Clinical Trials
Category Added in a WPeMatico Campaign
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Efficacy and Safety of Clascoterone Cream 1% for Acne Are Independent of Age and Sex
Acne vulgaris is an inflammatory skin condition affecting adolescents and adults of both sexes. Clascoterone cream 1% is indicated for the topical treatment of acne vulgaris in patients ≥12 years of age based on the results of two Phase 3 trials (NCT02608450 and NCT02608476). This post hoc analysis evaluated the efficacy and safety of clascoterone…
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The effects of a mobile application-based dementia care intelligent recommender system on caregivers of people with dementia: a randomized controlled trial
CONCLUSION: In summary, this RCT showed that the DCIRS may reduce caregivers’ distress related to care problems and lessen caregiver burden. Although depressive symptoms did not improve significantly, further research is needed to assess long-term effects and clarify the mechanisms underlying remote, personalized interventions such as the DCIRS.
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Functional capacity and quality of life after telerehabilitation in post-tuberculosis lung disease: a randomized controlled trial
CONCLUSIONS: Our findings suggest that telerehabilitation is an effective approach for enhancing physical function and QoL in patients with PTLD.
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Probiotic Supplementation Reduces RRTIs and Enhances Gut Microbial and Immunity in Children: A Randomized Controlled Trial
Recurrent respiratory tract infections (RRTIs) are a major cause of morbidity in children, and strain-defined probiotics have been proposed as a supportive preventive strategy, although clinical evidence remains limited. In this randomized, double-blind, placebo-controlled trial, 120 children diagnosed with RRTIs received either Bifidobacterium animalis subsp. lactis XLTG11 and Lactiplantibacillus plantarum CCFM8661 or a matched placebo…
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The Safety and Efficacy of Absnow Fully Biodegradable Atrial Septal Defect Occluder: A Prospective, Single-Center Phase III Clinical Trial
CONCLUSION: This study further confirmed the short-to-mid-term safety and acceptable efficacy of the Absnow fully biodegradable atrial septal occluder based on a 4-year follow-up. The late-occurring residual shunts with device degradation have an important impact on its long-term efficacy.
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Safety and tolerability of avacincaptad pegol in combination with ranibizumab in treatment-naïve patients with neovascular age-related macular degeneration: results from a phase 1 and phase 2a study
CONCLUSIONS: Coadministration of ACP and ranibizumab in treatment-naïve patients with nAMD was well tolerated across different dosing regimens with no new safety issues based on results from two independent studies.
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Effect of Bioptron light therapy on dryness of eyes in postmenopausal women: a randomized controlled trial
To examine the short-term therapeutic effects of Bioptron light therapy (BLT) on dry eye disease (DED) in postmenopausal women. Sixty postmenopausal women diagnosed with DED, aged 50-62 years with a body mass index ≤ 30 kg/m², were randomly assigned to two equal groups. The Bioptron group (n = 30) received BLT for 10 min, twice…
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Treatment of peri-implant mucositis using an erythritol air-polishing or ultrasonic device: A randomized controlled trial
CONCLUSION: Both EAP and US effectively treated peri-implant mucositis with comparable overall efficacy. However, EAP showed superior potential in reducing deep pockets over the short term, though this finding required further validation.
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Niacin Modulates Immune Responses in a Phase I Dose-Escalation Clinical Trial of Newly Diagnosed Glioblastoma
BACKGROUND AND OBJECTIVES: Glioblastoma, a highly aggressive and uniformly lethal brain tumor, resists current treatments and immunotherapies by creating a potently immunosuppressive microenvironment. The objective of this study was to determine whether niacin modulates systemic immunity in patients with newly diagnosed glioblastoma.
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Selective Personality-Targeted Intervention and the Escalation of Substance Use During Adolescence: A Secondary Analysis of A Cluster-Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This secondary analysis of a cluster-randomized clinical trial found that personality-targeted interventions protected against the escalation in substance use during adolescence, with similar effects for males and females.