Clinical Trials
Category Added in a WPeMatico Campaign
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Safety and efficacy of biosimilar aflibercept MYL-1701P in diabetic macular oedema: 20-week extension results following the INSIGHT pivotal trial
CONCLUSION: The study had certain limitations, including participation from one geographical area, an open-label design and small number of participants. Despite the limited number of exposures in the switch arm, it still constituted a reasonable exposure, and similar safety, efficacy and immunogenicity profiles were observed between those who continued receiving MYL-1701P and those who switched…
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Targeting homologous recombination deficiency with intensified chemotherapy versus standard chemotherapy followed by olaparib in stage III breast cancer (SUBITO): an open-label, randomised, controlled, phase 3 trial
BACKGROUND: Patients with stage III, human epidermal-growth-factor-receptor 2 (HER2; also known as ERBB2)-negative breast cancer with homologous recombination deficiency (HRD) had a 4-year overall survival of 35% after anthracycline-based chemotherapy versus 78% after intensified alkylating chemotherapy with autologous stem cell rescue (IACT) in a post-hoc analysis of an earlier randomised controlled trial. In this study,…
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SBRT plus abiraterone acetate and ADT versus abiraterone acetate and ADT in oligometastatic castrate-resistant prostate cancer (ARTO): long-term, unplanned overall survival analysis of an open-label, randomised, phase 2 trial
BACKGROUND: The ARTO trial showed improved early clinical outcomes by adding metastasis-directed therapy (MDT), through stereotactic body radiotherapy (SBRT), to abiraterone acetate and ADT in oligometastatic castrate-resistant prostate cancer. The aim of this analysis is to explore the long-term impact of MDT on overall survival.
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Relationship between the consistency of auxiliary provocation tests with the supine roll test and treatment outcomes for horizontal semicircular canal benign paroxysmal positional vertigo
Objective: To explore the consistency of lateralization of the head-shaking test (HST), lying-down test (LDT), and rapid axial roll test (RART) with the supine roll test (SRT), and to investigate their relationship with repositioning efficacy in patients with horizontal semicircular canal benign paroxysmal positional vertigo (HC-BPPV). Methods: Patients diagnosed with primary HC-BPPV using SRT and…
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The Effect of Konjac Glucomannan on Blood Glucose and Insulin Levels in Obese Patients With Prediabetes
CONCLUSION: KGM can effectively control fasting blood sugar and promotes weight loss, lowers blood sugar, and enhances insulin sensitivity in obese individuals with prediabetes.
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Efficacy of an exercise oncology program on sleep quality and circadian rhythm in head and neck cancer patients undergoing chemo-radiation therapy: a randomized controlled trial
CONCLUSION: An exercise oncology program has potential benefits in improving quality of sleep and regulating the circadian rhythm in HNC patients undergoing chemo-radiation therapy.
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Heat-sensitive Moxibustion Enhances Immunity in Advanced Non-small Cell Lung Cancer via Th1/Th2 and Treg/Th17 Regulation
CONCLUSION: HSM may enhance immune function in patients with advanced NSCLC undergoing chemotherapy by modulating the balance of Th1/Th2 and Treg/Th17 cell subsets.
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Efficacy and safety of the Chinese herbal medicine Xiao’er Niuhuang antipyretic plaster for treating fever in children with acute upper respiratory tract infection with wind-heat syndrome: a multicenter, randomized, double-blind, controlled clinical trial
CONCLUSION: Xiao’er Niuhuang antipyretic plaster is an effective and safe treatment for fever in children with AURI and wind-heat syndrome.
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Effects of Short-Term Versus Long-Term Mentalization-Based Therapy on Psychiatric Symptoms in Outpatients With Borderline Personality Disorder: Exploratory Results From a Randomized Clinical Trial
We conducted a randomized clinical trial assessing the beneficial and harmful effects of short-term versus long-term mentalization-based therapy (MBT) for outpatients with borderline personality disorder (BPD) and found no evidence of a difference on BPD symptom severity, functional impairment, quality of life, global functioning, and severe self-harm. In this paper, we assessed the effects of…
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Effects of Ayres sensory integration therapy versus conservative treatment in autism spectrum disorder
The study was conducted to evaluate the effects of Ayres sensory integration therapy versus conservative treatment in autism spectrum disorder. In a prospective randomised controlled trial, we assessed pre- and post-intervention scores of both the intervention group (A) that took ASI and the control group (B) that received conservative treatment-only behaviour therapy, speech therapy, and…