Clinical Trials
Category Added in a WPeMatico Campaign
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Hospital-Based Psychosocial Case Management and Suicide Prevention in South Korea: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this RCT of outpatients with MDD and high suicide risk, ACM significantly reduced C-SSRS total scores and psychological distress compared with usual care. These findings provide a critical, high-level evidence base for the national implementation of standardized, hospital-centered psychosocial interventions as a scalable public health strategy for suicide prevention.
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Short-term OCT-based evaluation of corneal epithelial remodeling with two silicone hydrogel bandage contact lenses after t-PRK
CONCLUSIONS: Both bandage contact lens materials demonstrated broadly comparable short-term postoperative epithelial remodeling patterns and refractive outcomes after t-PRK. Minor early regional differences observed on OCT should be interpreted cautiously.
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Cost-effectiveness of immediate septoplasty versus medical management with the option for delayed septoplasty for nasal airways obstruction: a multicentre, open-label, randomised controlled trial
CONCLUSIONS: Over a 24-month time horizon, immediate septoplasty would be cost-effective in the management of deviated nasal septum.
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At-Home Transvaginal Pelvic Ultrasonography and Image Quality in Premenopausal Women: A Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This nonrandomized clinical trial of at-home pelvic ultrasonography in premenopausal women demonstrated that broad use of at-home gynecologic ultrasonography technology is feasible, safe, and preferred by participants and sonographers compared with in-clinic ultrasonography. At-home ultrasonographic imaging presented an innovative and clinically acceptable alternative to in-clinic care, providing opportunities for improved access to…
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Evaluating the Safety and Efficacy of Sirolimus Topical Gel 0.2% to Treat Acanthosis Nigricans
CONCLUSION: Sirolimus gel 0.2% was safe and effective for AN, producing early improvements in pigmentation, texture, and patient-reported outcomes. Larger randomized controlled trials are warranted to validate these findings.  .
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Efficacy and Tolerability of a Topical Pigment-Correcting Serum in Melasma and Postinflammatory Hyperpigmentation
CONCLUSIONS: The LTN serum is an effective treatment for improving melasma and PIH, particularly among participants with FST IV–VI.  .
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Stapokibart provides significant improvements in signs and symptoms of atopic dermatitis irrespective of prior systemic treatment: a post-hoc analysis of a phase 3 trial
CONCLUSIONS: Stapokibart demonstrated significant clinical efficacy and manageable safety in AD patients irrespective of prior systemic treatment.
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Clinical efficacy and electromyographic analysis of direct current hydrotherapy in the treatment of upper limb peripheral nerve injuries: A randomized controlled trial
PurposeThis study aimed to investigate the reparative effect and therapeutic efficacy of direct current hydrotherapy in the treatment of upper extremity peripheral nerve injury to provide a reference for the clinical treatment of peripheral nerve injury in the future.MethodBetween September 2022 and June 2023, 66 eligible patients with upper extremity peripheral nerve injury were enrolled…
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GABAergic Modulation of Brain Function During Prosaccade and Antisaccade Eye Movements: Evidence From Ultra-High-Field fMRI
Benzodiazepines act as positive allosteric modulators of the GABA(A) receptor and affect several motor and cognitive functions. By engaging perceptual-motor as well as inhibitory control processes, the antisaccade task was used in previous studies to investigate effects of benzodiazepines on behavioral performance. Using a randomized, double-blind, placebo-controlled within-subjects design, this study combined eye-tracking with BOLD…
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A Comparative Study Assessing the Effect of Balance Training with and without Taping on Mobility in Stroke Patients
CONCLUSION: Balance training with taping is more effective for the improvement of mobility than balance training without taping in sub- acute to chronic stroke patients.