Clinical Trials
Category Added in a WPeMatico Campaign
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Comparison of oral tizanidine and baclofen for post-operative pain management after femoral fracture surgery
CONCLUSIONS: Preoperative administration of 4 mg tizanidine and 25 mg baclofen showed comparable efficacy in post-operative pain management. As this study lacked a placebo control, it cannot confirm the absolute analgesic efficacy of either drug over no treatment. Although tizanidine demonstrated a trend toward lower pain scores at certain intervals, these differences were not statistically…
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A randomised, double-blind, placebo-controlled crossover trial on cannabinoid-based medication for behavioural disorders in old patients with severe dementia: the study results
CONCLUSIONS: In this real-life crossover study, THC/CBD oil did not show superiority over placebo in reducing agitation in severe dementia. However, it was safe and associated with a significant reduction in the use of as-needed psychotropic medications prescribed for behavioural and psychological symptoms of dementia. CBM may represent a possible adjunctive option in selected patients,…
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Beware of What You Expect? A Partial Replication Study on the Behavioral and Psychophysiological Effects of Negative Expectations on Mechanical Hypersensitivity
Mechanical hypersensitivity of uninjured skin surrounding a cutaneous injury is a sign of plasticity of the nociceptive system and can be induced in healthy individuals using high-frequency electrical stimulation (HFS). However, despite a broad body of evidence for acute painful stimuli, mixed results have been reported concerning the role of negative expectations in the development…
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Effectiveness of Lotrafilcon B and Balafilcon A bandage contact lenses on epithelial healing and visual symptoms after transepithelial photorefractive keratectomy in the hyperopic patients
CONCLUSIONS: Lotrafilcon B bandage contact lenses are more effective than Balafilcon A lenses in reducing ocular pain during the postoperative period of T-PRK.
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Prospective Comparison of Ultra-Low-Dose Versus Standard-Dose Computed Tomography for Esophageal Foreign Body Detection
The objective of this study was to verify the non-inferiority of ultra-low-dose computed tomography (ULD-CT) versus standard-dose CT (SD-CT) for esophageal foreign body (EFB) detection and to quantify dose-quality trade-offs. This prospective, randomized, blinded-reader study enrolled 180 patients (120 adults, 60 children) presenting with suspected EFB ingestion. Patients were randomized to ULD-CT (100 kV/50 mA,…
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Gross motor function, functional level, physical performance, and muscle strength in preschool children newly diagnosed with cancer: Data from the RePlay trial
CONCLUSION: These results show that preschoolers newly diagnosed with cancer have gross motor function, functional level, and muscle strength impairments, underlining the importance of targeted physical rehabilitation.
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Glycated Albumin Guided Therapy in Newly Diagnosed Type 2 Diabetes A Randomized Controlled Trial
CONCLUSION: GA-guided therapy did not enhance HbA1c < 7% achievement; however, its potential benefits for more stringent glycemic targets and metabolic parameters in early diabetes management deserve further investigation.
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A community-based protective behavioral strategies program for hazardous alcohol use among middle-aged men in rural Vietnam: A randomized controlled trial
CONCLUSION: The culturally adapted PBS-based group intervention reduced alcohol consumption and intention to drink among middle-aged rural Vietnamese men with HAU. Trials with attention-matched controls are needed.
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The effect of psychosocial skill-oriented group psychoeducation on functional recovery, treatment adherence, and mental well-being in patients diagnosed with schizophrenia: A randomized controlled trial
CONCLUSIONS: The findings indicate that psychosocial skills-focused group psychoeducation was associated with improvements in self-reported treatment compliance (although the low reliability of the adherence measure in this sample warrants cautious interpretation) in individuals diagnosed with schizophrenia and is an effective intervention for improving mental well-being and functional capacity. To increase the effectiveness of psychosocial skills-focused…
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The effect of psychodrama-based group work on postpartum women’s depression and forgiveness tendencies: A randomised controlled study
CONCLUSION: Psychodrama-based group work increased forgiveness tendencies and reduced depression levels among postpartum women. In this regard, it is recommended that psychodrama sessions be conducted with postpartum women.