Clinical Trials
Category Added in a WPeMatico Campaign
-
Does Attention-Deficit/Hyperactivity Disorder Predominant Presentation Matter? Examining Functional and Symptom Changes After Cognitive Behavioural Therapy
CONCLUSIONS: CBT is highly effective and durable across ADHD presentations and formats. Although the combined presentation exhibited a more pronounced reduction in core symptoms, this differential trajectory represents a promising clinical trend requiring cautious interpretation. While brief formats efficiently address core symptoms, standard programs may better optimize long-term functional recovery.
-
Who Should Decide the Outcome for a Clinical Trial? Comparing the Views of Stakeholders on Intervention Benefit Using Multi-Criteria Decision Modelling of Cognitive Remediation
CONCLUSIONS: This study shows how stakeholder values can identify nuances in outcomes depending on the value placed on treatment benefits. Embedding this approach into trial design can strengthen the alignment of outcomes with patient and service priorities and help close the gap between randomized trials and service implementation.
-
Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial
CONCLUSIONS: Triple therapy provided a better quality of life without compromising spermatogenesis. The AMH and Inh B provided an effective means of monitoring.
-
Optimal Switching Antiplatelet Regimen in Patients with Ticagrelor to a Thienopyridine in Korean Patients (SWAPT-K Study)
BackgroundDual antiplatelet therapy (DAPT) with aspirin and potent P2Y(12) inhibitors such as ticagrelor effectively reduces ischemic events but increases bleeding risk. In patients requiring long-term DAPT, switching from ticagrelor to a thienopyridine is often considered to reduce bleeding risk or address other clinical concerns. However, such switching may cause a transient reduction in platelet inhibition,…
-
Does aerobic exercise affect memory, attention, working memory, and fatigue after acquired brain injury? A single-blinded, randomized controlled pilot study
CONCLUSION: The question of whether aerobic exercise promotes cognition and fatigue after brain injury remains unanswered. This randomized controlled pilot study and its preliminary findings indicate greater improvements in executive processing speed in the aerobic exercise group, while more automatized attention speed improved more in the control group. The experiences from this study might facilitate…
-
Boosting oxytocin in postpartum depression
CONCLUSION: Oxytocin enhances positive maternal emotions in PPD and may represent a neurobiological link between PPD and reduced positive caregiving. Stimulating endogenous oxytocin release, such as skin-to-skin contact, could help strengthen the mother-infant relationship in PPD. Future research should clarify oxytocin’s therapeutic potential, taking into account administration context and PPD severity.
-
Comparison of the effectiveness of psycho-behavioral-relaxation and occlusal splint therapy in the treatment of myalgia
CONCLUSIONS: The reduction in myalgia following treatment suggests that both RPB exercises and ST are equally effective. However, considering the cost and duration of myalgia therapy, comprehensive care incorporating relaxation techniques may be a preferable first-line approach rather than ST alone.
-
Effect of Aquatic Training Versus Land Exercises on Motor Function in Children With Autism Spectrum Disorder: A Randomized Controlled Trial
CONCLUSION: AT demonstrated higher efficacy than LBE, yielding greater improvements in motor development and QoL, as well as more pronounced enhancements in sensory integration among young children with ASD. Thereupon, it is worthwhile for physical rehabilitation practitioners to include the AT in the intervention plans for children with ASD.
-
The Efficacy of Treadmill Walking Program on Gait and Body Mass Index of Children With Autism Spectrum Disorder: Randomized Controlled Study
CONCLUSION: Treadmill training may be effective in reducing percentile BMI and lower limb mobility in children with ASD. These findings support its use for combined weight management and motor improvement. But the findings indicated the need for future research with larger samples and longer follow-up to clarify its clinical significance.
-
Clinical dose-effect study of acupuncture at Lianquan (CV23) with different frequencies of twirling manipulation for post-ischemic stroke aphasia
CONCLUSION: Compared with the high-frequency twirling manipulation acupuncture at Lianquan (CV23), the low-frequency twirling manipulation acupuncture has a better effect in improving the language function, neurological function and quality of life in patients with post-ischemic stroke aphasia.