Clinical Trials
Category Added in a WPeMatico Campaign
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Clinical Evaluation of a Thiamidol-Based Regimen With SPF Compared With SPF Alone for Facial Hyperpigmentation
CONCLUSION: These data support the integration of Thiamidol-containing formulations into existing skin regimens for individuals with facial hyperpigmentation.  .
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Evaluation of an Advanced, Multimodal Skin Tone Correcting Serum in Participants With Mild-to-Severe Dyschromia and Hyperpigmentation
CONCLUSIONS: A new multimodal skin tone correcting serum demonstrated significant improvements in MASI scores and in the appearance of skin texture and dullness. Significant improvements were also achieved in participants using both the skin tone correcting serum and double-conjugated retinoid/AHA cream. Participants reported high levels of satisfaction over 12 weeks.  .
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Efficacy and safety of a topical nitric oxide-releasing solution (NORS) as a noninvasive treatment for plantar warts (verrucae plantaris)
CONCLUSION: NORS demonstrated favorable safety and early clinical activity, warranting larger, longer-term efficacy trials.
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A Randomized, Controlled, Split-Face, Double-Blind Study Comparing Topical Malassezin to Hydroquinone 4% for Melasma
CONCLUSION: These findings suggest that malassezin shows comparable efficacy to the gold standard, hydroquinone. Our results further support malassezin as a promising new treatment for patients with melasma.  .
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Cluster-randomized evaluation of neonatal intensive care unit quality improvement interventions in extremely preterm infants: secondary analysis of the INTACT trial
CONCLUSIONS: This secondary analysis of a cluster-randomized controlled trial demonstrated that the intervention group receiving a NICU-specific QI program had reduced acute-phase morbidities, particularly among infants born between 22 and 27 weeks of gestation. Our findings highlight the potential for widespread clinical implementation of QI programs based on participatory learning and action in neonatal intensive…
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Clinical efficacy of 12 o’clock peripheral iridectomy in aphakic eyes undergoing pars plana vitrectomy with heavy silicone oil tamponade
Objective: To investigate the clinical effect of performing a 12 o’clock peripheral iridectomy during vitrectomy with heavy silicone oil tamponade in aphakic eyes. Methods: This was a prospective controlled study. Patients diagnosed with tractional retinal detachment secondary to proliferative diabetic retinopathy and scheduled to undergo combined lens extraction and pars plana vitrectomy with heavy silicone…
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Smartphone-Based Real-Time Assessment of Daytime Insomnia Symptoms With Suvorexant: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of older adults with insomnia, although traditional outcomes assessments detected no between-group differences, EMA was sensitive to detect effects of insomnia pharmacotherapy on daytime insomnia symptoms at various times of day, a critical gap in the literature.
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Cost-Effectiveness of Home-Based Self-Sampling vs Clinician Sampling for Anal Precancer Screening
CONCLUSIONS AND RELEVANCE: The findings of this economic analysis suggest that home-based anal cancer screening is a cost-effective approach to increasing screening participation among SGM individuals. Home-based screening may serve as a valuable and efficient tool for expanding screening rates.
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Repeatability and quality assessment of QFR in the FAVOR III Europe trial: the REPEAT-QFR study
CONCLUSIONS: In FAVOR III Europe, agreement between in-procedure and core laboratory QFR was modest. Measurement variability increased with reduced angiographic quality, poor in-procedure QFR analysis quality, and more advanced coronary artery disease.
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Effects of Remimazolam on Perioperative Inflammatory Response and Neurocognitive Disorders in Elderly Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial
CONCLUSION: Although remimazolam is less effective than propofol in suppressing the early postoperative inflammatory response in elderly patients undergoing VATS, it did not increase the risk of PND or infection. It has significant advantages in hemodynamic stability, facilitates faster recovery, and reduces injection pain, establishing it as a preferred anesthetic option for geriatric VATS, though…