individuals was associated with older age, poor visual acuity, and unreadable fundus images but cataract surgery rates were low.
-
Endobronchial Ultrasound-Guided Fine Needle Biopsy in the Diagnosis of Mediastinal Lymphadenopathy: A Randomized Trial
CONCLUSION: Despite similar diagnostic yields, FNB was more effective than FNA in providing larger, adequate core tissue samples. This improvement in specimen quality may suggest a potential clinical benefit for comprehensive diagnosis and advanced pathologic work-up.
-
Educational intervention to improve adherence after acute coronary syndrome
CONCLUSION: The educational intervention was well accepted and feasible to implement, but it did not result in improved medication adherence or a reduction in clinical events over the medium term.
-
VOLUMETRIC AND RADIOGRAPHIC OUTCOMES OF BONE REGENERATION AFTER APICOECTOMY WITH PRF-BASED THERAPIES — A PRELIMINARY STUDY
CONCLUSION: PRF enhances bone regeneration after apicoectomy, especially when combined with Bio-Oss, without increasing postoperative morbidity. CBCT volumetric assessment provides superior evaluation of regenerative outcomes.
-
STANDARDIZED PATIENT-BASED TRAINING AND CLINICAL DIAGNOSTIC COMPETENCE AMONG MEDICAL STUDENTS: A RANDOMIZED COMPARATIVE STUDY
CONCLUSIONS: Standardized patient-based training was associated with improved clinical diagnostic performance, particularly among students with average or lower academic standing. These findings support the integration of standardized patients into hybrid clinical curricula to strengthen diagnostic competence and communication skills.
-
Prospective collection of bleeding rate and factor usage in participants with hemophilia A and B in a noninvestigational product study
CONCLUSION: This study provides a robust, prospective, informative dataset on bleeding rates in participants receiving factor replacement therapy over a mean follow-up of ∼1 year. Although FVIII/FIX prophylaxis was generally well tolerated, bleeding rate data illustrate the limitations of current standard-of-care factor prophylaxis.
-
Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial
This study investigated the effects of ashwagandha root extract (ARE) supplementation on core attention-deficit/hyperactivity disorder (ADHD) symptoms, executive functioning, and patient-reported outcomes in children and adolescents with mild ADHD. Fifty-eight children and adolescents with clinically diagnosed mild ADHD were randomly assigned to either the ARE group (ARE; n = 29) or a placebo group (PLA;…