Clinical Trials
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Fluoxetine versus N-acetylcysteine in reducing craving in Indian men with alcohol dependence syndrome: a randomised controlled trial
CONCLUSION: Both fluoxetine and NAC were effective in reducing alcohol craving over 12 weeks, with greater reduction in the NAC group at each follow-up assessment. The NAC group also had a lower relapse rate and better adherence and tolerability.
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Effects of Asparagus-Derived 20-Hydroxyecdysone Supplementation on Fat Oxidation and Insulin Sensitivity in Resistance-Trained Males
This study investigated the effects of 20-hydroxyecdysone (20E) derived from Asparagus officinalis extract on substrate utilization and metabolic health in young males undergoing resistance training (RT). Twenty healthy males were randomly assigned in a double-blind design to receive either a placebo (PLA; n=10) or 30 mg/d of 20E (n=10) for 12 wk, during which all…
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A first-line regimen combining Bruton’s tyrosine kinase and programmed cell death protein-1 inhibitors with chemotherapy excluding methotrexate achieves high response rates in primary central nervous system lymphoma
CONCLUSIONS: Orelabrutinib combined with PD-1 blockade and fotemustine demonstrated high antitumor activity with manageable toxicity, supporting its potential as a frontline regimen for PCNSL.
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Clinical trial of press needle therapy with low-dose atropine for mild myopia in children
CONCLUSION: Periocular acupuncture with low dose atropine solution (.01%) seems to be a safe and more effective method as compared with conventional treatment alone for controlling mild myopia in children. Large scale trials should be conducted for validating these findings.
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Prognostic value of T-lymphocyte subsets, lymphocyte-to-high-density lipoprotein ratio, interleukin 6, C-reactive protein and procalcitonin in patients with septic shock and effects of vitamin C on patients with septic shock
CONCLUSION: The combination of LHR, IL-6, CRP, PCT and CD4+/CD8+ has prognostic value. Vitamin C adjunct therapy significantly enhances hemodynamic improvement, reduces inflammation, lowers SOFA scores and improves prognosis in septic shock patients.
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Effectiveness and safety of alprostadil injection in the treatment of patients with type 2 diabetes complications
CONCLUSION: Alprostadil injection as an adjunctive therapy for T2DM-related DF or DPN exhibits significant efficacy and good safety. It not only enhances the overall therapeutic response but also effectively improves lipid metabolism disorders, with a low incidence of adverse events.
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Ultra-Early Continuous ECG Monitoring for Silent Atrial Fibrillation Diagnosis in Cryptogenic Stroke: The CRIPTOFAST Randomized Controlled Trial
CONCLUSIONS: An ILR implanted early after CS improves the detection of PAF compared to standard care. Individuals with abnormal LA features may benefit the most from ILR.
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Impact of Xpert® Carba-R-based screening for carbapenem-resistant organisms on infection-related mortality in hematopoietic stem cell transplant recipients
CONCLUSIONS: Our study showed a positive effect of more rapid CRO colonization screening using rectal swabs with Xpert Carba-R and culture, which can guide potent CRO preemptive therapy for subsequent infections based on the detected carbapenemase mechanism, thereby reducing mortality and the spread of CRO infection in HSCT patients.
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Regional multi-center randomized trial of three vonoprazan-amoxicillin dosing regimens for Helicobacter pylori eradication in Sichuan Province, China
CONCLUSION: VPZ-AMO dual therapy achieved excellent eradication, safety, and patient compliance. All regimens were similarly effective, whereas the 0.5 g QID dosing strategy offered the most favorable balance of efficacy and tolerability, supporting its use as a first-line option in high-prevalence settings.
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Functional, Radiological, and Scapular Motion Evaluation of Surgical Versus Nonsurgical Treatment of Type 3 Acromioclavicular Dislocations: A Randomized Controlled Trial With 24 months’ Follow-up
CONCLUSION: Surgical management of type 3 AC joint dislocations resulted in similar DASH scores and range of motion compared with nonoperative management, although some secondary outcomes-including higher UCLA scores and cosmetic satisfaction scores-favored surgery.The trial was registered in the Brazilian Registry of Clinical Trials (RBR-4r6jhy6).