Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of a DBT-Informed Dyadic Intervention (Better Together) on Psychosocial Outcomes in Colorectal Cancer Patient-Spouse Dyads: A Randomized Controlled Trial
CONCLUSIONS: The BT program effectively improved both individual and dyadic outcomes, with patients benefiting immediately in psychological domains and caregivers exhibiting delayed improvements in relational outcomes during the follow-up period. These findings support implementing phased, role-sensitive dyadic interventions that address the distinct temporal needs of patients and caregivers in cancer care.
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Acceptability and efficacy of low-dose zinc with or without probiotics in acute watery diarrhoea-a prospective comparative study
Acute watery diarrhoea (AWD) has not been well-treated with 20 mg elemental zinc, primarily because of adverse symptoms like vomiting. In contrast to 20 mg of zinc, this study sought to determine whether a lower dose of zinc, with or without probiotics, is as beneficial as 20 mg of zinc, yet tolerated better. The aim…
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Learning to Unveil: Tackling Implicit Bias in Pain Recognition Through Education
CONCLUSIONS: This suggests that the intervention heightened students’ sensitivity to pain-related cues and encouraged a re-evaluation of clinical judgements. These results underscore the value of targeted educational initiatives in addressing disparities in pain recognition and treatment driven by facial cues, providing evidence that even brief interventions may contribute to mitigating implicit biases and support more…
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The stress reduction potential of Bhagavad Gita and Yoga for healthcare workers during the COVID-19 pandemic: A randomized controlled trial
BACKGROUND: Healthcare workers (HCWs) experienced elevated psychological distress during the COVID-19 pandemic. Culturally embedded, non-stigmatizing approaches may improve uptake of mental health support in this population. We aimed to evaluate the impact of Yoga, Bhagavad Gita learning, and their combination (Yoga+Gita) on psychological distress among HCWs.
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A secondary head-to-head comparison of low-intensity focused ultrasound and repetitive transcranial magnetic stimulation for motor recovery after stroke
CONCLUSION: LIFU and rTMS were associated with comparable short-term motor outcomes in subacute stroke. Differences observed in change-from-baseline motor improvements and exploratory neuroimaging measures suggest potential divergence in recovery dynamics and cortical modulation, warranting further investigation in larger, longitudinal studies.
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Positive Affect Treatment for Depression, Anxiety, and Low Positive Affect: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of 98 adults with severely low positive affect, depression, and anxiety, findings suggested that modulation of reward and threat processes was a central mechanism of therapeutic improvement, with a reward-focused intervention producing superior clinical outcomes.
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Brief Prolonged Exposure Therapy for Posttraumatic Stress After Spinal Cord Injury: A Randomized Controlled Trial
CONCLUSION: Brief PE was feasible, acceptable, and produced greater pain reduction than TAU. PTSD symptoms were also lower, though not significantly, suggesting promise for early psychological intervention after SCI.
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Motivation to Participate in a Nutrition and Physical Activity Intervention During Chemotherapy for Breast Cancer: A Qualitative Study
CONCLUSIONS: Women with breast cancer were motivated to participate in a nutrition and exercise intervention initiated during chemotherapy because of factors relating to optimizing their own health, altruistic desires, perceived lack of harm, and their oncologist’s recommendation. Compared to post-treatment, the opportunity to be proactive and having an oncologist recommendation emerged as unique motivators. Understanding…
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Visual Acuity Screening By by School Teachers in Far West Nepal: A randomized trial of alternate screening models
Background Studies have not examined alternate school visual acuity screening methods in Nepal in terms of accuracy and cost. Objective To validate recent evidence from India of the effectiveness and cost of alternate school visual acuity screening models involving all class teachers (ACTs) versus a few selected teachers (STs). Method This was a prospective cluster…
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Behaviorally Informed Text Messaging to Promote Colon Cancer Screening: A Quality Improvement Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this quality improvement randomized clinical trial, a behaviorally informed text messaging strategy was associated with significantly improved FIT completion compared with usual nurse-led telephone outreach. Automated messaging may offer a scalable, low-cost strategy to promote preventive care and reduce staff burden in underserved populations.