Clinical Trials
Category Added in a WPeMatico Campaign
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First-in-human (phase I) trial of SOL-116, a humanised IgG4 monoclonal antibody targeting bile salt-stimulated lipase, in healthy participants and rheumatoid arthritis patients
CONCLUSIONS: This study demonstrated that SOL-116 has a favourable safety and PK profile. Combined with effective reduction of free BSSL in the circulation, findings in this study support ongoing clinical development of SOL-116, with a focus on elucidating the efficacy and mechanism of action of BSSL in the treatment of chronic inflammation, primarily RA.
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Impact of Financial Incentives on Electronic Health Record-Driven Recruitment of Underrepresented Communities in Research: Randomized Controlled Trial
CONCLUSIONS: Patients with cancer who identify as part of a historically underrepresented group were less likely to view and respond to recruitment messages for research studies through their EHR patient portal. Age was also found to significantly impact engagement, with older patients less likely to view and respond. Finally, a modest US $20 financial incentive…
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Effect of Bone Cement Viscosity on Leakage and Outcomes in Vertebroplasty
Percutaneous vertebroplasty provides rapid pain relief in elderly patients with acute osteoporotic vertebral compression fractures; however, bone cement leakage remains a major safety concern, and the influence of cement viscosity on leakage and clinical outcomes is not fully established. This study evaluated whether high-viscosity cement reduces leakage without compromising efficacy or safety. In this single-center,…
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Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial
CONCLUSIONS: All evaluated therapies were effective in reducing DH over the 8-week follow-up period, with a progressive reduction in symptoms over time. However, no statistically significant differences were observed between the interventions, and no additive effect was identified for the combined therapy.
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A randomized crossover clinical trial of the Deseyne contact lens for presbyopia with extended depth of focus
CONCLUSIONS: The Deseyne contact lens for presbyopia with extended depth of focus extends the depth of focus of the eye and thus improves intermediate and near visual acuity.
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Intra- and inter-rater reproducibility of the echocardiographic data of the Nigerian UPRIGHT-HTM trial participants
CONCLUSION: The risk-carrying echocardiographic traits were obtained with moderate repeatability in three Nigerian tertiary referral centres. As data quality augments with expertise, these findings call for a Nigerian training programme in echocardiography with certification.
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Psychometric evaluation of the Mastocytosis Symptom Severity Daily Diary (MS2D2) in adults with nonadvanced systemic mastocytosis (NonAdvSM)
CONCLUSIONS: MS2D2 is a reliable, valid, and responsive instrument for assessing symptom severity in NonAdvSM, with evidence supporting its use in clinical trials to evaluate treatment benefit.
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Quantitative ultrasound evaluation of the thoracolumbar fascia after manual and acupuncture therapies: an exploratory mechanistic randomized controlled trial with a sequential within-subject phase
CONCLUSION: Chiropractic and massage, unlike acupuncture, elicited detectable biomechanical changes, while chiropractic also enhanced disability outcomes. HKD detected no microstructural changes.
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Video-Based Training on Physicians’ Proficiency in Invasive Fungal Disease: A Multicentre, Cluster Randomised Controlled Trial
CONCLUSION: Both video and PDF training modules are appealing to physicians. Further, the video training module displayed superior efficacy in improving physicians’ knowledge of IFD.
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Attachment Orientations and Treatment Outcomes in Psychotherapy: Does the Alliance Mediate the Association?
Previous research has demonstrated associations between patients’ attachment orientations and psychotherapy outcomes. Both theoretical and clinical literature suggest that the therapeutic alliance may serve as a mediator in this relationship. The present study investigated whether the therapeutic alliance mediates the connection between adult attachment and treatment outcomes in a clinical sample. One hundred eighteen patients…