Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of a brief sexual-orientation-focused instructional intervention incorporating critical-thinking elements on immediate self-reported prejudice against lesbians and gay men: Baseline-adjusted evidence from a randomized experiment
CONCLUSIONS: Participants assigned to a brief sexual-orientation-focused instructional intervention that combined sexual-orientation information with two selected critical-thinking elements reported lower immediate self-reported PALG than participants assigned to a neutral-video control condition. The condition contrast did not isolate either selected element, and the outcome was measured immediately by self-report. The findings should therefore be treated as…
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Cost-effectiveness analysis of omeprazole for preventing esophageal stricture in patients with Zargar grade 2b and 3a corrosive esophageal injuries: A trial-based economic evaluation
CONCLUSION: Omeprazole plus standard treatment may represent a cost-effective strategy for adult patients with Zargar grade 2b and 3a corrosive esophageal injuries. However, these findings should be considered preliminary and require confirmation in larger multicenter randomized controlled trials.
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Webcam-Based Real-Time Visual Feedback During Baduanjin Practice in Older Adults: 6-Week Pilot Randomized Study
CONCLUSIONS: In this small exploratory pilot study conducted under supervised laboratory conditions, the 6-week trajectories did not differ significantly between groups. A marginally lower average 2D pose discrepancy was observed in the feedback group across the 6 weeks, but no individual week- or joint-specific comparison remained significant after multiplicity adjustment. Form 3 was the only…
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Measuring what matters: evaluating the psychometric properties of goal attainment scaling in a psychosocial dementia trial
CONCLUSION: GAS is feasible, valid and reliable, so may be a sensitive and clinically meaningful candidate primary outcome for psychosocial dementia trials. Correlations with global quality of life were significant but modest, consistent with GAS capturing personalised rather than generic outcomes.
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Five-year outcomes in a randomised controlled trial of prolonged exposure therapy and supportive counselling for post-traumatic stress disorder in adolescents: a task-shifted intervention
CONCLUSION: Adolescents with PTSD continued to maintain treatment gains up to 60-months post-treatment. These data, along with findings from the original RCT, indicate that a brief treatment protocol (averaging 9 sessions of PE-A or SC) in a LMIC, task-shifted to be delivered by nurses without prior psychotherapy experience, led to lasting improvements in PTSD and…
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Effect of sulodexide on the walking, erectile and cognitive functions based on the findings of the ANDANTE study
CONCLUSION: The ANDANTE study showed efficacy of sulodexide in patients with PAD. Taking sulodexide at a daily dose of 500-1000 LSU resulted in a statistically significant increase in the painless walking distance by 72.4%, improvement of self-reported walking ability by 71.0%, self-assessment of maintaining an erection by 14.8%, and cognitive function by 12.2%. These results…
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Course of arterial hypertension after open and endovascular procedures for significant carotid artery stenosis: single-center randomized study
CONCLUSION: Both carotid revascularization strategies significantly reduce SBP within the first postoperative year. In the long term, CEA with carotid body excision provides a more durable antihypertensive effect and a higher likelihood of achieving target BP compared with CAS. These findings suggest that the type of intervention may influence peripheral baro- and chemoreflex mechanisms of…
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Could creatine supplementation combined with physical rehabilitation accelerate return to play in athletes with patellar tendinopathy?
CONCLUSIONS: A physical rehabilitation program involving eccentric training, stretching, and ESWT is effective in reducing tendon thickness and increasing muscle strength. However. It seems that the addition of CR induces an earlier reduction of pain and a positive effect on CMJ performance. Therefore, CR could be considered as an ergogenic recovery aid in athletes with…
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Antibiotic-impregnated bone graft to prevent infection after total hip arthroplasty (ABOGRAFT): protocol for a randomised, double-blind, placebo-controlled trial
INTRODUCTION: Studies have shown promising results using bone graft as a carrier for local administration of antibiotics to reduce the risk of prosthetic joint infection (PJI). The objective of this clinical trial is to determine if tobramycin and vancomycin-impregnated bone graft is safe and effective in reducing the rate of PJI after total hip arthroplasty…
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Behaviourally informed text message reminders to increase cervical screening attendance in people with severe mental illness: the OPTIMISE pilot randomised controlled trial
CONCLUSIONS: Achieving adequate recruitment and retention, data completeness and comparable groups is viable with some amendments, although an alternative method is required to assess fidelity. Behaviourally informed SMS reminders are feasible to deliver to people with SMI, although it is uncertain if the extra resources are accessed and used. With changes to data collection, a…