Clinical Trials
Category Added in a WPeMatico Campaign
-
Efficacy and safety of combined oral isotretinoin and desloratadine vs. isotretinoin alone in acne vulgaris: a comparative study
A combination of desloratadine (DESL) and oral isotretinoin (ISO) may enhance efficacy and reduce the side effects of ISO, particularly those affecting the skin and mucous membranes. We compared the efficacy and safety of this combination versus ISO alone with new dose regimens in the treatment of patients with acne vulgaris. This was a double-blinded,…
-
«There’s a lot of unknowns»: a thematic analysis of the experiences of young adults with cancer who died during a psychosocial intervention trial
CONCLUSIONS: YAs who approached end-of-life or saw unexpectedly fast declines in their healthcare trajectory showed many similarities to YAs outside of end-of-life contexts. Some, but not all, participants reflected on goals and challenges related to end-of-life during Bright IDEAs-YA participation. To ensure YAs are holistically understood, and that their priorities both prior to and during…
-
Usability and acceptability of ambulatory monitoring in undiagnosed syncope: insights from the ASPIRED-Q qualitative study
CONCLUSIONS: An immediate, enhanced (14-day) ambulatory ECG monitoring patch was positively received by patients and offered healthcare professionals an acceptable route for monitoring emergency department patients with unexplained syncope. However, future use should be controlled using standardised pathways to prevent inappropriate use.
-
Combined Treatment With Cognitive Behavioral Therapy for Insomnia and Acceptance and Commitment Therapy Enhances Objective and Subjective Reports of Sleep in Patients With Advanced Cancer
CONCLUSIONS: Multi-symptom interventions may be necessary for sustained insomnia improvements for people with advanced cancer. The FOCUS intervention is one of the first to demonstrate improvements on self-reported and actigraphic measures of sleep in addition to other symptoms (i.e., worry, uncertainty, depression, fatigue interference, distress) for this population. Future effectiveness studies are warranted given results…
-
Effectiveness and satisfaction of mindfulness-based cognitive therapy for children on anxiety, depression, and internet addiction in adolescents: Study protocol for a randomized control trial
Adolescents with Internet addiction (IA) frequently encounter elevated levels of anxiety and depression, which subsequently results in the perpetuation of their addiction behaviors. Mindfulness-based cognitive therapy for children (MBCT-C) is an adapted version of traditional MBCT that targets emotional problems in children. The present study aimed to provide a framework for the implementation of a…
-
Within-trial cost-effectiveness of novel macrophage-regulating treatment on wound healing in patients with diabetic foot ulcers
An M1/M2 macrophage-regulating treatment, ON101 cream, has shown its superior healing efficacy for diabetic foot ulcers (DFUs) versus standard absorbent dressing, according to a phase III trial. Given its high cost, corroborating the economic value of ON101 treatment can facilitate clinical and policy decision-makings. This study sought to evaluate the cost-effectiveness of ON101 versus an…
-
Efficacy and Skin Acceptability of a Cosmetic Cream for Nasolabial Dryness and Irritation
CONCLUSIONS: The results indicate that Sterimar soothing nose cream is effective in nourishing, soothing, protecting, and moisturizing the nasolabial zone, and is well tolerated.
-
A Comparison of Stockholm3, Serum Biomarkers, and Risk Calculators to Predict Prostate Cancer in a Racially and Ethnically Diverse Cohort: Evaluation of the Stockholm3 Multiethnic SEPTA Trial
CONCLUSIONS: Stockholm3 outperforms other commonly used biomarkers and risk calculators for detecting GG ≥ 2 cancer in a diverse population.
-
GymBuddy and Elomia, AI-integrated applications, effects on the mental health of the students with psychological disorders
CONCLUSIONS: Our findings suggest that AI-integrated interventions like GymBuddy and Elomia may serve as effective tools for reducing psychological distress in student populations. Integrating AI technology into mental health interventions offers personalized support and guidance, addressing a crucial need in student populations. Further research is warranted to explore long-term outcomes and optimize the implementation of…
-
Clinical Evaluation of the Effect of Aficamten on QT/QTc Interval in Healthy Participants
Aficamten is a next-in-class, small-molecule, cardiac myosin inhibitor in development for treating hypertrophic cardiomyopathy (HCM). This 2-part study evaluated aficamten’s impact on QTc interval in healthy participants. Part A (n = 10) was an open-label study to find the appropriate dose for thorough QT (TQT) evaluation in Part B. Part B (n = 34) was…