Clinical Trials
Category Added in a WPeMatico Campaign
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Persistent Vomiting Among Children With Acute Gastroenteritis: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this analysis of children presenting for ED care with vomiting, younger children and those unwell for 24 to 48 hours with 10 or more episodes of vomiting at presentation were more likely to have persistent vomiting after discharge. Based on these findings, these children are most likely to benefit from being…
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Efficacy of a Modular Lifestyle Intervention Through Occupation for Individuals With Rheumatoid Arthritis: A Randomized Controlled Trial With 6-Month Follow-Up
CONCLUSIONS AND RELEVANCE: The LI produced durable improvements in occupational performance and patient-reported outcomes, supporting its integration as a sustainable adjunct to pharmacological care for individuals with RA. Plain-Language Summary: People with rheumatoid arthritis often have difficulty completing daily activities because of pain, fatigue, and limitations in movement. This study explored whether a structured lifestyle…
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Efficacy and Safety of Non-Cross-Linked Hyaluronic Acid Mesotherapy for Post-Acne Erythema: A Split-Face, Prospective, Randomized, Single-Center Trial
CONCLUSION: According to the results of this study, non-cross-linked HA mesotherapy is a promising and useful therapeutic option for PAE.
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Clinical controlled study of Zhongyi Ointment() in the treatment of Kellgren-Lawrence grade knee osteoarthritis with moderate-to-severe pain
CONCLUSION: Zhongyi Ointment() can rapidly and significantly improve symptoms in patients with K-L gradeⅡknee osteoarthritis with moderate-to-severe pain during the acute exacerbation stage, with definite short-term efficacy and favorable safety. Continuous treatment helps to consolidate the therapeutic effect and warrants further validation through multicenter studies with large sample sizes, as well as investigations into the…
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Nutrition-sensitive agriculture programme impacts women’s mental health via food security in rural Bangladesh
CONCLUSIONS: On average, intervention participants had better mental health 1 year after the programme ended, with some of the effect mediated by increased food security. There are likely other pathways through which nutrition-sensitive agriculture can improve mental health, such as social protection and income, which may act synergistically.
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Effects of a Web-Based Intercultural Midwifery Training Program on Cultural Sensitivity and Intercultural Effectiveness Among Midwifery Students: A Multicenter Randomized Controlled Trial
CONCLUSION: A web-based intercultural midwifery training program seems to be an effective approach for increasing the cultural sensitivity and intercultural effectiveness of midwifery students.
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Effects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial
CONCLUSION: Acute post-exercise HMB-FA supplementation in elite judo athletes did not significantly influence muscle damage or oxidative stress markers but transiently increased antioxidant enzyme activities (CAT, GPX, and SOD). These findings suggest an enzyme-specific effect and highlight the need for future studies using more precise oxidative-stress markers and cellular assays to better evaluate antioxidant responses;…
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Theoretical Cost-Effectiveness of PCSK9 Inhibitors in Stroke Due to Intracranial Atherosclerosis
CONCLUSIONS AND RELEVANCE: This theoretical framework suggests that alirocumab and evolocumab were cost-effective for preventing recurrent stroke in patients with severe intracranial atherosclerosis, with all agents cost-effective under current cost-sharing programs offered by commercial and Medicare plans.
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Effects of incentive spirometer added to standard rehabilitation in previously hospitalized adults with post-COVID-19 condition: a randomized controlled trial
CONCLUSION: Adding incentive spirometry to standard rehabilitation improved peak expiratory flow and reduced dyspnoea in adults with post-COVID-19 condition, supporting its use as a low-cost adjunct for respiratory symptom management.
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Serum Biomarkers and CT-Derived Muscle Indices in Sarcopenia Associated with Pancreatic Neoplasm: A Comparative Clinical Study
Background: Sarcopenia is a frequent and clinically relevant condition in patients with pancreatic neoplasm, contributing to poor prognosis, reduced therapeutic tolerance, and increased mortality. The identification of reliable circulating biomarkers, alongside imaging-based muscle assessment, may improve early detection and risk stratification. Methods: This randomized prospective study included 61 patients, of whom 36 had pancreatic neoplasm…