Clinical Trials
Category Added in a WPeMatico Campaign
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Open-Label, Prospective Study of a Prebiotic Gel Cream on Its Efficacy of Mild to Moderate Acne Management and Effects on the Functional Skin Microbiome
CONCLUSIONS: This prebiotic-containing gel cream can be an effective form of management for acne vulgaris by creating beneficial shifts in the skin microbiome.
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Evaluating the impact of easy-to-understand patient letters after discharge on patients’ health literacy: a randomized controlled study
CONCLUSIONS: Patient letters were associated with higher post-intervention health literacy in cardiologic patients and were well received. These results suggest that broad implementation of patient letters may benefit both patients and healthcare providers by enhancing patients’ understanding of medical information regarding diagnoses and treatment, potentially contributing to improved health-related outcomes.
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Intravascular Imaging vs Angiography Guidance for PCI of Severely Calcified Lesions: The ECLIPSE Trial
CONCLUSIONS: IVI guidance during PCI of severely calcified lesions was associated with improved 1-year clinical outcomes compared with angiographic guidance alone, whether OA or BA was used for vessel preparation prior to drug-eluting stent placement. The adjusted difference in 1-year TVF rates were not significantly different with optical coherence tomographic guidance and IVUS guidance.
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A randomized prospective clinical study evaluating the effectiveness of the Beautibond Xtreme adhesive system using different bonding techniques in class I and II restorations: one-year results
CONCLUSION: The Beautibond Xtreme adhesive system demonstrated better clinical performance when applied with total-etch or selective enamel etching techniques compared to the self-etch mode for both Class I and Class II restorations after one year of follow-up.
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Early substrate-based catheter ablation vs. antiarrhythmic drug therapy for ventricular tachyarrhythmias among patients with prior myocardial infarction: the MANTRA-VT randomized trial
CONCLUSION: Early substrate-based RFCA was associated with reduced risk of ICD therapies, but with no meaningful difference in VT/VF burden, mortality, hospitalization, and adverse events.
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Long-acting intranasal insulin for the treatment of delirium-a randomised clinical trial
CONCLUSION AND RELEVANCE: This is the first study of intranasal insulin for delirium treatment. The reduced LOS combined with the observed age-related effects warrants further investigation into the clinical potential of intranasal insulin in managing delirium in older patients.
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The development, acceptability and preliminary efficacy of a sleep health intervention on frailty and quality of life in older adults
CONCLUSION: A sleep health intervention was favourable and effective in older adults and improved quality of life.
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The influence of photodynamic therapy on the supragingival plaque accumulation and bacterial composition in orthodontic patients: a randomized controlled trial
CONCLUSION: The effects of PDT on oral health were mostly comparable to those produced by CHX and TCP-5% NaF varnish and significantly different from those observed in the control group.
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Evaluating the efficacy of opioid-sparing analgesic protocols in postoperative pain management for major trauma surgeries
This randomized, controlled trial evaluated the efficacy of opioid-sparing analgesic protocols in postoperative pain management for major trauma surgeries. A total of 120 patients were randomly assigned to either an opioid-sparing group or a conventional opioid-based group (n = 60 per group). Primary outcomes included pain severity, opioid use, and postoperative mobilization. The opioid-sparing group…
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Effects of a psychoeducational group intervention for adults diagnosed with ADHD: a pilot randomized controlled study
CONCLUSION: This psychoeducational group intervention significantly improved QoL and patient satisfaction but not symptom burden in adult patients with ADHD. Future studies should explore the long-term effects of psychoeducational group programs and examine ways to optimize treatment outcomes.