Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of prophylactic fibrinogen concentrate in scoliosis surgery (EFISS): a randomised pilot trial
CONCLUSIONS: This study demonstrates that the prophylactic administration of fibrinogen during scoliosis surgery in children is feasible and appears to be safe. Due to the limited sample size, no conclusions can be drawn regarding the efficacy of pre-emptive fibrinogen administration on clinical outcomes. However, the results provide valuable data to inform sample size calculation for…
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Cost analysis of integrating depression treatment into chronic care in Malawi: evidence from a cluster randomised controlled trial
CONCLUSIONS: These findings indicate that integrating depression care services into the Malawian health system is financially feasible and successfully reached many individuals with major depressive disorder.
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Dipsticks and point-of-care Microscopy in Urinary Tract Infections in primary care: Results of the MicUTI pilot cluster randomised controlled trial
CONCLUSION: The POCT-guided management approach for suspected uUTIs is feasible but presents implementation and methodological challenges. Recruitment varied across sites and was lower in the control group practices, highlighting the risk of differential recruitment. Retention was below the expected 80%, indicating the need for efficient follow-up strategies in future trials. Explorative analyses suggest that simply…
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Effect of a digital tool on breast cancer specific health-related quality of life and psychological distress: secondary results from the ADAPT study
CONCLUSION: The breast cancer digital tool did not have a significant effect on breast cancer-specific HRQoL and psychological distress over time. The results are consistent with the findings of the primary ADAPT paper, which demonstrated that the digital tool did not have a significant effect on patient activation, HRQoL, and health status. There is a…
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Efficacy of Stapled Haemorrhoidopexy vs. Ferguson Haemorrhoidectomy in the Treatment of Haemorrhoidal Disease: A Prospective, Randomised, Single-Blind Comparison
CONCLUSION: SH was equally effective as FH in controlling symptoms associated with HD in the postoperative period and may be recommended as a minimally invasive treatment option for patients.
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Can isokinetic muscle strength training with hip abduction and adduction improve muscle strength, balance, and gait in patients with functional ankle instability? A randomized controlled trial
CONCLUSIONS: Isokinetic strength training through the peri-ankle muscles combined with the hip adductor and abductor muscles was more effective than peri-ankle strength training alone in improving muscle strength, balance, plantar pressure, gait, and self-reported scores in FAI patients.
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Effect of caregiver training on knowledge and confidence of at-home clinical and anthropometric surveillance of children with uncomplicated severe acute malnutrition: analysis of a cross-over cluster randomised trial in Sokoto, Nigeria
INTRODUCTION: Patient-centred task-shifting models may be a promising strategy in the community-based management of severe acute malnutrition (SAM) to alleviate pressure on health systems and increase access to treatment in low-resource settings. The engagement of caregivers in clinical and anthropometric surveillance has not been evaluated.
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Are measures of voice hearing distinct from measures of emotional states, recovery and well-being? A factor analysis study
CONCLUSION: Findings show that measures of voice hearing are distinct from broad outcome measures and therefore are measuring separate concepts. This confirms the psychometric properties of the voice hearing measures and provides some clarity around outcomes and their measurement.
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The effects of intermittent escitalopram treatment on impulsivity and inattention in women with premenstrual irritability and anger
CONCLUSIONS: The finding that escitalopram impacted the outcome of the CPT 3 test in women with premenstrual irritability highlights the possible role of impulsivity in this condition.
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Ferula asafoetida oleo-gum resin alleviates dyspepsia symptoms through modulation of microbiome-gut-brain axis: A randomized, double-blind, placebo-controlled study
CONCLUSION: ASF demonstrated significant modulation of the microbiome-gut-brain axis, resulting in reduced dyspepsia symptom severity, enhanced cognitive performance, improved sleep quality, and better digestive outcomes. These findings support the potential of ASF as a safe and effective dietary supplement for gut and cognitive health in individuals with FD.