Clinical Trials
Category Added in a WPeMatico Campaign
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Comparison of capsular stretching and passive joint mobilisation in idiopathic adhesive capsulitis of the shoulder: A randomised controlled trial
CONCLUSIONS: Both interventions significantly improved shoulder range of motion and reduced pain and disability. However, greater improvements were observed in shoulder flexion, extension, abduction, and SPADI scores in the control group, while internal rotation improved more in the experimental group, with similar gains in external rotation.
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Role of individualized intervention(s) on quality of life and adherence to adjuvant endocrine therapy in premenopausal women with early-stage breast cancer: MyCHOICE study
CONCLUSION: Individualized, patient-selected supportive interventions may help maintain key aspects of quality of life and support adherence to endocrine therapy in premenopausal women with early-stage breast cancer. These findings support further evaluation in larger, controlled trials.
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Transcranial direct current stimulation in affecting neuropsychiatric symptoms of post-COVID syndrome: No change in microstates and functional connectivity
CONCLUSIONS: We did not find a significant difference in selected EEG parameters between active and sham groups. The possible reasons include choice of tDCS parameters (electrode montage or stimulation duration), and EEG variables selected for evaluation (microstates and functional connectivity). These results are in line with the results of cognitive and clinical assessment. However, the…
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Efficacy and Safety of Lianhua Qingke Tablets in Children With Mycoplasma pneumoniae Pneumonia: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Clinical Trial
CONCLUSION: LHQK is a safe and effective adjunctive TCM therapy for mild MPP in children, offering significant benefits in respiratory symptom alleviation and a favorable safety profile, with a trend toward shorter recovery time, providing a valuable treatment option amid rising antibiotic resistance.
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Sensitive Skin Improvement Through Bioinformatics-Identified Cosmetic Ingredients That Regulate Transcriptome-Derived Biomarkers
Sensitive skin is characterized by hypersensitivity to normal stimuli, and objective diagnostic tools and treatments are still limited. Currently, cosmetics for sensitive skin are developed through the exclusion of known irritants rather than investigation into the underlying mechanisms of sensitivity. In this study, we developed an integrated pipeline combining transcriptome analysis via microneedle-based skin sampling…
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Evaluation of the Effect of Astragalus membranaceus Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort
CONCLUSIONS: 12 weeks of AMS supplementation was associated with improvements in selected functional, mobility, and outcomes in generally healthy adults with self-reported knee discomfort. AMS was also associated with changes in selected circulating biomarkers related to inflammation and cartilage metabolism. These findings should be interpreted as a preliminary, safe, complementary strategy to support joint health…
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Effects of Modest Carbohydrate-Energy Supplementation on Resistance Training Adaptations in Trained Men: A Crossover Trial
Background/Objectives: Higher energy and carbohydrate intakes have been hypothesized to enhance resistance training adaptations, yet empirical evidence remains mixed. The purpose of this study was to investigate whether supplemental carbohydrate-energy intake improves muscle hypertrophy and strength. Methods: Twenty resistance-trained men (26.7 ± 4.9 years old, 9.7 ± 6.1 years training experience) completed a quasi-randomized, double-blinded,…
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Geriatric team support in the emergency department-a randomised trial investigating the effects on hospital admission and community care in older adults (GerED-21)
CONCLUSIONS: By relieving pressure on inpatient services, the GT integration into ED workflows represents a scalable strategy for health systems facing demographic shifts and rising demand for age-sensitive care.
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An Internet-Based Mindfulness- and Compassion-Based Intercare Program for Reducing Parental Burnout: Randomized Controlled Trial
CONCLUSIONS: The culturally adapted, internet-based IBAP-BP program was feasible, safe, and effective compared with the waitlist condition for reducing parental burnout in working mothers, with effects sustained over 9 months, although it did not demonstrate superiority over the active control at the primary end point. Internet-based mindfulness- and compassion-based interventions may offer scalable, equitable options…
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Medical Record Abstraction for Quality Improvement in Sepsis Care Using Artificial Intelligence: A Cluster Randomized Trial
CONCLUSIONS AND RELEVANCE: In this cluster randomized trial of artificial intelligence (AI)-enabled medical record abstraction for sepsis care, rapid assessment of SEP-1 performance and targeted feedback improved overall compliance with the measure. AI-driven quality clinical integration may address limitations in existing hospital quality reporting and better support a learning health system.