Clinical Trials
Category Added in a WPeMatico Campaign
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The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo-controlled, crossover study
CONCLUSIONS: Inhalation of 40 mg dry NaCl was well tolerated without acute adverse effects in COPD patients. However, early termination left the study underpowered, increasing the risk of type II error. Non-significant findings should not be interpreted as evidence of no effect. Larger, adequately powered trials are needed to clarify the impact of dry NaCl…
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Psychologically informed reminder messages for promoting BRCA1/2 carrier screening: evidence from a large-scale population-based study
Psychologically Informed Reminder Messages (PIRMs) may promote health-behavior change, but their impact on preventive genetic screening is unclear. Due to low adherence to a screening program, Clalit Health Services initiated an intervention to encourage BRCA1/2 carrier screening in July 2022. This observational study assesses the effectiveness of the intervention in encouraging screening and its spillover…
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Correlates and Predictors of Criminal Legal Involvement in People With First-Episode Psychosis
Objective: Because limited research has evaluated criminal legal involvement (CLI) during a first episode of psychosis (FEP), we explored rates, correlates, and predictors of CLI among people with FEP.
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Comparative effects of caffeine and paraxanthine on rowing performance and sleep quality: a randomized crossover study
CONCLUSION: These results indicate that the combined ingestion of caffeine and paraxanthine elicited the most pronounced performance benefits, while paraxanthine alone did not demonstrate clear standalone ergogenic efficacy at the administered dose. However, paraxanthine was associated with better subjective sleep outcomes compared to caffeine, suggesting that its potential value may be related more to tolerability…
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Efficacy and cost analysis of two fluoride varnishes in community-based interventions for early childhood caries
CONCLUSIONS: I-ReHealth^(®) is non-inferior to Duraphat® in caries-preventive efficacy but superior in cost-effectiveness in reducing patient expenses.
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Effectiveness of virtual reality technology combined with conventional pelvic floor rehabilitation training in postpartum myofascial pelvic pain syndrome: A randomized controlled trial
CONCLUSION: The integration of virtual reality technology with conventional pelvic floor rehabilitation therapy has the potential to improve the relaxation capacity of fast-twitch muscle fibers within the pelvic floor muscles. However, it does not seem to offer any benefits in increasing pelvic floor muscle thickness or in alleviating myofascial pelvic pain.
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Amikacin liposome inhalation suspension in newly diagnosed Mycobacterium avium complex lung disease (ARISE): a 6-month double-blind, active comparator trial
CONCLUSIONS: More patients with newly diagnosed MACLD receiving 6 months of ALIS alongside a macrolide-based regimen achieved culture conversion by month 6 and month 7 numerically more rapidly versus comparator. No new safety signals were identified.Clinical trial registered with www.clinicaltrials.gov (NCT04677543).
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Two-Year Outcomes of Less Invasive Surfactant Administration Among Preterm Neonates: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this secondary analysis of a randomized clinical trial of preterm infants supported with CPAP, early caffeine administration plus LISA did not reduce the incidence of death or moderate to severe NDI noted on the BSID. Infants who received LISA were more likely to have a fine motor domain score in the…
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Significant Incidental Findings in the National Lung Screening Trial and Diagnosis of Extrapulmonary Cancer
CONCLUSIONS AND RELEVANCE: This cohort study found that cancer SIFs were associated with an increased risk of an extrapulmonary cancer diagnosis in the year following an LDCT lung cancer screening examination. These findings suggest that certain SIFs should be evaluated as potential indicators of undiagnosed cancers.
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Comparison of Post-Cementation Sensitivity Between Resin Modified Glass Ionomer Cement and Conventional Glass Ionomer Cement as a Luting Material-A Randomized Clinical Trial
CONCLUSION: RMGIC demonstrated significantly lower post-cementation sensitivity compared to conventional GIC.