Clinical Trials
Category Added in a WPeMatico Campaign
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Impact of nurse-led postoperative education on health outcomes following endovascular aortic repair: a randomized trial
The purpose of this randomized controlled clinical trial was to investigate the health effects of an education-based intervention performed at a nurse-led clinic, for patients who underwent endovascular treatment for abdominal aortic aneurysm. Fifty-four adult patients were randomized to the intervention group (n = 26) or the control group (n = 28). The control group…
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Home-based postural exercise as an adjunct to duloxetine improves sleep quality, physical quality of life, and trunk mobility in fibromyalgia: a randomized controlled trial
In fibromyalgia syndrome (FMS), current guidelines recommend combining pharmacological treatments such as duloxetine with exercise interventions. This randomized controlled trial aimed to evaluate the effectiveness of a home-based postural exercise program as an adjunct to pharmacological treatment in individuals with FMS. Fifty-one patients diagnosed with FMS according to the 2016 American College of Rheumatology criteria…
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Enhancing parental health knowledge through digital knowledge mobilisation tools: a randomised controlled trial and qualitative study
CONCLUSIONS: Blogshots can be an effective tool to disseminate child health information to parents. Due to the online dissemination, this approach could be scaled to a broader international level and applied to different health topics that are relevant across the world.
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Testability and test-retest reliability of SpotChecks Contrast Sensitivity Test in children with unilateral amblyopia
CONCLUSIONS: Children aged 6-12 years were more likely to be testable. Regardless of age, half of all test-retest pairs were completed incorrectly, possibly due to examiner or participant-related factors. A greater than 4-line (0.20 logCS) change on the SpotChecks contrast sensitivity test is required to detect a change in contrast sensitivity function beyond measurement error…
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Effectiveness of a Blended Intervention to Promote Physical Activity Among Office Employees: Randomized Controlled Trial
CONCLUSIONS: A blended intervention integrating tailored web content with interactive e-workshops significantly increased MVPA at T2 and T3 compared with both web-based and control groups. This success stems from the rigorous intervention mapping framework, which systematically identified effective behavior change and habit formation theories, while the blended approach addressed key limitations of traditional and web-based…
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Trust and Technology Acceptance: Comparing Traditional Search Engines and Artificial Intelligence for Colorectal Cancer Information Seeking
IntroductionThe integration of artificial intelligence (AI) into health information seeking is transforming health promotion. Understanding how users accept and trust these communication technologies is critical for health communication and cancer control. This study examined how the Technology Acceptance Model II (TAM II) applies to colorectal cancer information seeking, comparing link-based search (e.g., Google search) versus…
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A Controlled Trial on the Effect of Self-Compassion Group Psychotherapy on Adolescents With Major Depressive Disorder
Major depressive disorder (MDD) is a prevalent mental disorder among adolescents, yet its clinical management remains challenging. This controlled trial aimed to evaluate the effectiveness of self-compassion group psychotherapy as an adjunctive treatment for adolescents with MDD. Sixty adolescents with MDD were recruited from the First Affiliated Hospital of Chongqing Medical University between March and…
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Phase II randomised, placebo-controlled study to evaluate the efficacy and safety of an MK2 inhibitor in ankylosing spondylitis
CONCLUSIONS: Inhibition of MK2 by CC-99677 was insufficient to lead to significant clinical benefits in AS.
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Effect of Integrated Internet-Based Acceptance and Commitment Therapy and Behavioral Activation Among Ethnic Minority Young Adults With Alcohol Use Disorder in Hong Kong: Pilot Randomized Controlled Trial
CONCLUSIONS: This study, unlike existing evidence, presents an innovative integration of ACT and BA delivered via an internet-based self-help format. The findings contribute to the field by providing preliminary evidence that this integrated intervention is feasible and promising for AUD. The main implication in the real world is to conduct a fully powered randomized controlled…
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Echocardiographic Parameters for Predicting Atrial Fibrillation Following Ischemic Stroke: The PER DIEM Echocardiography Substudy
CONCLUSIONS: In patients with ischemic stroke, LAVI and LV GLS were significantly associated with subsequent AF detection. These findings may help risk stratify AF monitoring strategies for postischemic stroke management.