Clinical Trials
Category Added in a WPeMatico Campaign
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Safety and Efficacy of SOX Therapy After Preoperative Chemoradiotherapy for Advanced Lower Rectal Cancer: A Phase I Study
CONCLUSION: SOX therapy as consolidation chemotherapy after CRT was safe and well tolerated as part of the TNT for lower rectal cancer. To our knowledge, this is the first study to report the use of SOX in TNT. Further trials are warranted to evaluate the efficacy of SOX as consolidation therapy after CRT in larger…
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Pain sensitivity following a standardized two-hour cycling session: a randomized controlled crossover Study
CONCLUSION: Findings suggest that long duration exercise of a standardized moderate intensity may not be effective to induce EIH in trained male cyclists, while also no hyperalgesia is observed. These results are not different between loaded and unloaded body parts.
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Exploring Participant Perspectives on Implementation and Sustainment of Taking It to the Pews: A Faith-Based HIV Intervention With African American Churches
African American faith institutions can play a key role in increasing HIV education and testing in communities disproportionately burdened by HIV. This focus group study explored church participant perspectives of a religiously tailored HIV education and testing intervention implemented through a clustered, randomized controlled trial with 14 African American churches in Kansas City. Focus group…
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Clonal Dynamics of Hematopoiesis in Aplastic Anemia after Immunosuppression and Eltrombopag
CONCLUSIONS: CH was frequent in patients with AA and its prevalence appeared to be higher at posttherapy timepoints than at diagnosis. CH in AA may reflect the survival and expansion of selected residual hematopoietic stem/progenitor cells associated with immune-mediated damage. (Funded by Cancer Research UK, Bloodwise UK, and Novartis AG; ClinicalTrials.gov number, NCT02099747; EudraCT number,…
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The Effect of Probiotic Use on Gut Leakage Measured by Zonulin and its Relation to P Cresyl Sulfate and Inflammation in Hemodialysis Patients: A prospective controlled clinical study
CONCLUSIONS: Probiotic administration in hemodialysis patients improved intestinal barrier integrity, reduced gut-derived toxin levels, and lowered systemic inflammation.
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Effect of vitamin D supplementation on metabolic syndrome and atherosclerosis biomarkers in epilepsy: a randomized controlled trial
CONCLUSION: Vitamin D supplementation (2,000 IU/day) effectively restores 25(OH)D levels and improves adiponectin and hs-CRP in epilepsy patients on enzymatic ASMs, suggesting a potential benefit for cardiovascular risk reduction. However, vitamin D alone did not prevent the rise in homocysteine, likely due to the concurrent cessation of B-vitamin supplementation.
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Modified Cryotherapy During Final Irrigation Reduces Postoperative Pain and Anxiety in Pediatric Primary Molar Root Canal Therapy
CONCLUSION: Modified cryotherapy applied during final root canal irrigation significantly reduces short-term postoperative pain and enhances clinical cooperation in school-age children.
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Randomized Clinical Trial of Imagery Stabilization and Rescripting Therapy for Psychiatric Outpatients with Posttraumatic Stress Disorder
CONCLUSION: Our findings suggest that ISRT is a safe and effective treatment option for PTSD.
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Response of reticulocyte and red blood cell indices to single-dose intravenous iron in pregnant women with moderate iron deficiency anemia: secondary analysis of the RAPIDIRON trial
CONCLUSION: Intravenous iron therapy produces a more rapid and pronounced improvement in maternal red cell and reticulocyte indices than oral iron in moderately anemic pregnant women. Ret-He and IRF are emerging as early and sensitive biomarkers of iron availability and erythropoietic activity, with potential clinical utility for early detection of treatment response and optimization of…
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The effectiveness of care coordination on medication adherence among high-need, high-cost commercially insured beneficiaries: A randomized controlled trial
CONCLUSIONS: We found that care coordination did not improve medication adherence in HNHC beneficiaries. Our results align with prior studies and emphasize the challenges of improving adherence within a complex HNHC beneficiary population.