Clinical Trials
Category Added in a WPeMatico Campaign
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Participants’ Perspectives on Health Impact, Barriers and Facilitators to Adherence in a Mediterranean Diet Lifestyle Trial
Background/Objectives: Interventions promoting the Mediterranean Diet (MedDiet) and healthy lifestyle behaviours are effective and cost-efficient in preventing non-communicable diseases (NCDs), yet sustaining adherence remains challenging. This study explored perceived health impacts on, barriers to, and facilitators of adherence among older Spanish adults participating in a randomised clinical trial (RCT) based on the MedDiet and lifestyle…
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School-based behaviour change intervention to reduce ultra-processed food consumption among adolescents: evidence from a cluster-randomised controlled trial in India
CONCLUSION: This study demonstrates the potential of school-based behavioural interventions to reduce UPF consumption among Indian adolescents, addressing a critical gap in public health research and practice in LMICs.
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Postoperative pain and quality of life after the use of different endodontic sealers in asymptomatic molars: a randomized clinical trial
CONCLUSIONS: Overall, both sealers resulted in very low postoperative pain. Although AH Plus showed slightly higher pain intensity compared with BC, both sealers demonstrated a similar risk of pain and comparable impact on quality of life.
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Prospective Audit and Feedback by Antibiotic Stewardship Teams to Reduce Antibiotic Overuse at Hospital Discharge: A Stepped-Wedge Cluster-Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this stepped-wedged cluster-randomized clinical trial conducted across 10 hospitals, discharge-focused prospective audit and feedback did not decrease antibiotic use at hospital discharge but did improve optimal antibiotic prescribing for common and uncomplicated diagnoses. Other AS strategies are needed to decrease unnecessary antibiotic prescribing at this transition of care.
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Opportunistic Genomic Screening for Familial Hypercholesterolemia to Improve Low-Density Lipoprotein Cholesterol: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this RCT, opportunistic genomic screening for FH plus telegenetic counseling did not result in a statistically significant improvement in LDL-C levels and clinical management; however, the findings suggest that there may be a small to moderate benefit favoring the immediate results arm. Further research should be conducted to confirm these findings,…
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Safety of a cytomegalovirus-specific hyperimmunoglobulin in the prevention of maternal-fetal transmission after primary infection-results of an open-label, single-arm, prospective trial
CONCLUSION: Despite a favorable safety profile, the benefit of treatment with CMVIG to prevent a maternal-fetal CMV transmission could not be demonstrated in our trial.
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The effect of sleep hygiene education on sleep quality and blood pressure in patients with essential hypertension in a family practice center: a randomized controlled trial
CONCLUSIONS: Sleep hygiene education delivered in a primary care setting significantly improved sleep quality and reduced blood pressure levels in patients with essential hypertension. This approach may also help prevent complications related to hypertension. Clinical trial registration: ClinicalTrials.gov (Identifier: NCT07257237; registered on 20 November 2025).
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Dexketoprofen Time-Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross-Over Controlled Trial
CONCLUSIONS: Daytime administration of NSAIDs might be sufficient to manage postoperative pain after third molar extraction, and complications were similar between both groups.
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Long-term effects of mentalization-based treatment for psychotic disorder: a 5-year follow-up of a multi-center, randomized-controlled trial
CONCLUSION: The results suggest a durable effect of MBTp.
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Impact of Family-Centred Care Combined With Psychological Intervention on Sleep Quality and Psychological Status in Children With Bronchopneumonia: A Controlled Trial
CONCLUSION: FCC combined with psychological intervention effectively enhances sleep quality, mitigates anxiety, promotes treatment adherence and improves family satisfaction among children with bronchopneumonia. This provides practical evidence for the application of this comprehensive nursing model in paediatric clinical practice and research in the field of family-centred comprehensive interventions.