Clinical Trials
Category Added in a WPeMatico Campaign
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Efficacy of a Smartphone-Based Digital Therapeutic (Anzeilax) in Generalized Anxiety Disorder: Randomized Controlled Trial
CONCLUSIONS: Anzeilax demonstrated clinically meaningful efficacy in reducing anxiety symptoms when combined with TAU. The results showed consistent improvements across multiple anxiety measures, with effects sustained through follow-up. The incorporation of context-sensitive self-talk within an ACT-based DTx framework offers a promising and accessible solution for treating individuals with GAD.
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Physical Activity and BrainAGE: Exploring the Impact on Brain Health and Plasticity in Older Adults
With an aging global population, cognitive decline in older adults presents significant healthcare challenges. Emerging evidence suggests that physical activity can support cognitive health by promoting plasticity, functional reorganization, and structural adaptation of the brain. In the FIT4BRAIN study, we examined the effects of multi-component physical activity on cognitive and brain health. Here, we report…
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Assessment of QT Interval Prolongation Using Concentration-QT Modeling for Iptacopan, an Oral Complement Factor B Inhibitor, in Healthy Individuals
To assess cardiac and safety parameters of iptacopan (an oral, selective, reversible, small-molecule factor B inhibitor), we conducted a phase I, single ascending dose (SAD), exposure-response study (A2107) instead of a traditional thorough QT study. Healthy participants were randomized 3:1 to receive a single, supratherapeutic, oral dose of iptacopan 400, 800, or 1200 mg, or…
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Phase II study of dual epigenetic targeting with chidamide and azacitidine in patients with high-risk acute myeloid leukemia after allo-HSCT
CONCLUSIONS: Dual epigenetic targeting maintenance treatment with CHI-AZA has an acceptable toxicity profile and might potentially be effective to prevent relapse in high-risk AML patients after allo-HSCT.
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Development and external validation of a multivariate model for predicting pneumonia in patients receiving maintenance hemodialysis: a retrospective study
CONCLUSION: The created predictive model provided a precise, individualized evaluation of pneumonia risk in patients with MHD. It can be used to identify individuals at high risk of pulmonary infection in patients undergoing MHD and guide their treatment and prognosis follow-up.
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Unveiling the complexity: predicting long-term CPAP adherence among patients with moderate to severe OSA undergoing ‘Interval’ CPAP Titration study. A prospective randomised study
CONCLUSION: A trial of CPAP before a titration study could improve acceptability, lower the CPAP pressures and improve long-term adherence in patients with moderate to severe OSA.
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Effect of artificial intelligence-assisted personalized feedback on radiographic diagnostic performance of dental students: a controlled study
CONCLUSIONS: ChatGPT-4o based personalized feedback proved to be an effective tool for enhancing diagnostic performance and supporting learning in dental education. The findings suggest that AI-driven individualized educational strategies hold significant potential in the future of dental training.
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Comparative efficacy of 200 mg versus 1200 mg of simethicone with 3 L polyethylene glycol electrolyte solution for afternoon colonoscopy: a randomized controlled trial
CONCLUSION: 200 mg versus 1200 mg of SIM in 3 L PEG-ELS for afternoon colonoscopy demonstrated no statistically significant difference in bowel cleansing quality, ADR and bowel preparation-related adverse events. This evidence supports the clinical feasibility of 200 mg simethicone as an effective alternative for optimizing colonic preparation while maintaining procedural standards.
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Sputum colour charts to guide antibiotic self-treatment of acute exacerbation of chronic obstructive pulmonary disease: the Colour-COPD RCT
CONCLUSION: Under-recruitment precluded definitive conclusions. However, sputum colour is unlikely to be a useful addition to COPD SM in primary care.
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Smart Continence Care for People With Profound Intellectual and Multiple Disabilities Within Dutch Residential Care Facilities: Economic Evaluation Alongside a Cluster Randomized Trial
CONCLUSIONS: The results of this economic evaluation are not conclusive because of the mixed outcomes and a limited timeframe. SCC is ineffective in reducing the number of weekly leakages, but it does reduce the number of weekly IMCs. However, SCC was not effective in reducing time spent on continence care. Findings suggest that SCC is…