Clinical Trials
Category Added in a WPeMatico Campaign
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Does creatine cause hair loss? A 12-week randomized controlled trial
CONCLUSION: This study was the first to directly assess hair follicle health following creatine supplementation, providing strong evidence against the claim that creatine contributes to hair loss.
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Buccal Acupuncture Reduces the Dose of Sufentanil Needed in Laparoscopic Gynecological Surgery
BACKGROUND This study assessed the effects of buccal acupuncture on perioperative analgesia and serum inflammatory factors in patients undergoing laparoscopic gynecological surgery. MATERIAL AND METHODS Eighty patients who underwent elective laparoscopic gynecological surgery were selected and randomly allocated to the control and buccal acupuncture groups, with 40 patients in each group. Hemodynamic indices and dosages…
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Effects of Spirulina platensis supplementation on quality of life, severity of disease and serum total antioxidant capacity, malondialdehyde and zonulin in constipation-predominant irritable bowel syndrome: protocol for a randomised, double-blinded, placebo-controlled clinical trial from Iran
INTRODUCTION: Irritable bowel syndrome (IBS) is one of the most common chronic gut-brain interaction disorders. Nevertheless, there is currently no treatment for IBS. Low-grade inflammation and oxidative stress are contributing factors to the increased perception of abdominal pain and heightened sensitivity of the nervous system in these patients. Spirulina platensis is a rich source of…
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Effectiveness of immersive VR therapy in reducing stress-associated symptoms in Ukraine
Background: The ongoing conflict in Ukraine has led to a rise in stress-related symptoms, including anxiety and depression, among veterans, necessitating accessible and effective mental health interventions. Traditional rehabilitation resources are often limited, prompting exploration into alternative therapies.Objective: This paper aims to assess the effectiveness of immersive 360° video-based Virtual Reality (VR) therapy as an…
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Evaluation of the effectiveness of dextrose injection in improving chewing function in patients with the temporomandibular joint closed lock: a pilot study
CONCLUSION: D5W improved the chewing function in female closed-lock patients.
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Neoadjuvant sintilimab and chemotherapy for resectable esophageal squamous cell carcinoma: a phase II clinical trial
CONCLUSIONS: The combination of sintilimab and chemotherapy as a neoadjuvant regimen was tolerable and associated with favorable responses for ESCC patients. Given these favorable results, this regimen could serve as a viable alternative in the neoadjuvant treatment landscape for ESCC, with particular applicability to Chinese patient populations.
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Correlation between dexmedetomidine and postoperative sleep quality in older patients undergoing intestinal surgery
CONCLUSIONS: Dexmedetomidine enhances postoperative sleep quality in older patients undergoing intestinal surgery by reducing cortisol levels, increasing melatonin production and effectively alleviating pain, thereby supporting better recovery outcomes.
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Impact of a Heating Voucher on Health Outcomes in COPD Patients: A Randomised Controlled Trial
CONCLUSION: This study showed little effect of winter electricity vouchers on exacerbations of COPD. However, such vouchers increased energy use and may have reduced overall mortality. A larger study, particularly with susceptible subpopulations, is recommended to examine this mortality impact further.
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Nanovesicles for Sensitive Skin Care Developed via Self-Assembly of Glutamine Linoleate
CONCLUSIONS: QLAsomes showed up to 32% higher expression inhibition of key skin sensitization-related factors than individual components, and based on this, improved pruritus by 67% more than placebo. As nanovesicles with skin-soothing properties, they are effective for drug encapsulation and managing skin sensitivity in pharmaceutical and cosmetic industries.
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Association Between Plasma Amyloid-Beta 42 Ratio and Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery: Secondary Analysis of a Randomized Controlled Trial
CONCLUSIONS: This cohort study showed that a higher Aβ42 ratio was associated with an increased delirium risk and severity, and the association was linear. The plasma Aβ42 ratio might be a mini-invasive biomarker to identify postoperative delirium.