Clinical Trials
Category Added in a WPeMatico Campaign
-
Effectiveness of cold application combined with progressive muscle relaxation in migraine without aura: A randomized controlled trial
CONCLUSION: Both JPMR and JPMR combined with cold application are effective short-term interventions for managing migraine without aura. However, the addition of cold application enhances outcomes in the number of attacks. This combined nonpharmacological approach may be considered as an adjunct strategy for migraine management.
-
Comparison of effect of massage or chicory bath on bilirubin levels in term newborns undergoing phototherapy: a randomized clinical trial
CONCLUSION: Based on the results of the present study, Field massage combined with phototherapy was more effective in increasing the frequency of defecation and reducing the length of hospitalization in infants with hyperbilirubinemia compared to those in the chicory bath group and the control group who received phototherapy only.
-
Daratumumab plus lenalidomide maintenance in newly diagnosed multiple myeloma after transplant: AURIGA subgroup analyses
In the primary analysis (32.3-month median follow-up) of the randomized, phase 3 AURIGA study (NCT03901963), daratumumab-lenalidomide (D-R) maintenance significantly improved MRD-negative conversion rates and reduced the risk of disease progression or death by 47% versus R maintenance in anti-CD38 monoclonal antibody-naïve and post-transplant MRD-positive patients with newly diagnosed MM. Here, we present a post hoc…
-
Non-invasive high frequency oscillatory ventilation for primary respiratory support in extremely preterm infants: multicentre randomised controlled trial
CONCLUSIONS: NHFOV appeared superior to NCPAP in reducing the need for intubation when used as a primary respiratory support strategy in extremely preterm infants. Both techniques did not show significant differences in neonatal adverse events.
-
Efficacy and safety of avacopan for treatment of patients with ANCA-associated vasculitis receiving cyclophosphamide
CONCLUSIONS: This subgroup analysis of patients who received CYC shows similar rates of remission in the avacopan and prednisone taper groups. Compared with the prednisone taper regimen, the avacopan regimen was associated with a numerically lower relapse rate, greater improvement in eGFR, faster reduction in UACR, lower glucocorticoid-related toxicity and similar overall safety. These results…
-
Metabolomic profiling of patients with lupus nephritis reveals unique metabolites that are modulated through type I interferon inhibition by anifrolumab treatment in a phase 2 trial
CONCLUSION: Our findings establish a connection between type I interferon signalling, pyrimidine metabolism and uremic toxins in patients with LN and support the evaluation of urine uracil as a potential biomarker of response to anifrolumab.
-
The impact of a multi-component hospital avoidance programme in residential aged care homes: a stepped-wedge cluster randomised trial
CONCLUSIONS: Whilst not statistically significant, findings indicate that the intervention was associated with fewer ED transfers, but increased hospital admissions and overall hospital bed days. Programme implementation was impacted by major contextual barriers, notably the COVID-19 pandemic, which contributed to pressures on staffing and workload.
-
Empowering outpatients with breast cancer: The impact of a Continuous Care Program on self-efficacy-a randomized clinical trial
CONCLUSION: The study found that the CCP is effective in enhancing the self-efficacy of women with breast cancer in Iran. This program can be a beneficial method for improving patients’ well-being and delivering appropriate care to this population. The program can be shared with nurses in oncology departments to help them tailor their care plans…
-
Pharmacotherapy versus photobiomodulation therapy in patients with temporomandibular disorders: randomized clinical trial
CONCLUSION: Photobiomodulation therapy was more efficient in the improvement of pain, mouth opening, joint clicking, and tenderness of TMDs compared to the pharmacotherapy with MEGAFEN. Further investigations are required to establish a standard laser protocol for TMDs.
-
Evaluation of Postoperative Pain with Cryotherapy after Single-visit Endodontics in Teeth with Symptomatic Irreversible Pulpitis and Apical Periodontitis
CONCLUSION: The findings suggest that cryotherapy with cold saline is significantly more effective than regular saline in reducing postoperative pain in patients with symptomatic irreversible pulpitis and apical periodontitis. This method effectively lowers pain levels at 24 and 48 hours, improving patient comfort and satisfaction.