Clinical Trials
Category Added in a WPeMatico Campaign
-
Development and internal validation of a clinical prediction model for septic shock in pediatric respiratory syncytial virus bronchiolitis based on routine blood biomarkers and concomitant fungal infection
CONCLUSIONS: We developed and internally validated a prediction model incorporating fungal co-infection, admission glucose, antithrombin III, and interleukin-6 for early identification of septic shock risk in pediatric RSV bronchiolitis patients. The model demonstrated good discrimination (AUC 0.892) in this single-center cohort. However, given the modest sample size, external validation in larger, multicenter populations is essential…
-
Early choroidal thickness changes predict myopia control response to peripheral defocus spectacles in premyopic children
CONCLUSIONS: Peripheral defocus spectacles significantly controlled axial elongation and reduced myopia incidence in premyopic children with insufficient hyperopic reserve. Three-month choroidal thickness changes represent a valid early predictive biomarker for treatment response, enabling personalized intervention by 3 months rather than waiting 12 months for conventional outcomes. Early choroidal thickening identifies optimal responders, supporting choroidal perfusion…
-
Prehospital Use of Non-Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial
CONCLUSION: The clinical effect of prehospital non-invasive ventilation could not be determined due to early termination. This trial highlights important challenges relevant to future clinical trials in the prehospital setting, including patient selection, diagnostic requirements and implementation of complex interventions.
-
12-weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin-1 and inflammatory markers in men with obesity: a randomized controlled trial
CONCLUSION: Twelve weeks of concurrent interval resistance-aerobic training, especially when combined with fisetin, improved inflammatory resolution (↑Maresin‑1, ↓IL‑6, and ↓TNF‑α) and metabolic control (↓FBS, ↓insulin, and ↓HOMA‑IR) in obese men. The synergy between exercise‑induced adaptations and fisetin’s anti‑inflammatory properties offers a promising non‑pharmacological strategy for mitigating obesity‑related metabolic risk.
-
Expressive writing intervention on optimism and coping modes of newly diagnosed people with human immunodeficiency virus: A randomized controlled trial
CONCLUSION: The expressive writing intervention would improve optimism and promote more positive coping modes for newly diagnosed people with HIV.
-
A Personalised and Gamified Digital Decision Aid for Colorectal Cancer Screening: A Randomised Controlled Pilot Study
CONCLUSIONS: Preliminary findings suggest that a digital DA with personalised and gamified content may enhance CRC screening uptake and partially support informed choice. Larger, multisite studies are warranted to evaluate scalability, inclusivity, and long-term effectiveness in population-based cancer prevention.
-
Exploring transdiagnostic factors for mental health screening in primary care: a secondary analysis of a randomised controlled pilot study
OBJECTIVE: This secondary analysis of a randomised controlled pilot study (n = 87 patients) examined how transdiagnostic factors-including emotion regulation mechanisms (emotion beliefs, cognitive reappraisal, emotion suppression and experiential avoidance) and negative affectivity-relate to depressive, anxiety and somatic symptoms in the primary care setting, and whether emotion regulation mechanisms provide potential screening relevance beyond negative…
-
Lorazepam Versus Diazepam in Alcohol Dependence Syndrome: Which Is Better?
Objective: To compare the efficacy of lorazepam and diazepam in managing alcohol withdrawal and associated anxiety and depressive symptoms in alcohol dependence syndrome.
-
A Randomized Trial to Investigate the Effects of Low-Dose Colchicine in Patients with Hypertension: Rationale and Design of the COlchicine and HypERtENsion Trial (COHERENT)
Hypertension is a prevalent and significant risk factor for cardiovascular disease (CVD). The immune system and inflammatory response are involved in the pathophysiology of hypertension. We hypothesize that treating hypertension with colchicine on top of standard therapy, will decrease pulse wave velocity (PWV), left ventricular mass, cardiac/inflammatory biomarkers. COHERENT was an investigator-initiated, single-center, prospective, randomized,…
-
Modifying implementation strategies for integration of screening and management of mental disorders, including substance use disorders into other NCD care in Faridabad, Haryana as part of ICMR-MINDS project
CONCLUSION: The study highlights the importance of systematic approach and documentation for adapting implementation strategies to real-world conditions. The modified strategies intend to offer a feasible approach to integrated MSUD care in Faridabad district of Haryana. The findings indicate feasibility and system fit. Further evaluation is required to assess effectiveness and scalability.