Clinical Trials
Category Added in a WPeMatico Campaign
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The cost-effectiveness of the stopping elderly accidents, deaths and injuries options randomised quality improvement trial to prevent falls among older adults
CONCLUSION: Within the study cohort, the intervention was highly likely to be cost-effective. However, differences in medically treated falls and total healthcare costs were not statistically significant; therefore, we cannot rule out the possibility that the intervention had no impact.
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Group Therapy for Posttraumatic Stress Disorder Symptoms Among Veterans With Military Sexual Trauma: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This randomized clinical trial showed that both treatments demonstrated efficacy in reducing PTSD symptoms, but the MST-focused treatment compared with the active control demonstrated greater improvements in posttraumatic cognitions. The results support the use of the MST-focused group treatment for PTSD symptoms associated with MST.
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Baseline serum metabolites predict fractures in individuals who were Black and had type 2 diabetes
CONCLUSION: In summary, the metabolic differences identified here highlight the role of altered systemic metabolism and its relationship to fracture risk. Future investigations will determine if the identified metabolites serve as predictors of fracture in patients with T2D who are not Black.
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Phase Ib, multicentre, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of subcutaneously administered mosunetuzumab in participants with systemic lupus erythematosus
CONCLUSIONS: Mosunetuzumab demonstrated dose-dependent peripheral B-cell depletion and a safety profile consistent with prior studies in follicular lymphoma. Based on these data, mosunetuzumab is currently being evaluated in a phase II study in severe SLE (NCT07598396).
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Trauma-focused therapy integrated with cognitive behavioural therapy for psychosis for people with post-traumatic stress disorder and psychosis (the STAR trial): a multicentre, pragmatic, randomised trial in the UK
BACKGROUND: People with psychosis have high rates of post-traumatic stress disorder (PTSD), which is associated with a poor prognosis. We aimed to investigate the effectiveness of a trauma-focused therapy integrated with cognitive behavioural therapy for psychosis (CBTp) in people with psychosis.
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Safety and efficacy of levacetylleucine in ataxia-telangiectasia: a phase 3, randomised, double-blind, placebo-controlled crossover trial
BACKGROUND: Ataxia-telangiectasia is a rare, autosomal recessive neurodegenerative disorder. Levacetylleucine (N-acetyl-L-leucine) has been shown to be efficacious for the treatment of neurological manifestations and to have a disease-modifying effect in lysosomal storage disorders such as Niemann-Pick disease type C. We aimed to assess the safety and efficacy of levacetylleucine for paediatric and adult patients with…
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Phase II Study of Adavosertib in Patients With Tumors Containing BRCA1 and BRCA2 Mutations: Results From the NCI-MATCH ECOG-ACRIN Cancer Research Group (EAY131) Subprotocol Z1I
CONCLUSION: In heavily pretreated, advanced solid tumor patients with PV in BRCA1/2, adavosertib treatment resulted in low ORR, and this trial did not meet the primary end point.
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Early vs Late Initiation of Extracorporeal Membrane Oxygenation: Protocol for a Prospective, Randomized, Multicenter Study
CONCLUSIONS: The ELIEO trial will provide robust evidence regarding the optimal timing of vvECMO initiation in patients with severe ARDS. The findings may influence clinical decision-making, resource allocation, and organizational strategies for the management of ARDS in specialized intensive care settings.
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Identifying MicroRNA Biomarkers in Idiopathic Intracranial Hypertension: A Pilot Study
BACKGROUND AND OBJECTIVES: Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure (ICP). It predominantly affects women with obesity and can cause disabling headaches and permanent visual loss. IIH is misdiagnosed in up to 40% of cases. Diagnosis and monitoring often rely on frequent invasive lumbar puncture. This pilot study aimed to identify serum…
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Integrating Metronomic Therapy With Standard Chemotherapy in Advanced Unresectable Head and Neck Cancer: A Randomized Trial Addressing Global Cancer Care Equity (METRO PLUS)
CONCLUSION: In platinum-sensitive advanced HNSCC, the addition of triple OMCT to PC significantly improved OS and PFS with acceptable toxicity. PC + OMCT represents a feasible and cost-conscious first-line option in resource-constrained settings.